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The remediation of contaminated soils is a great challenge for global environmental sciences and engineering. The landfill was a kind of infrastructure to deal with waste from different sources while it would also cause the threat to groundwater. Cut-off walls and pumping wells were usually applied in the landfill to prevent the spread of pollutants to wider areas. However, the combination of using both of methods was rarely analyzed, especially using field data for calibrating and fitting groundwater flow and pollutant transport. 7 monitoring wells were arranged in the study area to survey the subsurface seepage. The pollution monitoring was carried out for a period of 50 days, covering 31 types of inorganic and organic pollutants. The concentration of 2,4,6-trichlorophenol (TCP) was 556.7 times greater than the standard concentration. A coupled numerical model of groundwater flow and pollutant transport was developed to assess the effectiveness of various control methods. Three options were tested, including the implementation of a single cut-off wall as well as a combination of a cut-off wall and a pumping well, for preventing the discharge of pollutants from landfills. The combination of a cut-off wall and a pumping well is the best strategy for removal of TCP. The combination approaches lead to a reduction of pollution plumes by a factor of 11 compared to the case without pollution control measures. The research findings may provide a basis and reference for the application of cutoff walls and pumping well in landfill sites or contaminated groundwater., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Objective: Though metastasis-associated protein 1 (MTA1) is widely overexpressed in human cancers and is associated with advanced clinicopathological characteristics and survival in related diseases, the association between MTA1 and endometrial cancer (EC) is little known and needs to be studied., Methods: Western blot and immunohistochemistry were used to analyze protein expression level of cells and tissues, while real-time PCR was used for RNA detection. Bioinformatics tool analysis revealed the relationship between MTA1 and clinicopathological characteristics and survival. CCK-8 assay, colony-formation assay, cell scratch assay, and Transwell assay were performed to determine cell proliferation, migration and invasion abilities, respectively., Results: The expression level of MTA1 was significantly higher in human EC tissues than in normal endometrium. MTA1 expression was correlated positively with lymph nodes metastasis and poor survival rate in EC. Experimentally overexpressed MTA1 could promote cell proliferation, migration and invasion abilities of EC cell lines Ishikawa, HEC-1B, and RL-952, while reduction of MTA1 inhibited these cell biological behaviors. Moreover, MTA1 could also reverse the negative effect of miR-30c, a direct modulator of MTA1, on EC cells. Our research also revealed that overexpression of MTA1 contributed to EC tumor growth, while knockdown of MTA1 resulted in tumor growth inhibition. Additionally, the phosphorylation levels of mTOR (S2448) and 4E-BP1 (T37/46) changed significantly along with AKT (T308) under regulation of MTA1, both in vivo and vitro., Conclusion: Our results showed that MTA1, as a downstream target of miR-30c, might promote EC progression via AKT/mTOR/4E-BP1 pathway, which indicated the potential therapy target of MTA1 in EC., (Copyright © 2019. Published by Elsevier Inc.)