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Start Over Descriptor "mox-ldl" Publisher academic press inc.
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1. Oxidation of low density lipoproteins by myeloperoxidase at the surface of endothelial cells: an additional mechanism to subendothelium oxidation

Author

Zouaoui Boudjeltia, K., Moguilevsky, N., Legssyer, I., Babar, S., Guillaume, M., Delree, P., Vanhaeverbeek, M., Brohee, D., Ducobu, J., and Remacle, C.

Subjects
*CELLULAR mechanics, *LOW density lipoproteins, *PROTEINS, *PEROXIDASE
Abstract

The present paradigm of atherogenesis proposes that low density lipoproteins (LDL) are trapped in subendothelial space of the vascular wall where they are oxidized. Myeloperoxidase (MPO) plays a key role in oxidative damage. We propose that LDL oxidation by myeloperoxidase (Mox-LDL) could occur at the surface of the endothelial cells and not restricted to the subendothelial space. The triad constituted by endothelial cells, circulating LDL and MPO in close interaction, constitutes a synergic mechanism for the genesis of Mox-LDL. [Copyright &y& Elsevier]

Published
2004
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