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Epigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic control of cell signaling in cancer stem cells, Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications, Epigenetic regulation in pancreatic cancer, Epigenome Editing in Cancer: Advances and Challenges for Potential Therapeutic Options, Inhibition of epigenetic mechanisms in cancer, and Epigenetics as a determinant of radiation response in cancer. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike

The second edition of The Lateralized Brain provides for readers a volume detailing the functional and structural differences between the left and right hemispheres of the brain, highlighting how the widespread use of modern neuroimaging techniques such as fMRI and DTI have completely changed the way hemispheric asymmetries are currently investigated. In this new edition, all chapters have been updated with recent advances in the field, and a new chapter on hemispheric asymmetries in development and aging has been integrated. Also featured is a new, larger section on laterality in social behavior, alongside a comprehensive overview about key topics in laterality research, including its history, evolutionary perspectives, brain structure, and the role of the corpus callosum. Chapters cover functional hemispheric asymmetries in language processing, motor behavior, spatial attention, self- and face-perception, emotion processing, and social behavior. Additional topics include the ontogenesis of hemispheric asymmetries and their development over the life span, as well as sex differences and associations with clinical syndromes. This volume can be used by anyone working on hemispheric biology or in courses on hemispheric asymmetries. - Provides a comprehensive overview about key topics in laterality research, including its history, evolutionary perspectives, the corpus callosum, and brain structure - Includes references to key articles, books, protocols, and online resources for additional, detailed study - Discusses classic studies that helped define the field of laterality research and presents introductory short stories (e.g. famous classic clinical cases in laterality research) as a starting point for each chapter - Covers key concepts and methods in separate call-out boxes for quick overview - Newly integrates a chapter on laterality in social behavior, as well as various smaller new sections covering recent advances in the field

Advances in Motivation Science, Volume Eleven, the latest release in the Motivation Science series, contains interesting articles that cover topics such as An Ecology of Meaning: An Integrative Framework for Understanding Human Motivations, Beer AMS Quest for Self Knowledge, Boundary conditions of the rational model Finding the limits of rationality, Growth goals: A review of the construct Predictors, Consequences, and Intervention, Pragmatic Prospection Theory, Research, and Practice, and The Quest for Self-Knowledge What Do We Want to Know (and not Know) About Ourselves. - Presents new research in the field of motivation science and research - Provides a timely overview of important research programs conducted by the most respected scholars in psychology - Gives special attention to directions for future research

HIV-Associated Neurocognitive Disorders: Molecular and Cellular Mechanisms and Clinical Manifestations is a comprehensive volume on the field of HIV-Associated Neurocognitive Disorders (HAND) as well as its associated comorbidities. Covering clinical manifestations as well as molecular and cellular mechanisms, this book discusses available macaque and rodent animal models of HAND, epigenetic regulation, and signaling pathways underlying symptoms. Chapters also cover prevention and therapeutic strategies, as well as diagnosis and biomarkers associated with disease outcomes. This volume is appropriate for basic research and clinical investigators working in the area of HIV-1 infection. - Provides an in-depth exploration of the clinical manifestations of HAND and its comorbidities - Includes detailed assessments of the molecular and cellular mechanisms underlying HAND symptoms - Examines animal models for studying HAND, including macaque and rodent models - Presents insights into epigenetic regulation and signaling pathways implicated in HAND - Covers prevention, therapeutic strategies, and diagnostic approaches

This volume provides a comprehensive and in-depth exploration of the SARS-CoV-2 virus and its impact on human health. Written by a team of expert contributors, the book covers various aspects of the virus, including its structure, life cycle, and genomic replication. It delves into the epidemiology of COVID-19, comparing it with other related coronaviruses and discussing the concept of herd immunity. The structural biology of SARS-CoV-2 is examined, with a focus on techniques such as electron microscopy and cryo-electron tomography. The book also explores the biology of SARS-CoV-2 variants and their immune evasion strategies. Furthermore, it delves into the pathogenesis of COVID-19, examining its multiorgan manifestations and the long-term effects of the disease. The innate and adaptive immune responses to SARS-CoV-2 are discussed in detail, along with the role of B cells and T cells in the immune response. The volume concludes with a look at future insights and potential developments in the field. Accompanied by illustrative diagrams and visuals, this volume would aid in grasping complex concepts, serving as a valuable resource for researchers, healthcare professionals, and anyone interested in understanding the intricate details of SARS-CoV-2 and its impact on global health. - Comprehensive coverage of various aspects of the COVID-19 pandemic, including virus structure, variants, immune responses, disease pathogenesis including its multiorgan manifestations and long COVID - Focus on in-depth analysis of innate and adaptive immune responses to SARS-CoV-2, including B cell and T cell responses, discussing the recognition and activation mechanisms, antibody production, immunological memory as well as the role of spike proteins in immunological regulation - Richly illustrated with informative diagrams, providing visual aids to enhance understanding of complex concepts and structures related to COVID-19

Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures.Comprehensive coverage of the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decadeIntroduces the most recent imaging technologies to characterize factors, including aortic geometry, mechanical properties of aortic tissues, and cellular activity in the vessel wallSynthesizes advances in vascular biomechanics, medical imaging, and computational modeling of finite element fluid and solid models

Quantum Sensing at the Interface of Nanotechnology Integrated Microfluidics provides broad multidisciplinary coverage of innovative quantum sensing technologies suitable to industries in the engineering, biomedical, healthcare and environmental sectors. Sections discuss emerging quantum sensing and with an introduction to microfluidic devices, smart sensors, the role of nanotechnology, smart sensing, and the role of quantum technology and artificial intelligence for nano-enabled microfluidics. Sensing technologies and nano-enabled microfluidics and their biomedical and industrial applications are explored. This will be a useful resource for those in research and industry interested in biotechnology, nanotechnology, sensing technology and their applications in multidisciplinary fields. - Provides an introduction to the types of microfluidic devices, smart sensors, and the role of nanotechnology - Covers smart sensing for multidisciplinary sectors - Explores the challenges and prospects of nano-microfluidics systems

Epigenetic Regulation of Cancer, Part C, Volume 389 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic biomarkers in breast cancer, Contribution of epigenetics to virus-driven cancer, Cancer metabolism and epigenetics, Technologies for epigenome editing, Epigenetics and cancer stemness, Epigenetic modifications in obesity-associated cancers, Epigenetics in cf microRNA in blood of solid tumors, Integrative analysis of transcriptome, chromatin accessibility, cell surface antigen in single cell level for AML, and more.Additional chapters cover Epigenetics in lung cancer, Gene Regulatory Mechanisms underlying therapy resistance in Cancer, Role of miRNAs as epigenetic regulators of immune checkpoints in cancer immunity, Epigenetic contributions to Acute myeloid leukemia (AML), Contribution of epigenetics to chemoresistance, Epigenetic contribution to the relationship between obesity and cancer, and Epigenetic regulation in ovarian cancer. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike

Applied Biotechnology Strategies to Combat Plant Abiotic Stress investigates the causal molecular factors underlying the respective mechanisms orchestrated by plants to help alleviate abiotic stress in which Although knowledge of abiotic stresses in crop plants and high throughput tools and biotechnologies is avaiable, in this book, a systematic effort has been made for integrating omics interventions across major sorts of abiotic stresses with special emphasis to major food crops infused with detailed mechanistic understanding, which would furthermore help contribute in dissecting the interdisciplinary areas of omics-driven plant abiotic stress biology in a much better manner. In 32 chapters Applied Biotechnology Strategies to Combat Plant Abiotic Stress focuses on the integration of multi-OMICS biotechnologies in deciphering molecular intricacies of plant abiotic stress namely drought, salt, cold, heat, heavy metals, in major C3 and C4 food crops. Together with this, the book provides updated knowledge of common and unique set of molecular intricacies playing a vital role in coping up severe abiotic stresses in plants deploying multi-OMICS approaches This book is a valuable resource for early researchers, senior academicians, and scientists in the field of biotechnology, biochemistry, molecular biology, researchers in agriculture and, crops for human foods, and all those who wish to broaden their knowledge in the allied field. - Describes biotechnological strategies to combat plant abiotic stress - Covers the latest evidence based multipronged approaches in understanding omics perspective of stress tolerance - Focuses on the integration of multi-OMICS technologies in deciphering molecular intricacies of plant abiotic stress

