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Cell-based Cancer Immunotherapy, Volume 183 provides the latest progress concerning research on anticancer cellular immunotherapies and their immunological, translation, or clinical aspects. Topics covered in this volume include Methods behind clinical DC vaccine products against glioblastoma, Fully closed and automated isolation of natural blood dendritic cells for cancer immunotherapy, Methods behind Oncolytic virus-based DC vaccines in cancer: towards a multiphase combined treatment strategy for Glioblastoma (GBM) patients, Identification of TCR repertoire patterns linked with anti-cancer immunotherapy, Training of epitope-TCR prediction models with healthy donor-derived cancer-specific T cells, Methods behind neoantigen predictions for anticancer vaccines, Methods behind CD137L-DC-EBV-VAX anticancer vaccine, and much more. Additional sections cover Gold Standard Assessment of Immunogenic Cell Death Induced by Photodynamic Therapy: From In Vitro to Tumor Mouse Models and Anti-Cancer Vaccination Strategies, Methods behind TCR analyses for colorectal cancer-associated TILs, The use of xCELLigence, Incucyte, and/or Cr/LDH/maker-release assays, Humanized mouse models for anti-cancer therapy, In vitro re-challenge of CAR T cells, Methods behind adoptively transferred tumor draining lymphocytes? for anticancer immunotherapy, and A murine glioblastoma platform to test cellular therapies with the standard of care. - Provides comprehensive method articles from front-line experts on the topic of anticancer cellular immunotherapies - Provides useful schematic material and cutting-edge discussions - Presents the latest insights and future perspectives on the covered topics, along with their implications for immuno-oncology, as well as clinical perspectives

Pili in Mycobacterium Tuberculosis: Structure, Function, and Therapeutic Advances discusses the types of pili produced by the tuberculosis-causing bacterium, Mycobacterium tuberculosis (MTBC. The book examines the structure of pili shown under electron and atomic force microscopy and by using whole genome sequencing, outlines the importance of pili in mycobacterium tuberculosis. It also explores the role of pili in bacteria-host interactions and in drug development and delivery. Pili in Mycobacterium Tuberculosis opens with an overview of the structure, synthesis, and function of pili in bacteria. This includes taxonomy and the role of pili in diseases. The book also examines the preparation of Mycobacterium tuberculosis for electronic and atomic microscopy and looks at the different life cycles and susceptibility patterns of MTBC. It does on to discuss the expression and function of pili using whole genome sequencing and PCR-based methods and delves into bacteria host interactions. Lastly, it explores the development of new drugs and its delivery by pili. - Covers the structure, synthesis, and function of pili produced by the tuberculosis-causing bacterium, MTB - Introduces seven types of pili in MTB - Explains the mechanism of bacteria–host attachment and importance of this phenomena in MTB pili and other bacteria - Emphasizes the use of advances techniques to study and investigate the TB-bacilli and its interaction with host cells

Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic'step by step'manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics as well as omics technology policy and society research. Integrative Omics: Concepts, Methodology and Applications highlights the recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science. The book bridges the gap between biological sciences, physical sciences, computer science, statistics, data science, information technology and mathematics by presenting content specifically dedicated to mathematical models of biological systems. - Provides a holistic, integrated view of a defining and applying network approach, integrative tools, and methods to solve problems for rationalization of genotype to phenotype relationships - Offers an interdisciplinary approach to Databases, data analytics techniques, biological tools, network construction, analysis, modeling, prediction and simulation of biological systems leading to'translational research', i.e., drug discovery, drug target prediction, and precision medicine - Covers worldwide methods, concepts, databases, and tools used in the construction of integrated pathways

Immunotherapeutics, Volume 129 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Vaccines for the prophylaxis and treatment of HPV, Lung-targeted RNA-based therapeutics, Clostridium difficile: Current overview and future perspectives, Antivenoms for treatment of snake bites, Natural killer cell-based strategies for immunotherapy of cancer, Immunological insights of selectins in human disease mechanism, Current update, challenges, and future aspects of immunotherapeutics in non-small cell lung cancer, In silico interaction analysis of NEMO binding domain peptide on the NFkB protein, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Protein Chemistry and Structural Biology series - Updated release includes the latest information on Immunotherapeutics

