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Four scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12-epi-19-O-methylscalarin (3) and methyl 18-hydroxy-19-norscalar-16-en-20-carboxylate (4) were isolated from the Bornean spongeSpongiasp. The distinction between 12 a -OAc and 12 b -OAc, and 19-olide and 20-olide in sesterterpenes were revealed as well as previously not assigned relative configuration at 18-OH of4is reported herein for the first time. In addition, compounds1-3showed strong cytotoxic activities against adult T-cell leukemia (ATL), S1T cells. This is the first record of scalarane sesterterpenes from the Bornean sponge.