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A novel CoMoO 4 -RuO 2 heterogeneous catalyst with flower-liked morphology was developed as a highly efficient bifunctional oxygen electrocatalyst for Zn-air battery. [Display omitted] Constructing heterogeneous catalysts can significantly boost the electrocatalytic activity due to the improved intrinsic catalytic activity induced by tailored electronic structure and optimized chemisorption to the reaction intermediates. RuO 2 based electrocatalysts are especially attractive due to the high catalytic activity of RuO 2. To reduce the usage of noble metal and improve the catalytic activity of catalyst, CoMoO 4 -RuO 2 micro-flower was synthesized using a facile hydrothermal-calcination method in this work. CoMoO 4 -RuO 2 exhibits a low overpotential of 177 mV at 10 mA cm−2 for oxygen evolution reaction (OER) and a high half-wave potential of 0.858 V for oxygen reduction reaction (ORR). Moreover, the Zn-air battery assembled using CoMoO 4 -RuO 2 exhibit shows a high maximum discharge power density of 149 mW cm−2 and a large open circuit voltage of 1.38 V. The good performance can be attributed to the incorporation of RuO 2 , which not only induces extra catalytic active sites, but also forms heterojunction with CoMoO 4 to optimize the electronic structure of CoMoO 4 -RuO 2 , thereby achieving a better equilibrium of absorption and desorption of intermediates. The work provides insights into designing RuO 2 based electrocatalysts for advanced electrocatalysis. [ABSTRACT FROM AUTHOR]

With the acceleration of industrialization, Cd pollution has emerged as a major threat to soil ecosystem health and food safety. Hyperaccumulating plants like Sedum alfredii Hance are considered to be used as part of an effective strategy for the ecological remediation of Cd polluted soils. This study delved deeply into the physiological, transcriptomic, and metabolomic responses of S. alfredii under cadmium (Cd) stress when treated with exogenous salicylic acid (SA). We found that SA notably enhanced the growth of S. alfredii and thereby increased absorption and accumulation of Cd, effectively alleviating the oxidative stress caused by Cd through upregulation of the antioxidant system. Transcriptomic and metabolomic data further unveiled the influence of SA on photosynthesis, antioxidant defensive mechanisms, and metal absorption enrichment pathways. Notably, the interactions between SA and other plant hormones, especially IAA and JA, played a central role in these processes. These findings offer us a comprehensive perspective on understanding how to enhance the growth and heavy metal absorption capabilities of hyperaccumulator plants by regulating plant hormones, providing invaluable strategies for future environmental remediation efforts. • Exogenous SA significantly enhances the growth, stress tolerance, and Cd uptake/accumulation in S. alfredii. • S. alfredii exhibited the best Cd remediation when treated with 100 μmol/L SA. • SA upregulated genes related to photosynthesis, antioxidant systems, and Cd uptake/accumulation. • The interaction of plant hormones is crucial for the growth, stress resilience, and Cd uptake in S. alfredii. [ABSTRACT FROM AUTHOR]

[Display omitted] • Hollow CoVO x /Ag heterojunction was synthesized for OER. • The interaction of CoVO x and Ag nanoparticles regulated the electronic structure. • The extrinsic catalytic activity of CoVO x /Ag is enhanced due to the hollow structure. • The OER overpotential for CoVO x /Ag-5 at 10 mA cm−2 is only 247 mV. • The catalyst can enable full water splitting with 100% Faraday efficiency. Developing high-active and inexpensive electrocatalysts for oxygen evolution reaction (OER) is very important in the field of water splitting. The catalytic performance of electrocatalysts can be significantly improved by optimizing the electronic structure and designing suitable nanostructure. In this work, we represent the synthesis of hollow CoVO x /Ag-5 for OER. Due to the interaction of CoVO x and Ag nanoparticles, the electronic structure is optimized to improve the intrinsic catalytic activity. Additionally, the extrinsic catalytic activity of CoVO x /Ag is enhanced by the abundant active sites from the hollow structure. As a result, the CoVO x /Ag-5 demonstrates significantly enhanced OER catalytic activity with a low overpotential of 247 mV at 10 mA cm−2. In addition, it also exhibits excellent durability, without obvious attenuation in performance after continuous operation for 60 h. Furthermore, the catalyst can enable full water splitting with appropriate 100 % Faraday efficiency, demonstrating its practical application. [ABSTRACT FROM AUTHOR]

Previous studies have shown that sepsis is implicated in a reduction in the number and function of CD4+ T cells. TCF7 and LEF-1 facilitate early T cell development and lineage selection of CD4+ T cells. However, the function and mechanism of TCF7 and LEF-1 in sepsis are uncharacterized. This study intended to delineate effect of TCF7 and LEF-1 on sepsis and the impact on proliferation of CD4+ T cells in sepsis. A mouse sepsis model was constructed by cecal ligation and puncture (CLP) method. Expression of TCF7 and LEF-1 in sepsis was investigated using bioinformatics analysis and molecular experiments. We then constructed TCF7 and LEF-1 overexpression cell lines to investigate their effects on proliferation, apoptosis, effector activation, and immunosuppressive molecules of CD4+ T cells in sepsis. TCF7 and LEF-1 were downregulated in sepsis. As the duration of sepsis induction increased, the levels of TCF7 and LEF-1 gradually decreased, as did the number of CD4+ T cells. Cell experiments showed that overexpression of TCF7 and LEF-1 enhanced proliferation and effector activation of CD4+ T cells, reduced apoptosis, decreased PD-1 and LAG3 expression, and promoted immune response in sepsis. In conclusion, this study confirmed that downregulation of TCF7 and LEF-1 expression in sepsis inhibited proliferation of CD4+ T cells, leading to immune suppression. This finding suggested that TCF7 and LEF-1 were potential biological targets for sepsis and indicated that immunotherapy aimed at improving CD4+ T cell proliferation may be a new strategy for immune therapy in sepsis patients. • TCF7 and LEF-1 are downregulated in sepsis. • TCF7 and LEF-1 inhibited CD4+T cells activity. • TCF7 and LEF-1 reduced immune response. [ABSTRACT FROM AUTHOR]