Immunological Implications and Molecular Diagnostics of Genitourinary Cancer updates on recent accomplishments, unifying concepts, and future challenges in the study of tumor-associated immune cells, emphasizing genitourinary cancers. The presence of inflammatory immune cells in human tumors raise a fundamental question: How do cancer cells avoid destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells, however, as tumors develop from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms. This book covers research on the immunological implications of genitourinary cancer with a comprehensive view, especially surrounding diagnosis and cellular mechanisms. - Discusses the impact of the immune system on the initiation, progression and treatment of cancer - Provides insights on the important role of the suppressor genes and oncogenes in genitourinary cancers - Shows the advantages of combining clinical issues of urologic cancers with immunological techniques, like immunohistochemistry and immunofluorescence - Demonstrates the implications genitourinary cancer has on the human innate immune system

The first and second editions of Medical and Veterinary Entomology, edited by Gary R. Mullen and Lance A. Durden, published in 2002 and 2009, respectively, have been highly praised and become widely used as a textbook for classroom instruction. This fully revised third edition continues the focus on the diversity of arthropods affecting human and animal health, with separate chapters devoted to each of the taxonomic groups of insects and arachnids of medical or veterinary concern, including spiders, scorpions, mites, and ticks. Each chapter includes sections on taxonomy, morphology, life history, and behavior and ecology, with separate sections on those species of public-health and veterinary importance. Each concludes with approaches to management of pest species and prevention of arthropod-borne diseases. The third edition provides a comprehensive source for teaching medical and/or veterinary entomology at the college and university level, targeted particularly at upper-level undergraduate and graduate/postgraduate programs. In addition to its value as a student textbook, the volume has appeal to a much broader audience, specialists and non-specialists alike. It provides a key reference for biologists in general, entomologists, zoologists, parasitologists, physicians, public-health personnel, veterinarians, wildlife biologists, vector biologists, military entomologists, the general public and others seeking a readable, authoritative account on this important topic. - Completely revised and updated edition - Includes a distinguished group of 40 nationally and internationally recognized contributors - Sixteen new authors, in addition to 25 continuing contributors from the first and second editions - A new chapter on Arthropod Toxins and Venoms - Illustrated with 560, mostly color, figures and updated maps depicting the distribution of important arthropod taxa and arthropod-borne diseases - A significantly expanded and well-illustrated chapter on Molecular Tools Used in Medical and Veterinary Entomology - Coverage of emerging and newly recognized arthropod concerns, including mosquito-borne Zika and - Chikungunya viruses; tick-borne Bourbon and Heartland viruses; tick-borne rickettsioses and anaplasmosis; and red meat allergy associated with tick bites - A 1700-word Glossary - An Appendix of Arthropod-Related Viruses of Medical and Veterinary Importance

Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment is the first book to take an interdisciplinary approach to the understanding of cannabis use and misuse. Recent worldwide trends toward decriminalizing marijuana for medical use have increased legal use of the drug and recreational use remains high, making cannabis one of the most commonly used drugs. Cannabis has a wide range of adverse neurological effects, and use and abuse can lead to physical, social, and psychopathological issues that are multifarious and complex. Effective understanding and treatment requires knowledge of the drug's effects from across scientific disciplines. This book provides an overview of the biological and pharmacological components of the cannabis plant, outlines its neurological, social, and psychopathological effects, assists in the diagnosis and screening for use and dependency, and aids researchers in developing effective treatments for cannabis-related issues and disorders. Fully illustrated, with contributions from internationally recognized experts, it is the go-to resource for neuroscientists, pharmacologists, pathologists, public-health workers, and any other researcher who needs an in-depth and cross-disciplinary understanding of cannabis and its effects. - Comprehensive chapters include an abstract, key facts, mini dictionary of terms, and summary points - Presents illustrations with at least six figures, tables, and diagrams per chapter - Provides a one-stop-shopping synopsis of everything to do with cannabis and its related pathology, from chemicals and cells, individuals and communities, and diagnosis and treatment - Offers an integrated and informed synopsis of the complex issues surrounding cannabis as a substance, its use, and its misuse

