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Neuroimaging in Parkinson's Disease and Related Disorders discusses the advances of molecular, structural and functional neuroimaging techniques associated with the etiology, pathophysiology, effects and complications of novel therapies in Parkinson's and related disorders. With new neuroimaging methodologies emerging over the past five years, this book provides a comprehensive overview of new technologies and research. Sections discuss the biomarker value of neuroimaging of the brain to understand disease progression in vivo in actual patients with Parkinson's disease and related disorders. Readers will be updated on in vivo pathology and pathophysiology in Parkinson's disease and in a number of related disorders. Also discussed is the association between clinical symptoms, clinical progression, and molecular, structural, and functional changes in the brain of patients with Parkinson's disease and related disorders. - Comprehensive overview of biomarker value of neuroimaging of the brain to understand disease progression in vivo in actual patients with Parkinson's disease and related disorders - Helps readers understand the in vivo pathology and pathophysiology in Parkinson's disease and in a number of related disorders - Discusses the association between clinical symptoms, clinical progression, and molecular, structural, and functional changes in the brain of patients with Parkinson's and related disorders

Metabolic Bone Disease, Volume II describes the clinical disorders of bone and mineral metabolism characterized by elevated levels of circulating parathyroid hormone. This book emphasizes the relationship between hormonal synthesis, biological activity, and abnormalities in specific clinical syndromes. The metabolism and structure-function relationships of parathyroid hormone and other revealing interactions with specific receptors in target organs are also elaborated in this publication, including a basis for some understanding of the parathyroid hormone and vitamin D-'resistant states. Other topics discussed include the fundamental considerations of the physiology and biochemistry of parathyroid hormone; pathogenesis of renal osteodystrophy; and metabolic aspects of Paget's disease. This publication also covers the effects of hypercalcemia and normocalcemic disorders of mineral metabolism. This volume is beneficial to clinicians and students concerned with metabolic bone diseases.

The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. - Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research - Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information - Includes four color images throughout

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering recent advances in the field of neurobiology. Topics covered include chromosome 22 deletion syndrome and schizophrenia; characterization of proteome of human cerebrospinal fluid; hormonal pathways regulating intermale and interfemale aggression; neuronal gap junctions; effects of genes and stress on the neurobiology of depression; quantitative imaging with teh MicroPET small-animal PET tomograph; understanding myelination through studying its evolution.

Almost all branches of chemistry and material science now interface with organometallic chemistry - the study of compounds containing carbon-metal bonds. The widely acclaimed serial Advances in Organometallic Chemistry contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964. - Provides an authoritative, definitive review addressing all aspects of organometallic chemistry - Useful to researchers within this active field and is a must for every modern library of chemistry - High quality research book within this rapidly developing field

Comprised of two separate volumes, Neuroimaging provides a state-of-the-art review of a broad range of neuroimaging techniques applied to both clinical and research settings. The breadth of the methods covered is matched by the depth of description of the theoretical background. Part B covers the application of neuroimaging in both research and clinical settings for the study of anxiety disorders, dementia, depression, schizophrenia, functional somatic syndromes, stroke, and multiple sclerosis using a range of neuroimaging modalities including CT, PET, SPECT, DTI, structural MRI and fMRI. One chapter is devoted to the study of brain development using structural MRI, and one chapter to the study of pediatric neurobehavioral disorders using fMRI. One of the most exciting recent applications of neuroimaging to the area of genetics is covered, and with the theory and application of neuroreceptor imaging in psychiatry, forms the final two chapters. The two parts of Neuroimaging complement each other providing in-depth information on a broad range of routine and cutting edge techniques that is not available in any other text. This book is superbly written and beautifully illustrated by contributors working at the top of their chosen specialty. - Presents recent applications of neuroimaging to the area of genetics - Discusses the study of brain development using structural MRI - Includes chapters on the theory and application of neuroreceptor imaging in psychiatry

