1. Evaluation of CD4+CD25+FoxP3+ T cell populations, IL-10 production, and their correlation with clinical and biochemical parameters in sickle cell anemia patients with leg ulcers.
- Author
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Rêgo, Moacyr Jesus Barreto Melo, da Silva, Rafael Ramos, Pereira, Michelly Cristiny, da Silva Araújo, Aderson, Pitta, Ivan da Rocha, Falcão, Diego Arruda, Bezerra, Marcos André Cavalcanti, and Pitta, Maira Galdino da Rocha
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CD4 antigen , *T cells , *INTERLEUKIN-10 , *PARAMETER estimation , *SICKLE cell anemia , *PATIENTS ,LEG ulcers - Abstract
Leg ulcers (LUs) are a debilitating complication of sickle cell anemia (SCA), with inflammation known to play a crucial role in their pathogenesis. Many studies have described the roles of T helper type 1 (Th1) and Th2 pathways in SCA; however, defects in anti-inflammatory responses are poorly understood. We evaluated interleukin (IL)-10 levels in serum and peripheral blood mononuclear cells (PBMCs) in SCA patients with leg ulcers (SCALU) and without leg ulcers (SCAWH) in addition to CD4 + CD25 + FoxP3 + T cell populations and their its IL-10 expression. In stimulated and unstimulated PBMC cultures, SCALU patients produced higher levels of IL-10 than those in the SCAWH group. Higher levels of IL-10 in SCALU patients correlated with a history of osteonecrosis in stimulated and unstimulated cultures when compared with those in SCAWH. Immunophenotyping revealed that SCALU patients had a higher proportion of CD4 + CD25 + FoxP3 + , Tr1 and CD4 + CD25 + FoxP3 + IL-10 + T cells than other groups. Our findings revealed that IL-10 levels were increased in unstimulated cells from the SCALU group, and that this group also presented with a predominant CD4 + CD25 + FoxP3 + cell population despite many of those cells being IL-10 negative. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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