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Hippo signaling pathway is an evolutionarily conserved developmental network that governs the downstream transcriptional co-activators, YAP and TAZ, which bind to and activate the output of TEADs that responsible for cell proliferation, apoptosis, and stem cell self renewal. Emerging evidence has shown the tumor suppressor properties of Hippo signaling. However, limited knowledge is available concerning the downstream transcription factors of Hippo pathway in osteosarcoma (OS). In this study, we demonstrated that TEAD1 was the major transcription factor of Hippo signaling pathway in OS. Genetic silencing of TEAD1 suppressed multiple malignant phenotypes of OS cells including cell proliferation, apoptosis resistance, and invasive potential. Mechanistically, we showed that TEAD1 largely exerted its transcriptional control of its functional targets, PTGS2 and CYR61. Collectively, this work identifies the YAP1/TEAD1 complex as the representative dysregulated profile of Hippo signaling in OS and provides proof-of-principle that targeting TEAD1 may be a therapeutic strategy of osteosarcoma. [ABSTRACT FROM AUTHOR]

The molybdenum phosphide (MoP) nanoparticles supported by phosphorus and nitrogen co-doped carbon nanosheet (N, P–C) have been prepared through simple one-step calcination method. The composition and morphology of the prepared hybrids were further characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and so on. The characterization results prove that the annealing temperature plays an essential role in the fabrication of nanosheets morphology. All characterization results prove that the MoP nanoparticles were uniformly loaded on N,P–C nanosheets. As excepted, the unique nanosheet structure not only contributes to mass transfer and electron transfer, but also increases electrochemical surface area. The obtained MoP/N,P–C-900 composites exhibit excellent HER activity and long-time stability (η ​= ​129 ​mV for reaching 10 ​mA ​cm−2 and 10 ​h for successive testing), which is superior than many other non-precious metal electrocatalysts. The present work affords a promising strategy for designing novel HER electrocatalysts, which may be applied in storage systems and diverse energy conversion. The molybdenum phosphide (MoP) nanoparticles supported by phosphorus and nitrogen co-doped carbon nanosheet (N, P–C) have been prepared through simple one-step calcination method. The performance is comparable to most of non-precious-based metal electrocatalysts under same conditions, suggesting that the rationality of nanosheet architectures. Image 1 [ABSTRACT FROM AUTHOR]