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Trityl-type new protecting groups were easily prepared from the reaction of 1-bromonaphthalene or 2-bromonaphthalene and 4-methoxy substituted benzophenones following the Grignard reaction. Aryl-methyl alcohols were transferred to tetrafluoroborate salts using tetrafluoroboric acid. The alcohols also reacted with acetyl chloride to give halides of the protecting groups. The selective protection of amine, sulfur, and hydroxyl groups was obtained by the reaction of the newly synthesized protecting groups (halides and tetrafluoroborate salts). Slightly aqueous acidic conditions were used for deprotection reactions to give alcohols. It can be said that the new protective groups synthesized in this study can be a good alternative to other protecting groups in terms of low solvent use, simple procedures, economic advantages, and environmental protection. [ABSTRACT FROM AUTHOR]

The 1,1'-(5,5'-(1,3-phenylene)bis(3-aryl-4,5-dihydro-1H-pyrazole-5,1-diyl))di-ethanone (5a-e) and 1,3-bis(1-phenyl-3-(aryl)-4,5-dihydro-1H-pyrazol-5-yl)benzene (6a-e) were synthesized by addition of hydrazine hydrate and/or phenylhydrazine to 1,3-phenylene-bis-chalcone derivatives (3a-e), respectively. The structures of obtained compounds (5a-e and 6a-e) were characterized using the spectroscopic methods (NMR, IR) and elemental analysis. Addition, the in vitro antibacterial activities of compounds (5a-e) was tested against the five human pathogenic bacteria. Gentamycin and Fluconazole were used as positive control. The results were given as inhibition zone (mm) and the compounds 5d and 5e showed the same activity with standard (Fluconazole) against C. albinas. [ABSTRACT FROM AUTHOR]

2-Alkoxy-4-(aryl)-5H-indeno[1,2-b]pyridine-3-carbonitriles (3a-e and 4a-e) were synthesized via multicomponent reaction from 2-aryl-methylidineindan-1-ones (1a-e), malononitrile and K2CO3 in ethanol and/or methanol. The structures of obtained compounds (3a-e and 4a-e) were characterized using the spectroscopic methods (NMR, IR) and elemental analysis. Addition, the in vitro antimicrobial activities of compounds (3a-e) were tested against the five human pathogenic bacteria. Penicillin G and Ceftriaxone antibiotics were used as positive control. The results were given as MIC values (minimum inhibition concentration), and compounds 3b-d showed very high activity against Escherichia coli 111. [ABSTRACT FROM AUTHOR]