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Excessive carbon dioxide (CO 2) emissions from flue gases intensify the greenhouse effect. Exploring porous adsorbents with high CO 2 /N 2 selectivity is of great significance to reducing the CO 2 content in flue gases. Herein, we report a novel PtS-type metal-organic framework (MOFs), termed ZSTU-21, with narrow pore size and excellent CO 2 /N 2 separation performance with dual open copper sites. At 298 K, ZSTU-21 exhibits a CO 2 uptake capacity of 62 cm3 g−1 and a high selectivity of 105 for CO 2 /N 2 (CO 2 /N 2 = 15/85, v/v). Multicomponent adsorption breakthrough experiments further verified the superior performance of ZSTU-21 MOF in CO 2 /N 2 separation. Moreover, the synthesis of ZSTU-21 MOF can be carried out under mild experimental conditions at room temperature, making the process simple and cost-effective, thus laying a solid foundation for its widespread application in CO 2 /N 2 separation. A novel PtS-type metal-organic framework (MOFs), termed ZSTU-21, with narrow pore size and excellent CO 2 /N 2 separation performance with dual open copper sites was reported. [Display omitted] • Cu-MOF (ZSTU-21) with two different pore sizes was successfully synthesized at room temperature. • CO 2 /N 2 selectivity was achieved by introducing open metal ions. • ZSTU-21 exhibits high adsorption performance for CO 2 and good separation performance for CO 2 /N 2 capture. [ABSTRACT FROM AUTHOR]

Carbon dioxide capture from flue gas (CO 2 /N 2) and natural gas (CO 2 /CH 4) is a challenging and cost-effective task. In this paper, ultramicroporous metal-organic frameworks (MOFs) (Co-norf and Ni-norf) are synthesized to realize the efficient separation of CO 2 /N 2 and CO 2 /CH 4 by metal ion regulation. The Ideal Adsorption Solution Theory (IAST) was calculated to evaluate the adsorption selectivity of activated Co-norf and Ni-norf for CO 2 /N 2 (v/v = 15/85) mixtures and CO 2 /CH 4 mixtures. The CO 2 /N 2 selectivity of Co-norf and Ni-norf at 100 kPa was 734 and 96, respectively, which corresponds to an almost 7.6-fold increase by metal ion modulation. The specific binding sites of CO 2 molecules within the pore channels were obtained by grand canonical Monte Carlo simulation (GCMC). Dynamic breakthrough experiments respond to the actual separation in systems simulating flue gas and natural gas, where the higher saturation adsorption and longer retention time proved that Co-norf is an ideal material for CO 2 capture and separation. The present work provides a feasible approach for the application of MOF in gas separation. The regulation of metal ions on MOF channels is proved through single-component gas adsorption experiment, IAST selective calculation and dynamic breakthrough, which provides an effective way for the application of MOF materials in the field of gas separation. [Display omitted] • The successful synthesis of Co-norf and Ni-norf MOFs with ultramicroporous structures. • Enhanced CO 2 /N 2 and CO 2 /CH 4 selectivities achieved through metal ion regulation. • Co-norf demonstrated high separation performance for CO 2 /N 2 captures. [ABSTRACT FROM AUTHOR]

Gastric cancer (GC) is a common cancer type with both high incidence and mortality. Recent studies have revealed an important role of circRNA in the development of GC. However, more experiments are needed to reveal the precise molecular mechanisms of circRNA in GC development. Bioinformatics analysis was conducted to predict the potential role of circ_PABPC1 in GC and the target proteins of circ_PABPC1. Quantitative RT-PCR, Western blot and immunohistochemistry assays were conducted to detect the levels of circ_PABPC1, NF-κB p65, NF-κB p65 (Ser536) and ILK. MTT, Edu staining, cell scratch-wound and trans -well assays were carried out to detect cell proliferation, migration and invasion. The interaction between ILK and circ_PABPC1 was confirmed by RNA immunoprecipitation (RIP), RNA pull-down and fluorescence in situ hybridization assays. Genetically modified GC cells were injected into mice to evaluate the tumor growth performance. This study found that the high expression of circ_PABPC1 was associated with a poor prognosis of GC. The up-regulation of circ_PABPC1 promoted the proliferation, migration and invasion of GC cells. Circ_PABPC1 bound to ILK protein, thereby preventing the degradation of ILK. ILK mediated the effect of circ_PABPC1 on GC cells through activating NF-κB. circ_PABPC1 promotes the malignancy of GC cells through binding to ILK to activate NF-κB signaling pathway. [ABSTRACT FROM AUTHOR]