PET and SPECT are two of today's most important medical-imaging methods, providing images that reveal subtle information about physiological processes in humans and animals. Emission Tomography: The Fundamentals of PET and SPECT explains the physics and engineering principles of these important functional-imaging methods. The technology of emission tomography is covered in detail, including historical origins, scientific and mathematical foundations, imaging systems and their components, image reconstruction and analysis, simulation techniques, and clinical and laboratory applications. The book describes the state of the art of emission tomography, including all facets of conventional SPECT and PET, as well as contemporary topics such as iterative image reconstruction, small-animal imaging, and PET/CT systems. This book is intended as a textbook and reference resource for graduate students, researchers, medical physicists, biomedical engineers, and professional engineers and physicists in the medical-imaging industry. Thorough tutorials of fundamental and advanced topics are presented by dozens of the leading researchers in PET and SPECT. SPECT has long been a mainstay of clinical imaging, and PET is now one of the world's fastest growing medical imaging techniques, owing to its dramatic contributions to cancer imaging and other applications. Emission Tomography: The Fundamentals of PET and SPECT is an essential resource for understanding the technology of SPECT and PET, the most widely used forms of molecular imaging.•Contains thorough tutorial treatments, coupled with coverage of advanced topics•Three of the four holders of the prestigious Institute of Electrical and Electronics Engineers Medical Imaging Scientist Award are chapter contributors•Include color artwork

The vast family of volatile organic compounds plays a central role in the chemistry of the Earth's atmosphere. Reactive Hydrocarbons in the Atmosphere provides comprehensive and up-to-date reviews covering all aspects of the behavior, sources, occurrence, and chemistry of these compounds. The book considers both biogenic and anthropogenic sources, plus their effects in the atmosphere at local, regional, and global scales. - Covers a major component of atmospheric chemistry and air pollution - Considers both natural background chemistry and pollution processes - Provides authoritative reviews for a wide range of audiences

Speech and Language: Advances in Basic Research and Practice, Volume 11 contains articles that discuss a wide range of topics on speech and language processes and pathologies. This volume is comprised of six contributions on a wide variety of topics on speech and language. The book begins with an examination of approaches to aphasia diagnostics from both a medical and nonmedical perspective. Subsequent chapters cover topics on acoustic-phonetic descriptions of speech production in speakers with cleft palate and other velopharyngeal disorders; the role of infant vocalizations as they relate to subsequent speech and language development; pitch phenomena and applications in electrolarynx speech; and practical applications of neuroanatomy. The final chapter presents the employment of studies of temporal coordination to understand the development of motor control in speech and to provide a basis for testing theories on the development of speech as a motor skill. Linguists, speech pathologists, and researchers on language development will find the book very insightful and informative.

Advances in Lipid Research, Volume 24 provides information pertinent to the fundamental aspects of skin lipids. This book discusses the importance of epidermal lipids for cutaneous barrier function. Organized into 11 chapters, this volume begins with an overview of the biochemical, metabolic, and structural aspects of the role of lipids in permeability barrier formation and maintenance. This text then examines the lipid biophysics of the intercellular lipid domains in the stratum corneum, and the regulation of percutaneous absorption by these domains. Other chapters consider the lipid content and metabolism of cultured keratinocytes, which are grown under standard conditions and in various in vitro systems that attempt to produce an epidermal equivalent. This book discusses as well the important field of lipid signaling mechanisms in the epidermis. The final chapter deals with the clinical, pathophysiological, and therapeutic applications of vitamin D. This book is a valuable resource for chemist, cytochemists, and clinicians.

Advances in Inorganic Chemistry and Radiochemistry

Air Pollution, Second Edition, Volume III: Sources of Air Pollution and Their Control discusses the cause, effect, transport, measurement, and control of air pollution. The volume tackles the emissions to the atmosphere from the principal air pollution sources; the control techniques and equipment used to minimize these emissions; the applicable laws, regulations, and standards; and the administrative and organizational procedures used to administer these laws, regulations, and standards. Engineers, physicians, meteorologists, lawyers, economists, sociologists, agronomists, toxicologists, and public administrators will find the book a valuable reference material.

