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Comprehensive Chirality, Second Edition is the definitive ten-volume reference, offering a thorough exploration of chiral research and application. This extensively updated edition features 121 new chapters and 70 revised ones, focusing on the latest advancements in chiral research across synthesis, catalysis, analytical chemistry, and bioactive compound synthesis. Edited by a world-class editorial board, with contributions from leading experts, Comprehensive Chirality, Second Edition bridges theoretical principles with practical applications, making it an invaluable resource for advanced students, researchers, and professionals. Key highlights include:- Innovative Reactions and Methods: advanced diastereo- and enantioselective techniques for controlling stereogenic centers in complex natural products and pharmaceuticals.- Chiral Auxiliaries and Modern Reagents: transformative uses of chiral auxiliaries and cutting-edge reagents such as hypervalent iodide.- Catalytic Methodologies: comprehensive coverage of C-C bond formation, emphasizing transition metals, biocatalysis, and multicatalysis.- Asymmetric Photochemistry: light-induced asymmetric transformations.- Olefin Functionalization and Cycloaddition: asymmetric oxidation and reduction methods.- Biocatalysis and Enzyme Engineering: in-depth analysis of enzyme design and engineering as powerful synthesis catalysts.- Industrial Applications: practical insights into asymmetric synthesis for industrial applications, illustrated through recent case studies.- Spectroscopic Techniques: updated spectroscopic methods for separating and analyzing enantiomers. - Unites different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts - Includes different areas of research and deep foundational reviews - Helps users apply context to diverse journal literature, aiding them in identifying areas for further research and/or for solving problems - Serves as a valuable, critical tool for instructors, practicing experimentalists, and students of the field, as well as those curious to gain appreciation of the chirality landscape and its vast expanse

Pseudokinases, Volume 667, the latest release in the Methods in Enzymology serial, highlights new advances in the field with this new volume presenting interesting chapters, including the Production and Purification of the PEAK pseudokinases for structural and functional studies, Structural biology and biophysical characterization of Tribbles pseudokinases, Detecting endogenous TRIB protein expression and its downstream signaling, Analysis of human Tribbles 2 pseudokinase, Expression, purification and examination of ligand-binding to IRAK pseudokinases, Characterization of pseudokinase ILK-mediated actin assembly, Biochemical examination of Titin pseudokinase, Approaches to study pseudokinase conformations, CRISPR editing cell lines for reconstitution studies of pseudokinase function, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology serials - Includes the latest information on Pseudokinases

Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. A full Solutions Manual is also available online for qualified instructors, to support teaching. Winner, 2018 Textbook Excellence Award (Texty) from the Textbook and Academic Authors Association Fully revised and updated throughout, and organized into 19 chapters for a more cogent and versatile presentation of concepts Includes reaction examples taken from literature research reported between 2010-2015 Features new full-color art and new chapter content on process chemistry and green organic chemistry Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Solutions Manual for qualified course instructors

Although interesting in its own right, due to the ever-increasing use of satellites for communication and navigation, weather in the ionosphere is of great concern. Every such system uses trans-ionospheric propagation of radio waves, waves which must traverse the commonly turbulent ionosphere. Understanding this turbulence and predicting it are one of the major goals of the National Space Weather program. Acquiring such a prediction capability will rest on understanding the very topics of this book, the plasma physics and electrodynamics of the system. - Fully updated to reflect advances in the field in the 20 years since the first edition published - Explores the buffeting of the ionosphere from above by the sun and from below by the lower atmosphere - Unique text appropriate both as a reference and for coursework

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties.• Serves as an essential working handbook aimed at scientists and students in medicinal chemistry• Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies • Discusses improvements in pharmacokinetics from a practical chemist's standpoint

The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered''the Bible''by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a''first-read''or''bedside book''for readers who are embarking on a career in medicinal chemistry.NEW TO THIS EDITION: • Focus on chemoinformatics and drug discovery • Enhanced pedagogical features• New chapters including: - Drug absorption and transport - Multi-target drugs• Updates on hot new areas: NEW! Drug discovery and the latest techniques NEW! How potential drugs can move through the drug discovery/ development phases more quickly NEW! Chemoinformatics

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals market. - Critical reviews of the previous year's literature in many topics of interest to medicinal chemists - Highlights major developments in medicinal chemistry - Includes a comprehensive set of cumulative indices to easily locate topics in all published volumes

Almost all branches of chemistry and material science now interface with organometallic chemistry - the study of compounds containing carbon-metal bonds. The widely acclaimed serial Advances in Organometallic Chemistry contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964. - Provides an authoritative, definitive review addressing all aspects of organometallic chemistry - Useful to researchers within this active field and is a must for every modern library of chemistry - High quality research book within this rapidly developing field

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. - One work that can be consulted for all aspects of anticancer drug development - Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts - A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death - Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products - Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques - Hundreds of references that allow the reader to access relevant scientific and medical literature - Clear illustrations, some in color, that provide both understanding of the field and material for teaching

The objective of the serial is to present considered reviews on the quantitative study of organic compounds and their behavior--physical organic chemistry in its broadest sense--in a manner accessible to a general readership.

This is a well-established series for the publication of authoritative reviews on the methods and results of the application of quantitative physical and mathematical methods to organic chemistry. The authors are acknowledged experts in their particular fields, and the contributions give the reader an up-to-date account of different aspects of physical organic chemistry. In the pursuit of challenging problems of organic chemistry, the series encourages forward-looking reviews on a variety of topics, not all of which may as yet conform to conventional notions of the scope of the field.

The all-new Fourth Edition of Pathology of Domestic Animals comprehensively covers the biology and pathology of diseases of domestic animals on a systemic basic. Updated and expanded to reflect the current knowledge of the study of domestic animal diseases, this three-volume set appeals to veterinarians, veterinary students, trainee veterinary pathologists learning the scope of their field, and practicing pathologists confronted with diagnostic problems. - All material completely updated and expanded to reflect the current knowledge of the study of diseases of domestic animals - Covers the biology and pathology of diseases of domestic animals on a global basis - Emphasizes the pattern of disease and the defense mechanisms of each organ system - Several new illustrations

Advances in Agronomy

This book has been prepared as an introduction to the chemistry of odorous molecules. While there exist a number of works of an encyclopedic nature which cover this field, there is none which treats the subjectin an instructional fashion. To fill this gap, a group of scientists, types from the chemical point of view, to present to the reader the panorama of those molecules that stimulate the sense of smell. To make the picture complete, the chapters that are strictly chemical in content are preceded by several that introduce the topics of the physiology of the olfactory system, the current hypotheses on the mechanism of the sense of smell, and the structure-odor relationships in odorous molecules. There is also a treatment of analytical techniques which have become important to fragrance chemical research and testing.

Food and Energy Resources provides an understanding of the influence of energy, land, and water resources on food production. Future supplies of energy resources will have a major impact on the ability of humans to provide themselves with food. A better understanding of these issues will help society make sound choices and enable government leaders to develop and organize the necessary programs for the effective use of energy and food resources. The book begins with a discussion of the energy flow in the food system. This is followed by chapters that examine alternatives for the use of the external solar energy; the role of energy in world agriculture and food supply; the energy, land, and labor inputs in several major crop systems in northeastern China; and energy and food relationships in developing countries. Subsequent chapters deal with issues such as the use of renewable energy sources and the extent to which agricultural resources are used to produce food or fuel. This book will provide engineers, economists, agriculturists, geographers, ecologists, nutritionists, sociologists, and natural resource specialists a perspective that will help solve the problem of providing food for people while protecting natural resources.

Advances in Genetics