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. - Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics - Identifies key concepts, methods, and findings - Includes coverage of multiple disorders from autism to schizophrenia - Reviews specific genes associated with disorders - Discusses the genetic architecture of these syndromes - Explains how recent findings are influencing the understanding of biology - Clarifies the promise of these findings for future treatment

Computer Simulation in Human Population Studies contains the proceedings of a conference held at Pennsylvania State University on June 12-14, 1972, under the sponsorship of the Social Science Research Council. The conference provided a forum for discussing the application of computer simulation techniques to human population studies and organized topics around four themes: anthropology and social systems; genetics and adaptive systems; demography; and simulation methodology. Comprised of 23 chapters, this volume begins with an analysis of two tests of computer microsimulation: the effect of an incest taboo on population viability, and the effect of age differences between spouses on the skewing of their consanguineal relationships. The reader is then introduced to computer simulation of incest prohibition and clan proscription rules in closed, finite population; an empirical perspective on simulation models of human population; and models applicable to geographic variation in humans. Subsequent chapters deal with the role of co-adapted sets in the process of adaptation; simulation of human reproduction; and the mathematics of population simulation models. This book will be of interest to anthropologists, geneticists, biologists, computer scientists, mathematicians, and social scientists.

Advances in Behavioral Pharmacology, Volume 3 covers papers dealing with various aspects of the ways in which drug effects are related to and perhaps modified by the rate of responding. The book discusses the behavioral actions of benzodiazepines and considers the extent to which these actions are consistent with the proposition that these effects are partially or entirely determined by control rates of responding. The text then describes rate-dependence and the effects of phenothiazine antipsychotics in pigeons; the rate-convergent effects of drugs; and the rate-dependent effects of extra stimuli, of drugs, and drug-state change. Historical, mathematical and alternative considerations in quantitation in behavioral pharmacology, as well as the history and status of rate-dependency investigations are also considered. The book then tackles the scope and limitations in the explanation and analysis of the behavioral effects of drugs; drug effects on behaviors maintained by different events; and the importance of identifying which of these factors contributes to the behavior studied in any given experiment. Pharmacologists, psychologists, psychiatrists, and students taking these disciplines will find the book useful.

For decades, Emery and Rimoin's Principles and Practice of Medical Genetics has provided the ultimate source for practicing clinicians to learn how the study of genetics can be integrated into practice. With almost 5,000 pages of detailed coverage, this fully online sixth edition of the classic reference adds the latest information on prenatal diagnosis, genetic screening, genetic counseling, and treatment strategies to complete its coverage of the growing field for medical students, residents and physicians involved in the care of patients with genetic conditions. Clinically oriented information is supported by expanded sections on basic principles of genetics, research approaches, and analytics to embrace the evolving population of students, researchers, and practitioners who are integrating their work to provide advanced diagnosis, prevention and treatment of human disease. With advances in high-throughput technologies propelling the closer integration of lab and clinical work, this edition bridges the gap between high-level molecular genetics and clinical application. - Features 174 review-length contributions that encompass traditional and new areas of the field - including in cancer genetics, genomic technologies, and molecular assays - Provides many thousands of pertinent literature references guiding the reader in identifying related topics - Fully illustrated with hundreds of color images, supporting identification, concept illustration and method processing

