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Quinone-Based Compounds in Drug Discovery: Trends and Applications provides a comprehensive and up-to-date overview of the latest advances in the field of drug discovery using quinone-based materials. The book covers various aspects of quinone-based materials such as their synthesis, characterization, and applications in drug discovery, consolidating current research. It introduces quinones in the pharmacology context and then describes current developments in drugs for key diseases and conditions. Final chapters deal with the regulatory and commercial framework to take quinone-based drugs to the market. This book will benefit a wide range of readers, including researchers, scientists, and graduate students in the field of drug discovery. Chemists and biochemists will also benefit from the contents of this book. - Covers various aspects of quinone-based materials, including their synthesis, characterization, and applications in drug discovery - Includes specific chapters on antibiotic, neuroprotective, anticancer, antioxidant, and cardio protection through the action of quinones - Incorporates information on the regulatory, intellectual property, commercialization, and clinical development of quinone-based drugs

Molecular Impacts of Nanoparticles on Plants and Algae covers molecular mechanisms of plants/algae related to cellular uptake and translocation of nanoparticles, and genome, transcriptome, proteome, and metabolome responses against it. The book introduces readers to state-of-the-art developments and trends of nanoparticles and plants/algae including interaction of nanoparticles with biological compounds in vitro. Nanoscience and nanotechnology have rapidly been developed in the last few decades, and they have a wide range of applications in industry, medicine, food, and agriculture. In agriculture, nanoparticles (NPs) have successfully been used for growth regulation, crop protection and improvement. They are also employed to cope with plant nutrient deficiencies. A predicted significant increase in the output of NPs will cause the discharge of a remarkable number of NPs to ecosystems, creating a need to understand how to optimize or mitigate their impact depending on their potential impact. These include serious health concerns for living organisms in aquatic, terrestrial, and atmospheric environments as well as human health through their potential existence in plant-based foods. The impact of NPs on living organisms including plants and algae, and uptake, translocation and molecular response mechanisms should be carefully considered before producing and using nanoparticles in large amounts as NPs, when entered to the body, induce changes in gene expressions related to the photosystem, water transport, cell wall formation, and cell division. Further recent studies have showed that NPs are potential agents or stressors to alter proteome, transcriptome, genome and metabolome responses. Impacts of nanoparticles on molecular mechanisms of plants and algae presents the most recent findings on nanoparticle and plant/algae interaction by focusing to molecular response mechanisms at genome, transcriptome, proteome and metabolome levels. In addition, uptake and translocation mechanism of nanoparticles will be assessed both in plant and algae Throughout this book, the latest developments and discoveries will be highlighted as well as open problems and future challenges in molecular mechanisms of plants/algae as a response of nanoparticles. - Presents genome, transcriptome, proteome, and metabolome responses in plants/algae, along with cellular uptake and translocation mechanisms - Illustrates nano-particle-plant/algae interactions - Covers both simple and higher organisms, addressing both algae and plant

Sustainable Plant Nutrition: Molecular Interventions and Advancements for Crop Improvement explores the significant opportunities for sustainable, eco-friendly approaches in plant nutrition and agricultural crop production. The book highlights the various prospects involved in optimizing plant nutrient uptake agriculture and includes chapters representing diverse areas dealing with biotechnology, nanotechnology, molecular biology, proteomics, genomics and metabolomics. This book is an ideal resource for those seeking to ensure a sustainable plant production future. While plants have evolved a set of elaborate mechanisms to cope with nutrient limitations, the traditional supplementation by the application of fertilizers to plant productivity may then lead to overfertilization which can actually reduce plant growth and have adverse effects on the environment. To tackle these issues, a detailed understanding of the responses of plants to nutrients and nutrient deficiency at the physiological, metabolic, transcriptome and epigenetic level is essential. - Illustrates the central role of sustainable plant nutrition to address current and future challenges - Presents global insights and research ranging from signaling to sensing and translational research - Provides a forward-looking perspective for future plans of action

Metals and Metalloids in Soil-Plant-Water Systems: Phytophysiology and Remediation Techniques examines the impact of metal/metalloid contamination on the plant lifecycle, along with microbes present in soil. Highlighting uptake and translocation, the book also examines antioxidant, photosynthesis and growth characteristics of plants grown in metal contaminated soil. Beginning with an introduction to different sources of soil and water pollution, chapters assess the environmental cytotoxicity pollution impact on plants, as well as how the generation of reactive oxygen and nitrogen species in plant tissues is affected. The book also discusses various soil remediation methodologies, including the potential applications of metal oxidizing microbes and nanomaterials. This is an essential resource for researchers and students interested in plant physiology, soil science, environmental science and agriculture. - Provides a comprehensive overview of metal and metalloids speciation, fractionation, bioavailability and transfer to plants - Analyzes properties of plants grown with excess metals/metalloids in soils - Highlights applications of biochar and other biostimulants for sustainable metal/metalloid remediation

