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Purpose: This study aims to assess the diagnostic yield of routine EEG (rEEG) followed by long-term ambulatory EEG (aEEG) in a retrospective cohort, focusing on the rates of abnormal EEG findings, and overall event capture., Methods: Data were retrospectively collected from deidentified clinical reports of patients who underwent both rEEG and subsequent aEEG, with both modalities including video recordings. The study included 95 patients, with demographic, clinical information, and EEG findings extracted for analysis. Statistical analyses included chi-squared proportion tests and Wilcoxon rank-sum tests to assess the influence of variables such as age, sex, referral source, and aEEG duration on outcomes. Bayes factors were calculated to evaluate the power of the statistical tests., Results: Among the 95 patients, 33 % were 16 years old or younger. The median duration of aEEG was 3.9 days. Abnormal EEG findings increased from 18 % with rEEG to 33 % with aEEG. Epileptic seizures were captured in 3 % of rEEG and 8 % of aEEG, while non-epileptic events were captured in 35 % of aEEG compared to none in rEEG. Younger age was associated with higher rates of abnormal findings, but this was not adequately powered. Females had a higher likelihood of event capture on aEEG, though this finding was also underpowered. The majority of adult and paediatric patients with a normal rEEG went on to have a normal aEEG., Conclusion: Ambulatory EEG significantly improves the diagnostic yield for both epileptic and non-epileptic events compared to routine EEG, particularly in adults. This study supports the broader use of aEEG for comprehensive epilepsy evaluation and suggests further research to optimise its clinical utility., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [ESN, DRF, and MJC all have financial interests in Seer Medical Holdings Limited]., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)

Introduction: Children with epilepsy report lower health-related quality of life (QOL) compared with healthy children and those with other chronic disorders. This study piloted the recently published Pediatric Quality of Life Inventory (PedsQL) Epilepsy Module (PedsQL-EM) in an ambulatory setting and studied epilepsy-related factors contributing to QOL in children with epilepsy., Methods: Children with epilepsy aged 8-18 years who were ambulant and verbal were recruited from pediatric neurology clinics. Children and their caregivers completed age-appropriate versions of the PedsQL-EM (8-12 or 13-18 years) in the clinic waiting area. Treating neurologists completed medical questionnaires about their patients' epilepsy., Results: We collected 151 parent-report and 127 self-report PedsQL-EMs. Administration time was 5-10 min with some children receiving assistance from the researcher. Mean age of children was 12.9+/-3.0, with 77 females (51%). Parents reported lower mean QOL scores across all subdomains compared with their children. Parents reported significantly lower QOL for children with earlier age at epilepsy onset, longer epilepsy duration, presence of seizures during the last month, more severe epilepsy, increased number of antiepileptic drugs (AEDs), and cognitive comorbidity. The same factors impacted on child self-reporting, but with more variability across subdomains., Conclusions: The PedsQL-EM is an epilepsy-specific measure of QOL that is quick and easy to administer and is sensitive to the clinical factors reported to impact on QOL in pediatric epilepsy., (Copyright © 2020 Elsevier Inc. All rights reserved.)