1. miR-128 and its target genes in tumorigenesis and metastasis.
- Author
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Li, Molin, Fu, Weiming, Wo, Lulu, Shu, Xiaohong, Liu, Fang, and Li, Chuangang
- Subjects
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MICRORNA , *GENE targeting , *NEOPLASTIC cell transformation , *CANCER invasiveness , *NUCLEOTIDE analysis , *GENE expression , *NERVOUS system development , *CANCER cell differentiation , *CANCER cell proliferation - Abstract
Abstract: MicroRNAs (miRNAs) are a class of endogenous, non-coding, 18–24 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis. [Copyright &y& Elsevier]
- Published
- 2013
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