Bacterial Fish Diseases: Environmental and Economic Constraints will be useful for researchers and academics who need to understand the nature and consequences of bacteria-related disease in fishes. It has in-depth information on the complete genome of various bacterial species and identifies an essential number of virulence genes that affect the pathogenic potential of the bacteria in fish. Users will find the most relevant information derived from the available bacterial genomes concerning virulence and the diverse virulence factors that actively participate in host adherence, colonization and infection, including structural components, extracellular factors, secretion systems, iron acquisition and quorum sensing mechanisms. This reference is beneficial for understanding economic losses due to bacterial pathogens in fish fauna and its impact on the economy. It addition, it provides information on good aquaculture practices and how to scientifically manage aquaculture and fishery sectors. - Presents bacteria-related diseases in fish species, highlighting problems associated with the culturing of fish - Discusses pollution contamination in freshwater ecosystems to provide insights into the sustainable management of fish species - Provides fundamental research concepts of fish health, along with practical research methods

Phytoremediation: Biotechnological Strategies for Promoting Invigorating Environs focuses on phytoremediation's history, present and future potential, discussing mechanisms of remediation, different types of pollutant and polluted environs, cell signaling, biotechnology, and molecular biology, including site-directed DNA and the omics related to plant sciences. Sections focus on phytoremediation as an economically feasible and environmentally safe strategy, including its mechanisms from macroscopic to microscopic level, strategies of assisted phytoremediation, the role of omics on innovations on the field, the development of genetically modified plants (GMPs) to deal with pollutants, the future prospects of targeted genetic engineering in phytoremediation and remediation advantages and disadvantages. Other sections in the book explore the phytoremediation of specific environs (water and soil) and specific contaminants that are of major worldwide concern. - Presents phytoremediation mechanisms at a microscopic level (molecular mechanisms) - Covers remediation in different environs and in different kinds of pollutants - Conveys the economic aspects relating to phytoremediation

Phytomedicine: A Treasure of Pharmacologically Active Products from Plants aims to present updated knowledge of plant-based medicines in terms of their research and development, production, and utilization, from the viewpoint of sustainability and by using the latest technologies. The book explores different phytometabolites on a mass scale, coupled with the efficacy, performance and applicability on target organisms to treat curable and fatal diseases. Readers will find a coherent package of phytotherapeutic information regarding inclusive assortment of research based, scientific amplitude of metabolites from the plant world encompassing various action plans. Information is presented sequentially regarding phytochemistry, biological activity and the serviceable aspects of bioactive compounds. The book also addresses various advancements and achievements of novel drugs from plants using molecular and enzymatic activities, and various technological tools in an ecofriendly fashion. - Discusses phytotherapeutic properties for a wide range of medical conditions, including anti-pyretic, anti-infective, anti-malarial, Anti-AIDS, anti-diabetic, anti-cancerous, immune-modulatory applications - Includes a discussion of synergistic effects of formulations and antagonistic drug interactions - Addresses advancements and achievements of novel plant-based drugs using molecular, enzymatic activities and various technological tools in an eco-friendly fashion

Plants face a wide range of environmental challenges, which are expected to become more intense as a result of global climate change. Plant–soil interactions play an important role in the functioning of ecosystems. Soil properties represent a strong selection pressure for plant diversity and influence the structure of plant communities and biodiversity. The complexity of plant–soil interactions has recently been studied by developing a trait-based approach in which responses and effects of plants on soil environment are quantified and modelled. This fundamental research on plant–soil interaction in ecosystems is essential to transpose knowledge of functional ecology to environmental management.Frontiers in Plant-Soil Interaction: Molecular Insights into Plant Adaptation will address topics that provide advances in understanding plant responses to soil conditions through the integration of genetic, molecular, and plant-level studies of diverse biotic and abiotic stresses under field and laboratory conditions. This book will be beneficial to students and researchers working on stress physiology and stress proteins, genomics, proteomics, genetic engineering and other fields of plant-soil interactions. Frontiers in Plant-Soil Interaction will also help scientists explore new horizons in their area of research. - Brings together global leaders working in the area of plant–environment interactions and shares their research findings - Presents current and future scenarios for the management of stressors - Illustrates the central role for plant-soil interactions in applying basic research to address current and future challenges to humans

Growing consumer interest in organic and herbal-based products has led to great demand in the botanicals industry in the past few years. However, the growing number of products utilizing medicinal and aromatic plants (MAPs) has threatened an estimated 9,000 medicinal plant species worldwide, making it critical to reevaluate their research and development, production, and utilization. Continuing advances in Omics methodologies and instrumentation are essential to understanding how plants cope with the dynamic nature of their growing environment, how yields and characteristics can be improved, and how to most effectively direct conservation efforts. With a focus on metabolomics, genomics, proteomics, transcriptomics, and more, Medicinal and Aromatic Plants: Expanding Their Horizons through Omics illustrates the genetic mechanisms of MAPs, providing a better understanding of MAPs conservation and methods to improve characteristics for medical applications. With an introduction on the role of MAPs in human health, subsequent chapters discuss using proteomics to increase MAP yields and plant quality, genome editing, and CRISPR/Cas9. A valuable resource for farmers, scientists, chemists, biochemists, pharmacists, and students interested in medicinal and aromatic plants and plant biology, Medicinal and Aromatic Plants: Expanding Their Horizons through Omics ensures readers have the background knowledge to put the necessary methodologies into practice themselves. - Includes in-depth analysis of Omics technologies for the enhancement of MAPs - Discusses applications of MAPs including their role in human health Written by world-wide leading experts in the field