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To determine the association of peroxisome proliferator activated receptor gamma coactivator 1 Gly482Ser variant with components of metabolic syndrome. A systematic search was carried out using Web of Science, PubMed, EMBASE and the Cochrane library using the key words: Peroxisome proliferator activator receptor gamma coactivator 1, PPARGC1A, PGC-1, PGC-1alpha, and PGC1alpha alone or with polymorphism, Gly482Ser and rs8192678. Data from 19 articles generated 28 separate data sets. Under the recessive model fasting plasma glucose was significantly lower in AA genotypes when compared to GG + GA in the total sample group and in non-Asian group (p <.001). The AA genotype showed significantly lower levels of total cholesterol compared to GG + GA genotype using the recessive model with the non-Asian group (p <.05). Under the dominant model, body mass index of the GG genotype was significantly higher in Asian subgroups (p <.05). PPARGC1A Gly482Ser variant impacts differently in Asian population groups. • This is the first meta-analysis where cholesterol has been used as an indicative element in the data search strategy for this variant; • The work demonstrates a genetic distinction at the level of the BMI between the Asian and non-Asian population groups; • AA genotype showed significantly lower levels of total cholesterol compared to GG + GA genotype in the non-Asian population. [ABSTRACT FROM AUTHOR]