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With growing consumer concern regarding food quality and composition. This study was performed to analyze the content of major inorganic nutrients, trace elements, potentially toxic elements and ash content in 48 saffron samples. These were collected from four distinct Moroccan regions: "Taliouine, Taznakht, Azilal, and Beni Mellal". The analysis was done in accordance with the guidelines set by the Association of Official Agricultural Chemists (AOAC). The findings of this study reveal that essential nutrient elements such as magnesium, phosphorus, calcium, potassium, and sodium were present in important amounts. The average content of these macro-elements was found in the following order: K > P > Mg > Ca > Na, with mean concentrations of 16500±1119 mg/kg, 3290±220 mg/kg, 1430±97 mg/kg, 960±65 mg/kg, and 75±5 mg/kg, respectively. Significant differences among sampling sites as revealed by ANOVA and principal component analysis in selected samples. Furthermore, the levels of potentially harmful elements, including nickel, arsenic, lead, and cadmium, were found below the harmful limits. These results provide valuable scientific information that supports the optimal utilization of saffron, enriching the medicinal plant database. This research sheds light on the compositional, nutritional, and safety aspects of saffron, laying the groundwork for future research in this field. [Display omitted] • Detected vital minerals/nutrients like Mg, P, Ca, K, and Na in Moroccan saffron. • Assessed trace metals Ni, As, Pb, Cd below safety thresholds/levels. • Examined saffron from Taliouine, Taznakht, Azilal, Beni Mellal. • Utilized ICP-OES for accurate mineral and heavy metal analysis/quantification. • Provided evidence for saffron's potential as a dietary and medicinal value/supplement. [ABSTRACT FROM AUTHOR]