Search

To determine the association of peroxisome proliferator activated receptor gamma coactivator 1 Gly482Ser variant with components of metabolic syndrome. A systematic search was carried out using Web of Science, PubMed, EMBASE and the Cochrane library using the key words: Peroxisome proliferator activator receptor gamma coactivator 1, PPARGC1A, PGC-1, PGC-1alpha, and PGC1alpha alone or with polymorphism, Gly482Ser and rs8192678. Data from 19 articles generated 28 separate data sets. Under the recessive model fasting plasma glucose was significantly lower in AA genotypes when compared to GG + GA in the total sample group and in non-Asian group (p <.001). The AA genotype showed significantly lower levels of total cholesterol compared to GG + GA genotype using the recessive model with the non-Asian group (p <.05). Under the dominant model, body mass index of the GG genotype was significantly higher in Asian subgroups (p <.05). PPARGC1A Gly482Ser variant impacts differently in Asian population groups. • This is the first meta-analysis where cholesterol has been used as an indicative element in the data search strategy for this variant; • The work demonstrates a genetic distinction at the level of the BMI between the Asian and non-Asian population groups; • AA genotype showed significantly lower levels of total cholesterol compared to GG + GA genotype in the non-Asian population. [ABSTRACT FROM AUTHOR]

To investigate the association between circulating levels of adipocytokines (adiponectin, leptin, tumour necrosis factor alpha (TNFα), interleukin 6 (IL-6)) and growth factors (insulin-like growth factor I (IGF-I) and II (IGF-II)), and the risk of endometrial cancer. Cochrane, CINAHL, Embase, Medline and Web of Science were searched for English-language manuscripts published between January 2000 and August 2018 using the following string of words: cancer and endometrial and (obesity or BMI) and (adiponectin or TNF* or IGF-I or IGF-II or IL-6 or leptin). Twenty articles were included in this meta-analysis, which corresponded to 18 studies involving 2921 endometrial carcinoma cases and 5302 controls. Fourteen articles reported circulating levels for adiponectin, seven for leptin, three for TNFα, three for IL-6 and one for IGF-I. No article reported values for IGF-II. Patients with circulating adiponectin levels in the highest tertile had decreased endometrial cancer risk compared to women with levels in the lowest tertile, (summary of odds ratio (SOR) 0.51, 95% confidence interval (CI): 0.38–0.69, p < 0.00001). Women with circulating leptin concentrations in the highest tertile had increased endometrial cancer risk compared to women with concentrations in the lowest tertile (SOR 2.19, 95% CI: 1.45–3.30, p = 0.0002). There was no difference in cancer risk between participants with the highest TNFα and IL-6 levels compared to the lowest levels (SOR 1.27, 95% CI: 0.88–1.83, p = 0.20 and SOR 1.20, 95% CI: 0.89–1.63, p = 0.23, respectively). Endometrial cancer risk is inversely affected by adiponectin and leptin levels. There appears to be no relationship between TNFα and IL-6 and the overall risk of endometrial cancer. • Patients with lower adiponectin levels are more likely to develop endometrial cancer despite BMI, hypertension or diabetes. • When considering BMI or a history of diabetes, increased leptin levels confer a greater risk of endometrial cancer. • Larger studies are required to establish the role of TNFα and IL-6 in the development of endometrial cancer. [ABSTRACT FROM AUTHOR]