1. Chronic exposure to metal fume PM2.5 on inflammation and stress hormone cortisol in shipyard workers: A repeat measurement study.
- Author
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Lai, Ching-Huang, Ho, Shu-Chuan, Pan, Chih-Hong, Chen, Wei-Liang, Wang, Chung-Ching, Liang, Che-Wi, Chien, Chi-Yu, Riediker, Michael, Chuang, Kai-Jen, and Chuang, Hsiao-Chi
- Subjects
SHIPYARDS ,HYDROCORTISONE ,METALS ,ADRENAL glands ,PARTICULATE matter - Abstract
Particulate matter with an aerodynamic diameter of ≤ 2.5 µm (PM 2.5) has been linked to adverse health outcomes in welding workers. The objective of this study was to investigate associations of chronic exposure to metal fume PM 2.5 in shipyard workers with health outcomes. A longitudinal study was conducted to determine the effects of metal fume PM 2.5 on FeNO, urinary metals, urinary oxidative stress, inflammation, and stress hormones in workers. There were 20 office workers and 49 welding workers enrolled in this study who were followed-up for a second year. We observed that Fe, Zn, and Mn were abundant in PM 2.5 to which welding workers were personally exposed, whereas PM 2.5 to which office workers were personally exposed was dominated by Pb, Cu, and Zn. We observed in the first and/or second visits that urinary 8-iso-prostaglandin F2-α (PGF2α) and 8-hydroxy-2′-deoxy guanosine (8-OHdG) were significantly increased by exposure. An increase in urinary interleukin (IL)-6 and decreases in urinary serotonin and cortisol were observed in the first and/or second visits after exposure. PM 2.5 was associated with decreases in urinary 8-OHdG and cortisol among workers. Next, we observed that urinary Ni, Co, and Fe had significantly increased among workers after a year of exposure. Urinary metals were associated with decreases in urinary 8-iso-PGF2α and cortisol among workers. Urinary Ni, Cu, and Fe levels were associated with an increase in urinary IL-6 and a decrease in urinary cortisol among workers. In conclusion, chronic exposure to metal fume PM 2.5 was associated with inflammation and a cortisol deficiency in shipyard workers, which could associate with adrenal glands dysfunction. [Display omitted] • Chronic effects of metal fume PM 2.5 in shipyard workers were studied. • Oxidative stress and inflammation was occurred by metal fume PM 2.5. • Urinary Ni, Cu and Fe was associated with a decrease in cortisol. • Adrenal glands dysfunction could be occurred in welders. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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