1. Taking into account nucleosomes for predicting gene expression.
- Author
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Teif, Vladimir B., Erdel, Fabian, Beshnova, Daria A., Vainshtein, Yevhen, Mallm, Jan-Philipp, and Rippe, Karsten
- Subjects
- *
CHROMATIN , *GENETIC regulation , *DYNAMIC programming , *ADENOSINE triphosphate , *NUMERICAL calculations , *CHROMOSOMES - Abstract
Highlights: [•] Assumptions used for bottom-up modeling of gene regulation are critically reviewed. [•] Dynamic programming method to calculate TF binding in chromatin is described. [•] Model parameterization requires both sequencing methods and life cell imaging. [•] TF binding to partially unwrapped nucleosomes needs to be taken into account. [•] ATP-dependent action of chromatin remodelers needs to be taken into account. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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