Development of the Nervous System presents a broad and basic treatment of the established and evolving principles of neural development as exemplified by key experiments and observations from past and recent times. The text is organized ontogenically. It begins with the emergence of the neural primordium and takes a chapter-by-chapter approach in succeeding events in neural development: patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, neuron survival and death, synapse formation and developmental plasticity. Finally, in the last chapter, with the construction phase nearing completion, we examine the emergence of behavior. This new edition reflects the complete modernization of the field that has been achieved through the intensive application of molecular, genetic, and cell biological approaches. It is richly illustrated with color photographs and original drawings. Combined with the clear and concise writing, the illustrations make this a book that is well suited to students approaching this intriguing field for the first time.Features - Thorough survey of the field of neural development - Concise but complete, suitable for a one semester course on upper level undergraduate or graduate level - Focus on fundamental principles of organogenesis in the nervous system - Integrates information from a variety of model systems, relating them to human nervous system development, including disorders of development - Systematically develops knowledge from the description of key experiments and results. - Organized ontologically - Carefully edited to be presented in one voice - New edition thoroughly updated and revised to include major new findings - All figures in full color, updated and revised - Specific attention on revising the chapter on cognitive and behavioral development to provide a foundation and outlook towards those very fast moving areas - Instructor website with figure bank and test questions Benefits - The only thorough textbook of Developmental Neuroscience on the market - Carefully structured and edited to map onto the syllabus of most developmental neuroscience courses - Priced to be affordable for undergraduates even in addition to broader textbooks - Carefully constructed instructor's website - Specifically designed to make teaching of complicated subjects easy and fun for instructors and students alike

Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, Cell Mechanics has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. - Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions - Includes highly significant topics relevant to basic and translational research, as well as tissue engineering - Emphasizes mechanical input and output of cells

International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address therapeutic strategies for duchenne and becker dystrophies, cellular distribution and functions of P2 receptor subtypes in different systems, neuropeptides in hypothalamic neuronal disorders, and multiple parallelisms in animal cytokinesis.

Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.

Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic chemistry and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain.• Thousands of literature references provide introduction to current research as well as historical background• Contains twice the number of chapters of the first edition• Each chapter contains boxes of information on topics of general interest

Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic biochemistry, associated chemistry, and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain.• Thousands of literature references provide introduction to current research as well as historical background • Contains twice the number of chapters of the first edition • Each chapter contains boxes of information on topics of general interest

Coral Reef Fishes is the successor of The Ecology of Fishes on Coral Reefs. This new edition includes provocative reviews covering the major areas of reef fish ecology. Concerns about the future health of coral reefs, and recognition that reefs and their fishes are economically important components of the coastal oceans of many tropical nations, have led to enormous growth in research directed at reef fishes. Coral Reef Fishes is much more than a simple revision of the earlier volume; it is a companion that supports and extends the earlier work. The included syntheses provide readers with the current highlights in this exciting science. - An up-to-date review of key research areas in reef fish ecology, with a bibliography including hundreds of citations, most from the last decade - Authoritative, up-to-date, provocative chapters written to suggest future research priorities - An important companion and successor to The Ecology of Fishes on Coral Reefs - Includes discussions of regulation of fish populations, dispersal or site fidelity of larval reef fishes, sensory and motor capabilities of reef fish larvae, and complexities of management of reef species and communities

The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. - Provides in-depth description of targeted systems and treatment strategies - Explains the underlying cancer biology necessary for understanding a given therapeutic approach - Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses - Presents translational focus with emphasis on requirements for clinical implementation - Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

The most comprehensive textbook/reference ever to cover the chemical basis of life, the'Green Bible of Biochemistry'has been a well-respected contribution to the field for more than twenty years. The complex structures that make up cells are described in detail, along with the forces that hold them together, and the chemical reactions that allow for recognition, signaling and movement. There is ample information on the human body, its genome, and the action of muscles, eyes, and the brain. The complete set deals with the natural world, treating the metabolism of bacteria, toxins, antibiotics, specialized compounds made by plants, photosynthesis, luminescence of fireflies, among many other topics.• The most comprehensive biochemistry text reference available on the market• Organized into two volumes, comprising 32 chapters and containing the latest research in the field• Biological content is emphasized: for example, macromolecular structures and enzyme action are discussed

This is the first high-quality, comprehensive overview of the field of evolutionary protein design. Topics include new protein design strategies, the structures of laboratory-evolved proteins, the evolution of non-natural enzyme functions, and the theory of laboratory evolution.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. - The Yin Yang of TCF/b-Catenin Signalling - Biochemical and Clinical Implications of the Erb/HER Signaling Network of Growth Factor Receptors - p53 and Human Cancer: The First Ten Thousand Mutations - Macrophage Stimulating Protein - CD44 Glycoproteins in Colorectal Cancer; Expression; Function; and Prognostic Value - A Simple Modes for Carcinogenesis of Colorectal Cancer with Microsatellite Instability

