1. The role of T helper 1-cell response in Helicobacter pylori-infection.
- Author
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Bagheri N, Salimzadeh L, and Shirzad H
- Subjects
- Gastric Mucosa microbiology, Gastric Mucosa pathology, Gastritis microbiology, Gastritis pathology, Helicobacter Infections microbiology, Helicobacter Infections pathology, Helicobacter pylori pathogenicity, Humans, Interferon-gamma immunology, Peptic Ulcer microbiology, Stomach Neoplasms microbiology, T-Lymphocytes, Regulatory immunology, Th17 Cells immunology, Gastric Mucosa immunology, Gastritis immunology, Helicobacter Infections immunology, Helicobacter pylori immunology, Host-Pathogen Interactions immunology, Th1 Cells immunology
- Abstract
Helicobacter pylori (H. pylori) is a human pathogen affecting over 50% of the world population. This pathogen is usually associated with chronic inflammation of the gastric mucosa that can lead to peptic ulcer disease (PUD) and gastric cancer (GC), especially in susceptible individuals. These outcomes have been attributed to the interaction of several factors, including host genetic susceptibility, local innate and adaptive immune responses, virulence factors of H. pylori, and environmental factors. T helper (Th) cell subsets and their signature cytokines especially IFN-γ, contribute to anti-bacterial response, but at the mean time sustaining chronic inflammatory responses in the site of infection. It has been acknowledged that H. pylori-infection results in a Th1-dominant response and that inflammation of the gastric mucosa depends mainly on Th1 cell responses. But, the mechanism of the role of Th1 cell responses in H. pylori-infection has not yet been clearly explained. In this review, we will focus on the role of Th1 involved in H. pylori-infection, its interaction with Th17/Treg cells and its association with the clinical consequences of the infection., (Copyright © 2018. Published by Elsevier Ltd.)
- Published
- 2018
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