1. Complement factor H and related proteins in age-related macular degeneration.
- Author
-
Calippe B, Guillonneau X, and Sennlaub F
- Subjects
- Aging physiology, Blood Proteins genetics, Blood Proteins physiology, Complement C3b Inactivator Proteins genetics, Complement C3b Inactivator Proteins physiology, Humans, Macular Degeneration genetics, Complement Factor H genetics, Macular Degeneration drug therapy
- Abstract
Age-related macular degeneration (AMD) is the major cause of legal blindness in the industrialized world. Polymorphisms and recently discovered rare mutations of the Complement Factor H gene have been shown to be strongly associated with AMD. The deletion of CFH-related proteins 1 and 3, proteins that share homologous regions with CFH, is found in protective haplotypes. The following is a critical review of the current state of knowledge of the implication of CFH and CFH-related proteins 1 and 3 in AMD., (Copyright © 2014. Published by Elsevier SAS.)
- Published
- 2014
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