Development of the Nervous System presents a broad outline of neural development principles as exemplified by key experiments and observations from past and recent times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. Original, artist-rendered drawings combined with clear, concise writing make Development of the Nervous System well suited to anyone approaching this complex field for the first time.Key Features• Provides a synopsis of concepts and experimental strategies• Includes designs of critical experiments that are easy to understand• Outlines the molecular and genetic bases for many developmental events• Presents new information on the function of the developing central nervous system • Richly illustrated with original drawings• Treats the field as an experimental rather than a descriptive science• Written at a level that is appropriate for undergraduates and beyond

Proteases are enzymes that essentially'eat'protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search.Proteases of Infectious Agents collects reviews from leading experts describing the latest information on the properties of key enzymes from a variety of viruses, fungi, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area. - Includes information on the basic biology and function of proteases - Provides global survey of current research efforts in protease inhibitors - Illustrates how structure-based drug design targets effective and selective compounds - Highlights important diseases that provide economically important targets - Describes the role of proteases as important new targets for drug discovery

This widely-acclaimed serial contains authoritative reviews that address all aspects of organometallic chemistry, a field which has expanded enormously since the publication of Volume 1 in 1964. Almost all branches of chemistry and material science now interface with organometallic chemistry--the study of compounds containing carbon-metal bonds. Organometallic compounds range from species which are so reactive that they only have a transient existence at ambient temperatures to species which are thermally very stable. Organometallics are used extensively in the synthesis of useful compounds on both large and small scales. Industrial processes involving plastics, polymers, electronic materials, and pharmaceuticals all depend on advancements in organometallic chemistry.

Women and Health is a comprehensive reference which addresses health issues affecting women of all ages--adolescence through maturity. It goes far beyond other books on this topic which concentrate only on reproductive health, and has a truly international perspective. It covers key issues ranging from osteoporosis to breast cancer and other cancers, domestic violence, sexually transmitted diseases, occupational hazards, eating disorders, heart disease and other chronic illnesses, substance abuse, and societal and behavioral influences on health. Women and Health covers not only those conditions that are unique to or occur more frequently in women, but also those that present differently or are treated differently in women.Key Features:• Comprehensive, in-depth review of all aspects of women's health• Highlights key women's health issues including osteoporosis, domestic violence, breast cancer, menopause, infertility, heart disease, and many others• Addresses international women's health issues from a human rights and cultural perspective• Presents the latest research and clinical findings from leaders in their respective fields• Highlights controversies in treatment modalities• Challenges the medical community to address the impact of gender on health• Expands our thinking about the perceptions of disease and disorders in women• Challenges current status quo in health care delivery

Advances in Behavioral Pharmacology, Volume 1 provides synthetic and analytic reviews of significant areas of behavioral pharmacology, particularly the behavioral mechanisms of drug action. The book presents papers on the behavioral pharmacology of the tetrahydrocannabinols; on infrahuman ethanol self-administration; and on the discriminative stimulus properties of drugs. The text then describes various methods used to study the effects of drugs on discrimination; signal detection (SDT), which attempts to separate effects of variables on discrimination processes or capacity (sensitivity) from effects on the subject's criterion; and some of the uses of this model in behavioral pharmacology. The rate-dependency of the behavioral effects of amphetamine, as well as some of the major events in the history of behavioral pharmacology are also considered. The book concludes by tackling the status of behavioral pharmacology. Behavioral pharmacologists, pharmacologists, physicians, and students taking pharmacology and medicine will find the book useful.