The Psychology and Neuroscience of Impulsivity is the first book to provide a comprehensive overview of impulsivity and related psychological and neural substrates. The book is divided into four sections, the first section, will provide the readers with a general overview of impulsivity, neural and cognitive substrates of impulsive behaviors, and the relationship between impulsivity and risk-taking behaviors. The second section discusses the links between impulsivity and erroneous behaviors, such as anger and aggressive behaviors and interpersonal violence. The third section reviews how impulsive behaviors are key features of several clinical disorders, such as pathological gambling, drug abuse, and antisocial personality disorder. The last section, presents possible treatment options for impulsivity, including a number case studies. - Reviews links between impulsivity to anger and aggressive behaviors - Presents treatment options for impulsivity using mindfulness techniques - Includes psychological and neural substrates of impulsivity within each chapter

Bioactive Microbial Metabolites: Scope and Challenges not only focuses on the identification, separation and purification of bioactive metabolites, the book also provides an understanding of the metabolic pathways for bioactive metabolites production that play an important role in modern healthcare as frontline treatments for many diseases. This is a valuable reference for research students, academicians and scientists in environmental microbiology and biotechnology, and for industry personnel related to microbiology/ biotechnology. The science discussed herein plays an important role in expanding the market of antibiotics, food and agriculture but also offers eco-friendly, safer and profitable solutions to respective industries. - Focuses on the identification and structure elucidation of novel microbial metabolites - Uncovers extended functions of microbial metabolites - Provides understanding of metabolic pathways for bioactive metabolites production by using several illustrations, figures and tables so that the readers can easily grasp key concepts

While there is a nearly universal agreement that drinking tea can benefit health, information on the benefits or adverse effects of drinking tea is scattered, leaving definitive answers difficult to ascertain. Tea in Health and Disease Prevention, Second Edition, once again addresses this problem, bringing together all the latest and most relevant information on tea and its health effects into one comprehensive resource. This book covers compounds in black, green, and white teas and explores their health implications, first more generally, then in terms of specific organ systems and diseases. With over 75% brand new content, this fully reorganized, updated edition covers a wider range of tea varieties and beneficial compounds found in tea, such as epigallocatechin gallate and antioxidants.Tea in Health and Disease Prevention, Second Edition, is an organized, efficient resource that will help readers find quick answers to questions and will help inspire further studies for those interested in tea research. This is a must-have reference for researchers in food science and nutrition, as well as nutritionists and dieticians. - Covers and compares features, benefits, and potential negative effects of the most important types of tea, including green, black, and white - Identifies therapeutic benefits of teas for new product development - Offers a'one stop shop'for research in this area, compiling both foundational and cutting-edge topics into one resource - Includes a dictionary of key terms, other health effects of tea or extracts, and a summary point section within each chapter for a quick reference

COVID-19 in Alzheimer's Disease and Dementia crucially summarizes the current status of the coronavirus in patients suffering from these conditions, describing why they are a common cause of morbidity among those with COVID-19. The first section includes chapters that provide a general description of COVID-19, including SARS-CoV-2 structure, function, and biology, and its impact on the elderly with chronic conditions include hypertension, diabetes, obesity, kidney disease, respiratory illnesses, and infectious diseases. Also discussed are effects of the virus on the immune system. The second section shifts to the impact of COVID-19 on those with dementia or Alzheimer's disease, with special emphasis on age, gender, ethnic background, and lifestyle. Bringing this focus on neurodegenerative disease in one comprehensive resource, this volume is an essential reference for neuroscientists, clinicians, biomedical scientists, and all others working or interested in the field. - Discusses Alzheimer's disease and dementia as morbidities for COVID-19 - Describes SARS-CoV-2 structure, function, and biology - Examines impact on elderly with chronic conditions including hypertension, diabetes, obesity, kidney disease, respiratory illnesses, and infectious diseases - Covers the effect of race, gender, and sex as additional risk factors