A fundamental understanding of polymers has evolved in recent years concurrent with advances in analytical instrumentation. The theories and methodologies developed for the galacturonan biopolymers (collectively called pectins) have seldom been discoursed comprehensively in the context of the new knowledge. This text explains the scientific and technical basis of many of the practices followed in processing and preparing foods fabricated with or containing pectin. The material is presented in a very readable fashion for those with limited technical training. - Structural analysis - Commercial extractions methods - Pectin formulations and tropical fruit analysis - Molecular mechanisms of gelatin - Enzymology - Polymer comformation techniques - Analytical methods of polymer analysis

This volume and its companion Nonhuman Primates in Biomedical Research: Biology and Management represent the most comprehensive publications of their type on nonhuman primates. This volume addresses the diseases of nonhuman primates with an emphasis on the etiological factors, clinical signs, diagnostic pathology, therapy, and management. Its companion volume serves as a general reference for those who provide care for these animals and for those who use them in biomedical research.

Nonhuman Primates in Biomedical Research: Biology and Management represents the most comprehensive publication of its type on nonhuman primates. It also provides basic information on the biology and management of primates for anyone responsible for the care and use of these animals. A related book on primate diseases will be published in 1996. - Stresses the following major topics: - Biology and medical management - Reproductive physiology and breeding - Nutrition - Biohazards

Metabolic Bone Disease, Volume I covers the approach to a variety of disorders of mineral metabolism. The book discusses bone metabolism and calcium regulation; kidney function in calcium and phosphate metabolism; as well as the role of alkaline phosphatase in metabolic bone disorders. The text also describes the diagnostic value of bone biopsies; the etiology, clinical aspects, therapy, and the main syndromes of vitamin D deficiency, rickets, and osteomalacia; and the pathogenesis and therapy of osteoporosis. The pathogenesis and treatment of nephrolothiasis are also encompassed. Orthopedic doctors, physicians, endocrinologists, and people involved in the research of metabolic bone diseases will find the book invaluable.

Advances in Organometallic Chemistry

Biochemical Actions of Hormones, Volume IX is an 11-chapter text that provides the developments in the theoretical and experimental understanding of hormonal actions and regulation. After presenting an overview of research on peptide and steroid hormones, this volume goes on exploring the lipotropins and their active degradation products, as well as the adenylate cyclase enzyme regulation by adrenergic receptors. These topics are followed by discussions on the potassium ion conductance in the pancreatic beta cell; the concept of the insulin sensitive chemoreceptor of the central nervous system; the estrogen-induced growth factors and their role in tumor cell growth; and the nuclear acceptors for the avian progesterone receptor. Other chapters consider the structural aspects of steroid hormones and their receptors, with an emphasis on the importance of pyridoxal phosphate research studies on a better understanding of the steroid receptors function. This book also looks into an affinity label for glucocorticoid receptors and the development of a polyclonal antibody for this receptor. The concluding chapter emphasizes the regulation of the steroid sulfotransferases. This volume will be of great value to biologists, biochemists, and researchers who are interested in the biochemical aspects of hormones.

Fossil hydrocarbons form a continuous series whose'heavy'members--heavy oils, bitumens, oil shale kerogens, and coal--are important sources of conventional lighter fuels. These hydrocarbons are much more abundant and easier to extract than natural gas and oil. This book discusses the origins and compositions of fossil hydrocarbons and shows how the'heavies'can be chemically transformed into environmentally clean gas, liquid transportation fuels, and an almost unlimited range of petrochemicals.Dr. Berkowitz explodes the entrenched dichotomy between'petroleum hydrocarbons'and coal that has shaped popular perceptions of energy, showing that it is feasible to develop new technologies that capitalize on the availability of'synthetic'natural gas and light oils.Fossil Hydrocarbons: Chemistry and Technology is a comprehensive treatment of fossil hydrocarbons, covering the source materials, biosources, metamorphic histories, geochemistry, classification, and molecular structure. It discusses the use of fossil hydrocarbons as a viable energy source in our future, detailing the preparation, processing and conversion technologies, as well as discussing the environmental issues that arise from production, processing, and use of various fossil hydrocarbons. - Approaches various fossil hydrocarbons as chemically related entities, thus dispelling the unwarranted distinctions between crude oils and coal - Explains how heavy fossil hydrocarbons can be processed by much the same methods as crude oils for good economic and environmental purpose - Illustrates how bitumens, oil shales, and coals are convertible into synthetic natural gas and oils - Shows a path for reasonable energy self-sufficiency, through conversion of heavy hydrocarbons into synthetic natural gas and oils - Augments each chapter with end-of-chapter notes and a detailed bibliography - Provides more than 200 useful tables, schematics, and figures