1. Budget impact analysis of warfarin reversal therapies among hip fracture patients in Finland.
- Author
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Purmonen T, Törmälehto S, Säävuori N, and Kokki H
- Subjects
- Aged, Blood Coagulation Factors administration & dosage, Blood Coagulation Factors economics, Budgets, Female, Finland, Humans, International Normalized Ratio, Male, Plasma, Time Factors, Vitamin K administration & dosage, Vitamin K economics, Warfarin adverse effects, Anticoagulants adverse effects, Health Care Costs, Hip Fractures surgery, Warfarin antagonists & inhibitors
- Abstract
Background: Hip fractures require operation within 36-48 h, and they are most common in the elderly. A high International Normalized Ratio should be corrected before surgery. In the current study, we analyzed the budget impact of various warfarin reversal approaches., Methods: Four reversal strategies were chosen for the budget impact analysis: the temporary withholding of warfarin, administration of vitamin K, fresh frozen plasma (FFP), and a four-factor prothrombin complex concentrate (PCC)., Results: We estimated that, annually, 410 hip fracture patients potentially require warfarin reversal in Finland. The least costly treatment was vitamin K, which accounted for €289,000 in direct healthcare costs, and the most costly treatment option was warfarin cessation, which accounted for €1,157,000. In the budget impact analysis, vitamin K, PCC and FFP would be cost-saving to healthcare compared with the current treatment mix., Conclusion: The various warfarin reversal strategies have different onset times, which may substantially impact the subsequent healthcare costs.
- Published
- 2015
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