Sustainable Plant Nutrition: Molecular Interventions and Advancements for Crop Improvement explores the significant opportunities for sustainable, eco-friendly approaches in plant nutrition and agricultural crop production. The book highlights the various prospects involved in optimizing plant nutrient uptake agriculture and includes chapters representing diverse areas dealing with biotechnology, nanotechnology, molecular biology, proteomics, genomics and metabolomics. This book is an ideal resource for those seeking to ensure a sustainable plant production future. While plants have evolved a set of elaborate mechanisms to cope with nutrient limitations, the traditional supplementation by the application of fertilizers to plant productivity may then lead to overfertilization which can actually reduce plant growth and have adverse effects on the environment. To tackle these issues, a detailed understanding of the responses of plants to nutrients and nutrient deficiency at the physiological, metabolic, transcriptome and epigenetic level is essential. - Illustrates the central role of sustainable plant nutrition to address current and future challenges - Presents global insights and research ranging from signaling to sensing and translational research - Provides a forward-looking perspective for future plans of action

Translational Autoimmunity: Advances in Autoimmune Rheumatic Diseases, Volume Six addresses autoimmune diseases classified under the category of rheumatic diseases. Rheumatic diseases are heterogeneous groups of disorders in which inflammation affects not only joints, but also tendons, ligaments and bones. This updated release focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, osteoarthritis and Sjogren's syndrome, and will be of interest to researchers, students and clinicians interested in autoimmune diseases, especially rheumatic diseases. From an introduction to rheumatic diseases to diagnostic laboratory tests, and from the microbiota-immunity to cell-based therapies, the bench to bedside approach to rheumatic diseases is the main subject of discussion in this comprehensive resource. - Gives an introduction on rheumatic diseases, from bench to bedside - Describes diagnostic laboratory tests in rheumatic diseases - Meets the needs of basic scientists, clinicians and translational scientists and industry partners - Focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases

Advances in Heterocyclic Chemistry, Volume 139, the latest release in this definitive series on the field of heterocyclic chemistry, combines descriptive synthetic chemistry and mechanistic insights to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. Topics in this new release include Application of the Fischer indole synthesis in medicinal chemistry, Oxindole Synthesis via C-H Activation Methods, Ring-Closing Metathesis in the Synthesis of Fused Indole Structures, Synthesis of fuller heterocycles, The Literature of Heterocyclic Chemistry, Part XX, 2020, and Heterocyclic Zwitterions Based on Coupled Polymethines. - Presents what is considered to be the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds

Angiotensin: From the Kidney to Coronavirus, a new volume in the Molecular Mediators in Health and Disease series, presents the communication role of the hormone in both health and disease states. Beyond the most common conditions, the book also explores the role of Angiotensin in infectious diseases, like COVID-19. Sections provide background to its discovery and role in homeostasis, focus on molecular biology aspects, including genetics and measurements of its associated proteins, describe the specific actions of angiotensin in normal physiology with different organ systems, survey different classes of drugs that act on the Renin-angiotensin-aldosterone system, cover non-angiotensin II peptides, and more. The final part of the book is dedicated to angiotensin's role in disease states, making this the ideal reference for researchers in life sciences interested in understanding the physiological role of Angiotensin in a complete fashion. Research physicians will also benefit from the book's complete coverage of organ systems and diseases where Angiotensin plays a key role. - Covers the traditional disorders related to Angiotensin and new findings like its role in infectious diseases like COVID-19 - Offers an overview of all important aspects of angiotensin, from discovery to clinical application, from physical and chemical properties to the physiological/cellular interaction - Expands on the role of angiotensin beyond the individual system the researcher is focusing, providing a comprehensive coverage of the additional effects at cell, tissue, organ, and system levels

