5 results on '"Steinbichler TB"'
Search Results
2. EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma.
- Author
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Ingruber J, Dudás J, Savic D, Schweigl G, Steinbichler TB, Greier MDC, Santer M, Carollo S, Trajanoski Z, and Riechelmann H
- Subjects
- Cadherins metabolism, Cell Line, Tumor, Cell Movement genetics, Epithelial-Mesenchymal Transition genetics, Gene Expression Regulation, Neoplastic, Humans, Snail Family Transcription Factors genetics, Snail Family Transcription Factors metabolism, Squamous Cell Carcinoma of Head and Neck genetics, Transcription Factors genetics, Transcription Factors metabolism, Tumor Microenvironment, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms genetics, Papillomavirus Infections genetics
- Abstract
Epithelial to mesenchymal transition (EMT) describes a process where epithelial tumor cells acquire mesenchymal characteristics. EMT often correlates with invasion and an increased cell migration potential by losing cellular polarity and cell-cell junctions. It is mainly induced by tumor-microenvironment factors, such as TGF-beta 1 and IL-6, which activate the increased expression of the EMT-transcription factor (TF) Slug. We previously reported the Slug/Krüppel-like factor 4 (KLF4) switch in EMT in HNSCC, and found, that in human papilloma virus (HPV)-negative HNSCC Slug gene expression was significant higher represented, than in HPV-positive HNSCC. The purpose of this study was to investigate the impact of KLF4 and Slug on the regulation of the cadherin switch and on the EMT phenotype. Gene expression of KLF4 positive correlated with E-cadherin in 71 head and neck squamous cell carcinoma (HNSCC) patient tissue samples, which we also confirmed by the investigation of the Cancer Genome Atlas database (TCGA). HPV-transcripts contributed to stabilization of KLF4 at protein level, and simultaneously upregulated E-cadherin. Furthermore, ectopic KLF4 overexpression was associated with epithelial gene expression by induction of E-cadherin, β-catenin and 70-kDa heat shock protein (HSP-70). The presence of HSP-70 ensures the membranous localization of E-cadherin, therefore, the ability of cells to form cadherin/catenin complexes and cellular linkages. In conclusion, KLF4 is a major regulator of the epithelial cadherin-adhesion in HNSCC., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
3. Cancer stem cells and their unique role in metastatic spread.
- Author
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Steinbichler TB, Savic D, Dudás J, Kvitsaridze I, Skvortsov S, Riechelmann H, and Skvortsova II
- Subjects
- Animals, Cell Plasticity, Cell Survival, Disease Progression, Disease Susceptibility, Epithelial-Mesenchymal Transition, Humans, Neoplasms etiology, Neoplastic Stem Cells pathology, Neovascularization, Pathologic genetics, Neovascularization, Pathologic metabolism, Neoplasms metabolism, Neoplasms pathology, Neoplastic Stem Cells metabolism, Tumor Microenvironment
- Abstract
Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult stem cells, especially self-renewal and differentiation, but also dormancy and cellular plasticity that allow adaption to new environmental circumstances. These abilities are ideal prerequisites for the successful establishment of metastasis. This review highlights the role of CSCs in every step of the metastatic cascade from cancer cell invasion into blood vessels, survival in the blood stream, attachment and extravasation as well as colonization of the host organ and subsequent establishment of distant macrometastasis., Competing Interests: Declaration of Competing Interest The authors indicate no potential conflicts of interest., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
4. Therapy resistance mediated by cancer stem cells.
- Author
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Steinbichler TB, Dudás J, Skvortsov S, Ganswindt U, Riechelmann H, and Skvortsova II
- Subjects
- ATP-Binding Cassette Transporters antagonists & inhibitors, ATP-Binding Cassette Transporters genetics, ATP-Binding Cassette Transporters metabolism, Chemoradiotherapy, DNA Repair genetics, Drug Resistance, Neoplasm drug effects, Gene Expression Regulation, Neoplastic drug effects, Gene Expression Regulation, Neoplastic radiation effects, Humans, Neoplasms metabolism, Neoplasms therapy, Neoplastic Stem Cells drug effects, Neoplastic Stem Cells radiation effects, Radiation Tolerance drug effects, Telmisartan therapeutic use, Drug Resistance, Neoplasm genetics, Neoplasms genetics, Neoplastic Stem Cells metabolism, Radiation Tolerance genetics
- Abstract
Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult stem cells, especially self-renewal and differentiation. The CSC model assumes that this subpopulation of cells sustains malignant growth, which suggests a hierarchical organization of tumors in which CSCs are on top and responsible for the generation of intratumoral heterogeneity. Effective tumor therapy requires the eradication of CSC as they can support regrowth of the tumor resulting in recurrence. However, eradication of CSC is difficult because they frequently are therapy resistant. Therapy resistance is mediated by the acquisition of dormancy, increased DNA repair and drug efflux capacity, decreased apoptosis as well as the interaction between CSC and their supporting microenvironment, the CSC niche. This review highlights the role of CSC in chemo- and radiotherapy resistance as well as possible ways to overcome CSC mediated therapy resistance., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
5. The role of exosomes in cancer metastasis.
- Author
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Steinbichler TB, Dudás J, Riechelmann H, and Skvortsova II
- Subjects
- Exosomes pathology, Humans, Liquid Biopsy, Neoplasm Metastasis pathology, Neoplasms pathology, Tumor Microenvironment genetics, Exosomes genetics, Neoplasm Metastasis genetics, Neoplasms genetics
- Abstract
Exosomes are small membrane vesicles with a size ranging from 40 to 100nm. They can serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a complex multistep process of cancer cell invasion, survival in blood vessels, attachment to and colonization of the host organ. Exosomes influence every step of this cascade and can be targeted by oncological treatment. This review highlights the role of exosomes in the various steps of the metastatic cascade and how exosome dependent pathways can be targeted as therapeutic approach or used for liquid biopsies., (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
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