1. Association between Apolipoprotein E-polymorphism and Ischemic Heart Disease Patients With or Without Type 2 Diabetes Mellitus: A Preliminary Study in Kuwait.
- Author
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Al-Majed, Hana T., Qasem, Jafar A., Al-Sherifi, Ahmed K., Al-Attar, Abdulnabi A., Qasem, Abdulla A., and Abdullah, Salwa A.
- Subjects
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CORONARY disease , *DIAGNOSIS , *HEART disease diagnosis , *PREVENTION of heart diseases , *HEART disease risk factors , *ISCHEMIA diagnosis , *DNA , *APOLIPOPROTEINS , *CHI-squared test , *PEOPLE with diabetes , *GENES , *GENETIC polymorphisms , *MEDICAL care , *MEDICAL needs assessment , *TYPE 2 diabetes , *PATIENTS , *POLYMERASE chain reaction , *DATA analysis , *DATA analysis software , *PHYSIOLOGY - Abstract
Background: We investigated the association between apolipoprotein E polymorphism and ischemic heart disease with or without type 2 diabetes in Kuwait and examined the impact of apolipoprotein E polymorphism in diabetic patients. Methods: The present study was conducted from January 2005 to June 2006 in the Diabetic Clinic of Al-Amiri and Al-Sabah Hospitals in Kuwait City. Apolipoprotein E polymorphism was assessed in 250 subjects of which 83 were ischemic heart disease patients (41 diabetic and 42 non-diabetic) and 105 were diabetic patients without ischemic heart disease. Results were compared with 62 healthy controls. Apolipoprotein E polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism. Results: Apolipoprotein E3 allele was the most commonly occurring form. The frequency of apolipoprotein E4 was higher in ischemic heart disease patients with type 2 diabetes (39%) and the non-diabetic (31%) group, but lower in the diabetic (20%) and control groups (16%). Conclusion: Apolipoprotein E4 allele may be related to the development of ischemic heart disease in patients with or without type 2 diabetes in Kuwait. However, future studies with larger population sizes are needed to establish such relationship. [ABSTRACT FROM AUTHOR]
- Published
- 2011