1. Shared genetic etiology and antagonistic relationship of plasma renin activity and systolic blood pressure in a Korean cohorts.
- Author
-
Jung, Jaehoon and Kim, Heebal
- Subjects
- *
SYSTOLIC blood pressure , *BLOOD pressure , *RENIN , *GENETIC correlations , *KOREANS , *RENIN-angiotensin system , *ETIOLOGY of diseases - Abstract
Despite extensive studies on blood pressure, its genetic risk factors remain uncertain. Even one of the most researched blood pressure-related traits - renin - is not fully understood genetically. Here, we determine the genetic relationship and associated predisposition between blood pressure and baseline renin. In 8840 Korean individuals, we observed a strong negative genome-wide genetic correlation (r g = −0.484) between systolic blood pressure (SBP) and plasma renin activity (PRA), suggesting that antagonistic genetic signals explain the variance in the two traits. We found 51 significant pleiotropic SNPs affecting the two traits, which could contribute to the Renin-Angiotensin-Aldosterone System (RAAS). Our findings provide insight into studies on RAAS by identifying the genome-wide relationship and susceptibility loci of SBP and PRA. • Genome-wide significant SNPs were identified in GWAS on PRA. • Strong negative genome-wide genetic correlation between SBP and PRA was observed. • 51 pleiotropic SNPs were identified, which could contribute to the RAAS. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF