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[Display omitted] Long-term exposition of electrodes to aqueous media inevitably results in biofouling and adhesion of bacteria, reducing the electrolysis efficiency of electrodes for water treatment. To ensure technically efficient antifouling of materials for durable electrodes, hierarchical micro-/nano structured boron-doped diamond (BDD) electrodes were designed and synthesized. Multi-level structured BDD was coated on titanium mesh by a bottom-up strategy, based on a combination of self-assembly seeding and hot filament chemical vapor deposition (HFCVD) growth. The morphology of the BDD coating can be controlled by manipulating the seeding density and boron doping concentration. The designed micro/nano hierarchical structure of the BDD electrode suppressed bacterial adhesion greatly and exhibited excellent anti-biofouling efficiency with an antibacterial rate of ∼ 93 %, which entails simplified self-cleaning and durable BDD-coated electrodes. The BDD-coated electrodes were employed to electrochemically treat Escherichia coli -contaminated water, killing virtually all bacteria (≥99.9 %) in 1 min. Finally, real river water was electrochemically treated, reducing the chemical oxygen demand (COD) down to 5 mg/L in 4 h. The excellent performance shows the great potential of the structured BDD electrodes for long-term water purification. [ABSTRACT FROM AUTHOR]

The mesenchymal (MES) subtype of glioblastoma (GBM) suggested worse prognosis and a more malignant phenotype in comparison with their proneural (PN) counterpart. The plasticity between PN and MES transcriptome signatures provided clinical intervention with an manner. Few LncRNA, however, have been discovered to take part in the shift between subtypes. Here, we used transcriptomic data and experimental evidences to demonstrate that silencing LncRNA LOXL1-AS1 was a new regulator of NF-κB signaling pathway through repressing RELB directly, resulting in increased marker genes of PN subtype and decreased those of MES.GBM cell proliferation was functionally suppressed by LOXL1-AS1 's knockdown expression,. Furthermore, RELB's rescue could reverse LOXL1-AS1 's effects partially in GBM malignant behaviors. LOXL1-AS1 could clinically serve as a poor prognostic indicator for GBM patients. In conclusion, our results suggest that LOXL1-AS1 contributes to aggressive biological processes that are related with MES phenotype via NF-κB signaling, which expand our perceptions into the underlying mechanisms in LOXL1-AS1 -based and subtype transition adapted medicine for GBM management. [ABSTRACT FROM AUTHOR]

Abstract: Power harvesting techniques that convert vibration energy into electrical energy through piezoelectric transducers show strong potential for powering smart wireless sensor devices in applications of structural health monitoring. This paper presents an analytical model of the dynamic behavior of an electromechanical piezoelectric bimorph cantilever harvester connected with an AC–DC circuit based on the Euler–Bernoulli beam theory and Hamiltonian theorem. A new cantilevered piezoelectric bimorph structure is proposed in which the plug-type connection between support layer and tip-mass ensures that the gravity center of the tip-mass is collinear with the gravity center of the beam so that the brittle fracture of piezoelectric layers can also be avoided while vibrating with large amplitude. The tip-mass is equated by the inertial force and inertial moment acting at the end of the piezoelectric bimorph beam based on D''Alembert''s principle. An AC–DC converting circuit soldered with the piezoelectric elements is also taken into account. A completely new analytic expression of the global behavior of the electromechanical piezoelectric bimorph harvesting system with AC–DC circuit under input base transverse excitation is derived. Moreover, an experimental energy harvester is fabricated and the theoretical analysis and experimental results of the piezoelectric harvester under the input base transverse displacement excitation are validated by using measurements of the absolute tip displacement, electric voltage response, electric current response and electric power harvesting. [Copyright &y& Elsevier]