1. Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space.
- Author
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Schmolka N, Wencker M, Hayday AC, and Silva-Santos B
- Subjects
- Animals, Humans, Receptors, Antigen, T-Cell, gamma-delta metabolism, Thymus Gland cytology, Cell Differentiation, Epigenesis, Genetic, T-Lymphocytes cytology, T-Lymphocytes immunology, Transcription, Genetic
- Abstract
γδ T cells are major providers of the pro-inflammatory cytokines interferon-γ (IFNγ) and interleukin-17 (IL-17) in protective or pathogenic immune responses. Notably, murine γδ T cells commit to either IFNγ or IL-17 production during development in the thymus, before any subsequent activation in the periphery. Here we discuss the molecular networks that underlie thymic γδ T cell differentiation, as well as the mechanisms that sustain or modify their functional properties in the periphery. We concentrate on recent findings on lymphoid and tissue-resident γδ T cell subpopulations, with an emphasis on genome-wide studies and their added value to elucidate the regulation of γδ T cell differentiation at the transcriptional and epigenetic (chromatin) levels., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2015
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