3 results on '"Guan, Wei-Jie"'
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2. Exposure to biomass fuel is associated with high blood pressure and fasting blood glucose impairment in females in southern rural China.
- Author
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Zheng, Xue-yan, Tang, Si-li, Guan, Wei-jie, Ma, Shu-li, Li, Chuan, Xu, Yan-jun, Meng, Rui-lin, and Lin, Li-feng
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HYPERTENSION , *BLOOD sugar , *HDL cholesterol , *BLOOD pressure , *BIOMASS , *RURAL electrification - Abstract
We sought to investigate the association between household exposure to biomass fuel and metabolic syndrome (MetS) and its components including blood pressure, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG) and waist circumference among females in southern rural China. We surveyed 1664 residents in the Chronic Disease and Risk Factors Surveillance , conducted in 14 districts of Guangdong province. We recorded the use of biomass fuel, MetS and its components, and other covariates by using a structured questionnaire. Logistic regression model and multivariate linear regression model were adopted for analysis. Exposure to biomass fuel was significantly associated with an increase of systolic blood pressure (SBP) (β: 2.15, 95% confidence interval: 0.13 to 4.17) and FBG (β: 0.19, 95% confidence interval: 0.01 to 0.37) in the adjusted and unadjusted models (all P < 0.05). Among participants with exposure to biomass fuel, being overweight or obese was associated with an increased risk of having hypertension (odds ratio: 3.19, 95% confidence interval: 2.13 to 4.76) and higher FBG levels (odds ratio: 2.10, 95% confidence interval: 1.46 to 3.02). Exposure to biomass fuel was significantly associated with a decrease of the prevalence of central obesity (P < 0.05). However, exposure to biomass fuel was not associated with MetS, diastolic blood pressure and TG (all P > 0.05). Exposure to biomass fuel is associated with an increase in blood pressure and FBG levels, but not MetS per se. Efforts should be made to protect females in southern rural China from the adverse effects associated with biomass fuel pollution. • This is the first study delineating the association between biomass fuel and multiple MetS components. • Biomass fuel was associated with increased blood pressure and FBG. • Overweight or obese women who were exposed to biomass fuel had a higher risk of hypertension. • Higher FBG associated with biomass fuel exposure was detected in overweight or obese participants. • Biomass fuel exposure was not associated with the development of MetS. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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3. Effect of tiotropium on neural respiratory drive during exercise in severe COPD.
- Author
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Qin, Yin-Yin, Li, Rui-Fa, Wu, Guo-Feng, Zhu, Zheng, Liu, Jie, Zhou, Cheng-Zhi, Guan, Wei-Jie, Luo, Jia-Ying, Yu, Xin-Xin, Ou, Yang-Ming, Jiang, Mei, Zhong, Nan-Shan, and Luo, Yuan-Ming
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OBSTRUCTIVE lung disease treatment , *TREATMENT of dyspnea , *PARASYMPATHOMIMETIC agents , *SPIROMETRY , *ELECTROMYOGRAPHY , *EXERCISE tolerance - Abstract
Background Studies have shown that tiotropium once daily reduces lung hyperinflation and dyspnea during exercise and improves exercise tolerance in patients with COPD. Mechanisms underlying the effects of the muscarinic receptor antagonist tiotropium on COPD have not been fully understood. Objective In this study, we investigated whether improvement in neural respiratory drive is responsible for reducing dyspnea during exercise and improving exercise tolerance in COPD. Methods Twenty subjects with severe COPD were randomized into two groups: no treatment (Control, n = 10, 63.6 ± 4.6 years, FEV 1 29.6 ± 13.3%pred) or inhaled tiotropium 18 μg once daily for 1 month ( n = 10, 66.5 ± 5.4 years, FEV 1 33.0 ± 11.1%pred). All subjects were allowed to continue their daily medications other than anti-cholinergics during the study. Constant cycle exercise with 75% of maximal workload and spirometry were performed before and 1 month after treatment. Diaphragmatic EMG (EMGdi) and respiratory pressures were recorded with multifunctional esophageal catheter. Efficiency of neural respiratory drive, defined as the ratio of minute ventilation (VE) and diaphragmatic EMG (VE/EMGdi%max), was calculated. Modified British Medical Research Council Dyspnea Scale (mMRC) was used for the evaluation of dyspnea before and after treatment. Results There was no significant difference in spirometry before and after treatment in both groups. Diaphragmatic EMG decreased significantly at rest (28.1 ± 10.9% vs. 22.6 ± 10.7%, P < 0.05) and mean efficiency of neural respiratory drive at the later stage of exercise increased (39.8 ± 2.9 vs. 45.2 ± 3.9, P < 0.01) after 1-month treatment with tiotropium. There were no remarkable changes in resting EMGdi and mean efficiency of neural respiratory drive post-treatment in control group. The score of mMRC decreased significantly (2.5 ± 0.5 vs. 1.9 ± 0.7, P < 0.05) after 1-month treatment with tiotropium, but without significantly difference in control group. Conclusion Tiotropium significantly reduces neural respiratory drive at rest and improves the efficiency of neural respiratory drive during exercise, which might account for the improvement in exercise tolerance in COPD. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
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