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A previously undescribed phenolic glycoside (manglycoside A, 1), as well as 16 identified compounds (2-17), were isolated from the leaves and twigs of the 'vulnerable' plant Magnolia decidua (Magnoliaceae). Comprehensive spectroscopic investigation and chemical transformations revealed the structure of the previously unknown compound 1. Among the isolates, honokiol (6) and liriodenine (14) were discovered to exhibit antiinflammatory activities in LPS-induced RAW 264.7 cells via reducing nitric oxide (NO) formation, with IC50 values of 4.3 and 17.3 µM, correspondingly. [ABSTRACT FROM AUTHOR]

A pair of unique diastereoisomers of norlignan glycosides named cephalotanols A (1) and B (2), together with two known compounds, have been isolated from the twigs and leaves of Cephalotaxus fortunei Hook. Their structures were elucidated by using a combination of spectroscopic techniques and comparison of experimental and calculated electronic circular dichroism (ECD) data. To our knowledge, cephalotanols A and B represent the first rearranged norlignan glycosides with diphenylvinylcyclopropane core found in natural sources, of which biosynthetic pathways originating from co-occurring precursors 3S-4"-O-β-D -glucopyranosylhinokiresinol (3) and 3S-4"-O-β-D -glucopyranosylhinokiresinol (4) via di-π-methane rearrangement is proposed. [ABSTRACT FROM AUTHOR]