Cancer glycobiology is a blazing hot area of cancer research with aberrant post-translational glycosylations on lipids and proteins considered critical for cancer development and metastasis. The NIH/NCI Alliance of Glycobiologists for Cancer Research is a consortium of (10) tumor glycobiology laboratories funded to investigate how cancer-associated glycans (CAG) impact the development and metastasis of cancer. The hope of this momentous effort is to discover CAGs for use as novel biomarkers to detect early-stage cancer or its aggressive behavior or, alternatively, as novel molecular targets with the promise of a curative approach to cancer therapy. The mission of the'Alliance'is to study structure and function of CAGs in cancer development and to provide clinically useful biomarkers for detecting cancer early or the potential of metastasis. This charge has stimulated extensive collaborations across US and International institutions to accelerate discovery of glycan-based biomarkers to the forefront of NCI's efforts to diagnose early-stage cancer and provide curative anti-cancer therapies. The main goals of these research efforts are: 1. To identify and study how cancer-associated glycans functionally impact cancer growth and metastasis2. To identify cancer-associated glycans that can serve as biomarkers for the detection or progression of cancer3. To develop cancer-associated glycans as novel therapeutic targets for the treatment and cure of cancer This volume consists of (9) chapters, one from each funded laboratory, that reviews new methods and mechanisms highlighting glycoconjugates and their roles as cancer biomarkers and/or anti-cancer therapeutic targets. - Historical and Novel Glycobiological Biomarkers of Cancer and Disease Progression - Novel Glycobiological Mechanisms Driving Cancer Progression - Novel Methods for Discovering Glycobiological Biomarkers of Cancer

Epigenetic Regulation of Cancer in Response to Chemotherapy, Volume 158 of the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting chapters on timely topics, including Epigenetically Programmed Resistance to Chemotherapy and Promotion of Immune Evasion in Cancer, A Role for the Epigenome in Cancer Cell Drug Tolerance, Histone Methylation and X Chromosomal Genes in Metastasis of Breast Cancer, Targeting Epigenetic Regulation Using Small Molecule Inhibitors, Histone Deacetylase Inhibitors as Sanguine Epigenetic Therapeutics against Pugnacious Lung Cancer, From ecology to oncology: To understand cancer stem cell dormancy, ask a Brine shrimp (Artemia), and more. Additional chapters cover Predictive Models of Chemoresistance Generated by Crunching the Public Drug Screen, Epigenomic and Genomic Profiling Datasets via Regression-, Machine Learning, and Knowledge-Based Methods, Probing on the Mechanisms of lncRNAs on Cancer Drug Resistance, Drug Tolerant Persister Cells in Cancer: Current Knowledge and Therapeutic Perspectives, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Cancer Research series - Includes the latest information on the Epigenetic Regulation of Cancer in Response to Chemotherapy

Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering. - Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies - Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, thus demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs - Provides a fully updated resource on new topics, including the epitranscriptome, oncohistones, single cell analysis, epigenetic priming, CRISPR therapy, CAR-T therapy, and epigenetics and pollution - Features chapter contributions from leading experts in the field

Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics. Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure. Provides a comprehensive update on the role of sinusoidal cells in acute and chronic liver diseasesCovers our current understanding of the role of sinusoidal cells as therapeutic targets to improve liver diseasesPresents the latest research in the development of novel biomarkers of liver diseases that derive from sinusoidal cells

Molecular Medical Microbiology, Third Edition presents the latest release in what is considered to be the first book to synthesize new developments in both molecular and clinical research. The molecular age has brought about dramatic changes in medical microbiology, along with great leaps in our understanding of the mechanisms of infectious disease. This third edition is completely updated, reviewed and expanded, providing a timely and helpful update for microbiologists, students and clinicians in the era of increasing use of molecular techniques, changing epidemiology and prevalence, and increasing resistance of many pathogenic bacteria. Written by experts in the field, chapters include cutting-edge information and clinical overviews for each major bacterial group, along with the latest updates on vaccine development, molecular technology and diagnostic technology. - Completely updated and revised edition of this comprehensive and accessible reference on molecular medical microbiology - Includes full color presentations throughout - Delves into in-depth discussions on individual pathogenic bacteria in a system-oriented approach - Includes a clinical overview for each major bacterial group - Presents the latest information on vaccine development, molecular technology and diagnostic technology - Provides more than 100 chapters on all major groups of bacteria

Pseudokinases, Volume 667, the latest release in the Methods in Enzymology serial, highlights new advances in the field with this new volume presenting interesting chapters, including the Production and Purification of the PEAK pseudokinases for structural and functional studies, Structural biology and biophysical characterization of Tribbles pseudokinases, Detecting endogenous TRIB protein expression and its downstream signaling, Analysis of human Tribbles 2 pseudokinase, Expression, purification and examination of ligand-binding to IRAK pseudokinases, Characterization of pseudokinase ILK-mediated actin assembly, Biochemical examination of Titin pseudokinase, Approaches to study pseudokinase conformations, CRISPR editing cell lines for reconstitution studies of pseudokinase function, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology serials - Includes the latest information on Pseudokinases

