1. Analysis of human papillomavirus 16 variants and risk for cervical cancer in Chinese population.
- Author
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Hang, Dong, Yin, Yin, Han, Jing, Jiang, Jie, Ma, Hongxqia, Xie, Shuanghua, Feng, Xiaoshuang, Zhang, Kai, Hu, Zhibin, Shen, Hongbing, Clifford, Gary M., Dai, Min, and Li, Ni
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PAPILLOMAVIRUS disease diagnosis , *CERVICAL cancer , *CERVICAL cancer patients , *CHINESE people , *POPULATION health , *CANCER invasiveness , *CANCER risk factors , *DISEASES - Abstract
HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervical cancer patients and 85 controls (all HPV16-positive). HPV16 isolates were predominantly of the A variant lineage, and variants of A4 (previously named “Asian”) sublineage were common. A4/Asian variants were significantly associated with increased risk of cervical cancer compared to A1–3 (OR=1.72, 95% CI=1.04–2.85). Furthermore, a meta-analysis including 703 cases and 323 controls from East Asia confirmed the association (OR=2.82, 95% CI=1.44–5.52). In conclusion, A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women, which may provide clues to the genetic basis of differences in the carcinogenicity of HPV16 variants. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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