1. Embryonic expression of the leptin receptor gene in mesoderm-derived tissues.
- Author
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Camand O, Turban S, Abitbol M, and Guerre-Millo M
- Subjects
- Animals, Carrier Proteins genetics, Cartilage embryology, Cartilage metabolism, Connective Tissue embryology, Connective Tissue metabolism, Eye growth & development, Eye metabolism, Eye Proteins biosynthesis, Eye Proteins genetics, Fetal Proteins genetics, Gestational Age, Hematopoietic System embryology, Hematopoietic System metabolism, In Situ Hybridization, Mice, Muscle Proteins biosynthesis, Muscle Proteins genetics, Muscle, Smooth embryology, Muscle, Smooth metabolism, Nerve Tissue Proteins biosynthesis, Nerve Tissue Proteins genetics, Organ Specificity, Receptors, Leptin, Carrier Proteins biosynthesis, Fetal Proteins biosynthesis, Gene Expression Regulation, Developmental, Leptin physiology, Mesoderm metabolism, Receptors, Cell Surface
- Abstract
Leptin acts on the hypothalamus to reduce food intake and on a number of non-neuronal tissues via specific receptors (Lepr). The use of in situ hybridisation to map the Lepr gene in pre-natal mice revealed transcripts in the yolk sac in various structures of the central nervous system and in mesoderm-derived tissues, such as cartilage/bone primordia and musculoaponeurotic laminae. At later stages, significant amounts of Lepr were expressed in the region surrounding the developing eye of the embryo. Lepr was also found to be expressed in the choroid, sclera and connective tissues of the limbus in the adult eye. In conclusion, we have identified new targets for leptin action during embryogenesis and adulthood.
- Published
- 2002
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