Methods for Studying Mononuclear Phagocytes is a practical guide to the study of mononuclear phagocytes that brings together various well-established and useful methods for examining these cells. The technical protocols have been made detailed, specific, practical, and inclusive of the necessary mystique for immediate and direct application in the laboratory. The book is divided into 11 parts arranged according to the sequence of steps that would generally be followed to study a given population of mononuclear phagocytes: (I) methods for obtaining and culturing populations of human and animal mononuclear phagocytes; (II) methods for separating populations of leukocytes to enrich or deplete their content of mononuclear phagocytes; (II) criteria and techniques for identifying mononuclear phagocytes; (IV) methods for quantifying the number of mononuclear phagocytes; (V) techniques for studying the morphology of mononuclear phagocytes; (VI) methods for quantifying the biochemical constituents of mononuclear phagocytes; (VII) methods of quantifying phagocytosis, pinocytosis, and chemotaxis; (VIII) methods for quantifying the secretory products of mononuclear phagocytes; (IX) procedures for quantifying the destruction of tumor cells and of microorganisms by mononuclear phagocytes; (X) methods for studying the cell biology of mononuclear phagocytes; and (XI) techniques for studying mononuclear phagocytes in vivo, including procedures for estimating their kinetics, accumulation, identification, and microbicidal properties.

The Cannabinoids: Chemical, Pharmacologic, and Therapeutic Aspects provides a comprehensive discussion of the various aspects of cannabis and its constituents. The book is organized into six sections. Section I covers the clinical aspects of cannabis including the health aspects, impact on memory function, and the characteristics and treatment of marijuana abusers. Section II on chemical aspects includes studies on the chemistry and structure-activity relationships of cannabinoids; smoking characteristics of marijuana cigarettes; and developments in cannabinoid analyses of body fluids. Section III on metabolic and pharmacokinetic aspects includes studies on the metabolism, disposition, and pharmacokinetics of delta-9-tetrahydrocannabinol (THC) in men and women; single dose kinetics of cannabidiol in man; and distribution and disposition of THC in different tissues of the rat. Section IV on reproductive aspects include studies on the effects of chronic administration of THC on the early embryonic development of mice; effects of cannabinoids on spermatogenesis in mice; and possible mechanism for the cellular effects of marijuana on male reproductive function. Section V on neuropharmacologic aspects includes studies on the discriminative stimulus properties of THC and the effects of cannabinoids on neurotransmitter receptors in the brain. Section VI on therapeutic aspects includes studies such as the possible anxiolytic effects of cannabidiol; tetrahydrocannabinol effects on extrapyramidal motor behaviors in Parkinson's disease; and the use of cannabinoids in glaucoma.

Advances in Genetics continues to present articles that are of interest to both human and molecular geneticists. Volume 37 offers a single chapter, written by I.F. Zhimulev, in which Dr. Zhimulev undertakes thelaborious task of presenting an in-depth and detailed account of the various aspects of heterochromatin organization in the mitotic and interphase polytene chromosomes. It also includes details concerning the organization of heterochromatin at high resolution are also analyzed.

Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.This volume of Advances in Genetics continues the series goal to present both human and molecular genetic reviews in a timely fashion. Anderson and Kay investigate CAB gene expression in the regulation of gene transcriptions in plants. Harmon and Allan offer a historical overview of apoptosis and its recent heightened interest. Developments involving four X-linked disorders and their resulting increased susceptibility to infection are presented by Smithand Notarangelo. Dickson and colleagues present research on the role of dystrophin in Duchenne muscular dystrophy and the potential feasibility of gene therapy in curing this disease as well as other diseases involving the heart and central nervous system. The relationship between mice and humans and the ways in which they help each other understand gene function and relationship is presented by Elizabeth Fisher. Timmons and Shearn summarize what information has been learned about prune, Killer of prune, and the prune/Killer of prune lethal interactions: rare genetic phenomena in Drosophila melanogaster. Meiotic recombination, via the breaking and rejoining of DNA and the subsequent reciprocal exchange and the cytological evidence of the exchange, are explored by Ross et al. Last, Coonar and McKenna discuss the four major cardiomyopathies, focusing on recent advances in hypertrophic cardiomyopathy.