Boron in Plants and Agriculture: Exploring the Physiology of Boron and Its Impact on Plant Growth highlights the various emerging techniques and applications that are currently being used in plant-boron interaction studies, and provides a direction towards implementation of programs and practices that will enable sustainable production of crops, resilient to boron stress. Boron is an important micronutrient that plays a crucial role in the growth and development of plants, however despite a significant amount of recent research, there has remained a gap in the understanding of boron update and transportation. Boron deficiency is one of the most widespread deficiencies among plant micronutrients in agriculture and it causes a wide range of symptoms including the cessation of root elongation, reduced leaf expansion and the loss of fertility, depending on the plant species and developmental stage. This book reviews and integrates the currently available information on the impact of boron on functional and adaptive features of plants from molecular, biochemical, physiological to whole plant level. It is a key resource for those working in stress physiology, stress proteins, genomics, proteomics, genetic engineering and other fields of plant physiology related to boron nutrition, including agriculture. - Highlights various emerging techniques and applications that are currently being used in plant-boron interaction studies, along with future prospects - Provides direction towards the implementation of programs and practices that will enable sustainable production of crops that are resilient to boron stress - Introduces global leaders working in the area of plant-boron interactions and shares their research findings

Advances in Heterocyclic Chemistry, Volume 138, the latest release in this definitive series on the field of heterocyclic chemistry, combines descriptive synthetic chemistry and mechanistic insights to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. Topics in this new release include The Paal Knorr reaction in Heterocyclic Chemistry, Synthesis and Applications of Heterocyclic Sulfoximines, Recent advances in the synthesis of 4H-chromen-4-ones (2012-2021), Recent Developments in the Chemistry of Heteroporphyrins and Heterocarbaporphyrins, The Chemistry of 1,4-Dihydropyrrolo[3,2-b]pyrroles, and more. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds

Sex and Gender Bias in Technology and Artificial Intelligence: Biomedicine and Healthcare Applications details the integration of sex and gender as critical factors in innovative technologies (artificial intelligence, digital medicine, natural language processing, robotics) for biomedicine and healthcare applications. By systematically reviewing existing scientific literature, a multidisciplinary group of international experts analyze diverse aspects of the complex relationship between sex and gender, health and technology, providing a perspective overview of the pressing need of an ethically-informed science. The reader is guided through the latest implementations and insights in technological areas of accelerated growth, putting forward the neglected and overlooked aspects of sex and gender in biomedical research and healthcare solutions that leverage artificial intelligence, biosensors, and personalized medicine approaches to predict and prevent disease outcomes. The reader comes away with a critical understanding of this fundamental issue for the sake of better future technologies and more effective clinical approaches. - First comprehensive title addressing the topic of sex and gender biases and artificial intelligence applications to biomedical research and healthcare - Co-published by the Women's Brain Project, a leading non-profit organization in this area - Guides the reader through important topics like the Generation of Clinical Data, Clinical Trials, Big Data Analytics, Digital Biomarkers, Natural Language Processing

Encyclopedia of Respiratory Medicine, Second Edition, Six Volume Set explores the key processes of lung diseases and their diagnosis and management. The book dissects the molecular and cellular biology, physiology and immunology that underpin normal lung function, along with the aberrations that occur in respiratory diseases, from common disorders such as asthma and COPD to rarer lung diseases such as cystic fibrosis, interstitial lung diseases and pulmonary hypertension. Written in at a time when the globe is in the grip of respiratory pandemic, lung disease has never been so prominent in the public and political conscious. This new edition will provide new researchers in respiratory medicine with a solid foundation in unfamiliar topics and will update more experienced researchers seeking to step outside their core areas of research to put their work into a broader context. - Presents a'one-stop'resource covering the entire scope of modern respiratory medicine - Brings together a truly global collaboration of some of the most authoritative voices in respiratory medicine - Provides chapters that are concise and accessible, with an authoritative introduction for non-specialists, as well as up-to-date, foundational content for those familiar with the field - Includes multimedia-rich content, including hundreds of clear and helpful illustrations that can be used as teaching aids

