1. Vaccination with live attenuated simian immunodeficiency virus for 21 days protects against superinfection
- Author
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Stebbings, Richard, Berry, Neil, Stott, Jim, Hull, Robin, Walker, Barry, Lines, Jenny, Elsley, William, Brown, Stuart, Wade-Evans, Alison, Davis, Gail, Cowie, Jenny, Sethi, Meera, and Almond, Neil
- Subjects
- *
VACCINATION , *HIV , *PREVENTIVE medicine , *AIDS prevention - Abstract
The identification of mechanisms that prevent infection with human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) would facilitate the development of an effective AIDS vaccine. In time-course experiments, protection against detectable superinfection with homologous wild-type SIV was achieved within 21 days of inoculation with live attenuated SIV, prior to the development of detectable anti-SIV humoral immunity. Partial protection against superinfection was achieved within 10 days of inoculation with live attenuated SIV, prior to the development of detectable anti-SIV humoral and cellular immunity. Furthermore, co-inoculation of live attenuated SIV with wild-type SIV resulted in a significant reduction in peak virus loads compared to controls that received wild-type SIV alone. These findings imply that innate immunity or non-immune mechanisms are a significant component of early protection against superinfection conferred by inoculation with live attenuated SIV. [Copyright &y& Elsevier]
- Published
- 2004
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