1. Inflammation-inducing Th1 and Th17 cells differ in their expression patterns of apoptosis-related molecules
- Author
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Tan, Cuiyan, Ramaswamy, Madhu, Shi, Guangpu, Vistica, Barbara P., Siegel, Richard M., and Gery, Igal
- Subjects
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TH1 cells , *INFLAMMATION , *GENE expression , *APOPTOSIS , *CELL death , *MESSENGER RNA - Abstract
Abstract: Th1 cells are remarkably more susceptible to activation induced cell death than Th17. Here, we compared cultures of these two cell subpopulations for their expression of apoptosis-related molecules when re-exposed to their specific antigen. We also compared the expression of apoptosis-related molecules in the mouse eye with inflammation induced by Th1 or Th17 cells. Using qPCR we found that the mRNA transcript levels of the majority of tested apoptosis-related molecules were higher in the Th1 cultures, and in eyes with Th1-induced inflammation. Apoptotic intrinsic pathway molecules played minor roles in the processes in vitro or in vivo, whereas extrinsic pathway molecules, as well as PD-1, its ligands and Tim3, were heavily involved. [Copyright &y& Elsevier]
- Published
- 2011
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