'Cell niches are present in several human body tissues as a dynamic microenvironment essential to modulate stem cells'behavior in health, under injury, and in regenerative processes. The interplay between stem cells and their niche is necessary for sustaining tissues. The extracellular matrix (ECM) is the crucial component of the stem cell. It defines the architectural space, physical binding to the cell membrane, and interactions with the neighborhood cells and supports physical stress. Domains with nano or micrometric sizes define the surface and topology of the ECM, mediating cell interactions and macrophage recruitment to injured sites. Over the last two decades, the integration of biomedicine with other engineering and biomaterial sciences promoted the development of nanotechnology and regenerative medicine toward mimicking the specialized stem cell niches to treat diseases with less invasive and efficient therapies. Innovative approaches in nanotechnology, such as targeting the immunological system, transporting drugs across blood–brain/BBB and blood–retinal barriers/BRB, directing active moiety to specific disease location/organs, encapsulation of multiple components, and promoting signalization and pathway-specific surfaces for cell interactions and growth, are indeed promising. On the other side, developments of biomaterial scaffolds to mimic the cell niches for interactions with stem cells in vitro or in vivo have tremendous potential. The three-dimensional printing technology offers a base for a wide array of applications, for example, developing tissue constructs, mimetic organs, organoids, and organ-on-a-chip, thus avoiding the differences between animal model species and humans. Aiming closer to the natural environments, fresh autologous products from the blood, such as platelet-rich plasma (PRP), contain platelets and leukocytes, providing growth factors, cytokines, and proteins for the resident stem cells in the stages of regeneration. PRP also provides pain relief, reducing disabilities in elderly or diseased people. This book brings thought-provoking multidisciplinary topics on the diverse aspects of basic and applied sciences. The prime focus of the compilation is to understand the challenges researchers encounter in combining nanotechnology and regenerative medicine, ultimately integrating both disciplines for the benefit of the patient and offering them a ray of hope to be cured. - Presents multi-disciplined knowledge on bench-to-bedside application of nanotechnology in regenerative medicines - Highlights the fundamentals, frontiers, limitations, and challenges faced by regenerative medicines - Exhibits synergy of biotechnology, nanomedicine, biomedicine, chemical-material engineering, pharmaceutical technology, and applied medical sciences in success of regenerative medicines

Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. - Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers - Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice - Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice - Covers case studies that highlight the practical use of genomics in the management of patients

Advances in Dietary Lipids and Human Health systematically summarizes recent research advances in dietary lipids and human health. The book proposes a strategy for the prevention of NCDs and the management of population and personal health through the rational use of dietary fat. It covers the relationship between total lipids, saturated and unsaturated fatty acids and NCDs, and other uncommon fatty acids, such as conjugated fatty acids, middle and short chain fatty acid, furan fatty acids, n-3 docosapentaenoic acid (DPA), and structured fat. Intended for nutrition researchers, dieticians, clinicians and others in academia who are focused on medicine, preventive medicine, public health and food science students, this valuable reference provides information that will assist readers in the prevention and treatment of cardiovascular disease, hypertension, metabolic disorders, diabetes, neuropsychiatric diseases, and cancer by specifically managing dietary lipids. - Offers an evidence-based, systematic review of dietary fat and fatty acids and health - Provides extensive knowledge on the relationship between type and quantity of lipid, fatty acids and NCDs - Proposes a strategy for the prevention of NCDs and the management of population and personal health through the rational use of dietary fat

Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-Oncology: From Basic Research to Advanced Study analyzes the emerging the field of cardio-oncology, reviewing recent advancements in the field, discussing how to monitor and treat cancer survivors for cardiotoxicity, and identifying potential cardiac side effects in novel cancer therapies. By adopting a translational approach, the book first comprehensively covers the basic science, mechanisms and concepts, which is followed by advanced state-of-art of cardio-oncology. Other sections cover tyrosine kinase inhibitors, Anthracyclines, and biomarkers in cardiotoxicity induced by chemotherapeutic drugs, noninvasive cardiovascular imaging techniques, radiotherapy induced cardiovascular, and more. Anti-cancer treatment is associated with serious cardiovascular adverse events, including arterial and pulmonary hypertension, supraventricular and ventricular arrhythmias, systolic and diastolic cardiac dysfunction and coronary artery disease. Progress in cancer therapy over the past decades improved long-term survival but increased cancer therapy-related cardiotoxicity. Both traditional chemotherapeutic agents and newer therapies have demonstrated profound cardiovascular toxicities. It is important to understand the mechanisms of these toxicities to establish strategies for the prevention and management of complications—arrhythmias, heart failure, and even death. - Adopts a translational approach and comprehensively covers the basic science, mechanisms and concepts of cardio-oncology - Outlines the current knowledge of biomarkers in cancer therapy-related cardiotoxicity - Provides an understanding of the mechanisms of cardiovascular toxicity of various therapies that may lead to the identification of novel targets to reduce vascular complications

Nutraceuticals: Efficacy, Safety and Toxicity, Second Edition, brings together everything that is currently known about nutraceuticals and their potential toxic effects. The book introduces readers to nutraceuticals, herbal medicines, Ayurvedic medicines, prebiotics, probiotics, adaptogens, and their uses and specific applications. This essential reference discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered. Completely revised and updated, this updated edition provides toxicologists, pharmacologists, pharmaceutical scientists, and those interested in medicinal plants and natural products with a comprehensive overview of the most effective tools upon which to evaluate the safety and toxicity of nutraceuticals, prebiotics, probiotics and alternative medicines. - Presents a completely revised and updated resource on the impact of nutraceuticals and various disease states such as diabetes and ophthalmic and dermal diseases - Grants an overview of the current state-of-the-science of nutraceuticals, their use and applications, and known adverse effects - Provides effective tools to evaluate the potential toxicity of any nutraceutical - Includes details of regulatory issues as written by international experts

Encyclopedia of Virology, Fourth Edition, Five Volume Set builds on the solid foundation laid by the previous editions, expanding its reach with new and timely topics. In five volumes, the work provides comprehensive coverage of the whole virosphere, making this a unique resource. Content explores viruses present in the environment and the pathogenic viruses of humans, animals, plants and microorganisms. Key areas and concepts concerning virus classification, structure, epidemiology, pathogenesis, diagnosis, treatment and prevention are discussed, guiding the reader through chapters that are presented at an accessible level, and include further readings for those needing more specific information. More than ever now, with the Covid19 pandemic, we are seeing the huge impact viruses have on our life and society. This encyclopedia is a must-have resource for scientists and practitioners, and a great source of information for the wider public. - Offers students and researchers a one-stop shop for information on virology not easily available elsewhere - Fills a critical gap of information in a field that has seen significant progress in recent years - Authored and edited by recognized experts in the field, with a range of different expertise, thus ensuring a high-quality standard

Measuring and Modeling Persons and Situations presents major innovations and contributions on the topic, promoting deeper integration, cross-pollination of ideas across diverse academic disciplines, and the facilitation of the development of practical applications such as matching people to jobs, understanding decision making, and predicting how a group of individuals will interact with one another. The book is organized around two overarching and interrelated themes, with the first focusing on assessing the person and the situation, covering methodological advances and techniques for inferring and measuring characteristics, and showing how they can be instantiated for measurement and predictive purposes. The book's second theme presents theoretical models, conceptualizing how factors of the person and situation can help us understand the psychological dynamics which underlie behavior, the psychological experience of fit or congruence with one's environment, and changes in personality traits over time. - Identifies technologies for measuring and predicting behavior - Infers behavior causes from personality and/or situational variables - Utilizes big data, machine learning and modeling to understand behavior - Includes mobile phone, social media and wearable tech usage analysis - Explores the stability of personality over time - Considers behavior analysis to treat maladaptive behavior

Hormones and Aging, Volume 115 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including hypothalamic aging and hormones, endocannabinoids and aging-inflammation, neuroplasticity, mood and pain, the impact of hormones and bone loss across the menopause transition, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Vitamins and Hormones series - Includes the latest information on Hormones and Aging