Advances in Genetics increases its focus on modern human genetics and its relation to medicine with Volume 33 of this long-standing serial. The recent merger of Molecular Genetic Medicine with Advances in Genetics affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.In this volume, Petes and Pukkila synthesize the latest research on meiotic recombination, with specific reference to crossover and gene conversions. The'absurd size and complex'structure of the Dystrophin gene is considered in another chapter, with discussions of strategies for future diagnosis and treatment of muscular dystrophy. Two chapters also examine the molecular genetics of sex determination, including the influence of maternal age and resulting chromosomal aberrations. Volume 33 also includes a review of the PAX and HOX gene families and their links to the developmental process, cellular growth control, and forms of cancer. Case studies of thrombophilia, Menkes, and Wilson diseases are used to exemplify the genetic disorders of blood clotting, copper deficiency, and toxicity, respectively. Triman takes a genetic approach to understanding the function of ribosomal RNA using E. coli as the model best able to reveal the inherent complications of the translation process. Leach and O'Connell describe the use of radiation hybrids for constructing high-resolution maps of the human genome. With these reviews the alliance of Molecular Genetic Medicine with Advances in Genetics is completed under the banner of Advances in Genetics.Key Features• Presents technical and historical overviews of molecular biology applied to disease detection, diagnosis, and treatment• Chronicles the continuing explosion of knowledge in molecular genetic medicine by highlighting current approaches to understanding human illness• Documents the revolution in human and molecular genetics leading to a new field of medicine• This volume highlights Analysis of human chromosomes with chapters on pathology of sex determination and numerical chromosomal abnormalities Molecular and genetic bases of muscular dystrophy and Menkes and Wilson diseases Techniques including FISH, IRS-PCR, and radiation hybrids

The Joints and Synovial Fluid II is a collection of papers that deals with the basic aspects of the articular apparatus, including the general pathology of the appendicular and axial structures, the disease processes, and comparative anthology. Some papers discuss in vitro culture of joints and articular tissues, the chemistry of the ground substance of joint cartilage, and the structure of the intervertebral disc in relation to its function and to the aging process. As a humans being ages, the whole nucleus found in the disc will behave more like a sponge than a shock absorber as regards its ability to distribute stress and pressure from the end plates of the disc. Another paper describes load distribution of the knee, ankle joint, the spine, the arms, elbows, fingers. One paper deals with the pathology of the spine covering infectious diseases, metabolic and developmental disease of cartilage and bones, traumatic and degenerative diseases, autoimmune connective tissue diseases (such as ankylosing spondylitis), and miscellaneous diseases (such as tumors). The collection is suitable for researchers, scientists, medical practitioners, and academicians in the fields of biochemistry, bioengineering, anatomical sciences, immunology, organ physiology, cell biology, orthopedics, rheumatology, or rehabilitation medicine.

Radioastronomical Methods of Antenna Measurements

Nutrition and Drug Interrelations examines and presents the different relations of nutrition, metabolism, and effects of drugs, including drugs'positive effects in the field of animal husbandry and human and veterinary medicine. This book also highlights the importance of the interrelations between nutrition and drugs. The introductory chapter gives an overview of the variable role of food in humans on a historical and sociological context and perspective. The first section of this book deals with the impacts of drugs on the nutrition process. These impacts can either be harmless or harmful depending on the adequacy of nutrition. The second section of this book describes some of the many influences of nutritional condition on biochemical competence to cope with xenobiotics, including drugs. The third section highlights the various uses of pharmacological agents in food production. This section also discusses some concerns about the effect in the food chain of pharmacological agents. The last section in this book demonstrates the overlap in boundary between dietetic and pharmacological treatments. Given focus is the use of vitamin D derivatives and megavitamin treatments with doubtful benefits. This book will benefit most students and professionals in the field of food and nutrition, human and veterinary medicine, and animal husbandry. The subject area in this book will also yield interest from people involved in metabolism, nutrition, and pharmacology.

Advances in Inorganic Chemistry and Radiochemistry

Methods in Muscle Biology is a comprehensive laboratory guide that details the methods used in the study of muscle biology. The techniques included embrace cell, developmental, and molecular biology, as well asphysiology, neurobiology, and medical research.

Chromatin and Chromosomal Protein Research II

METHODS OF EXPERIMENTAL PHYSICS V.12C

The Cell Nucleus: Chromatin, Part A is a collection of papers that deals with the fundamental research involving cellular responses to environmental stimuli and stress. One paper describes the ultra-structural organization of chromosomes and certain eukaryotic chromatin fractions as seen by a scanning electron microscope. The researcher investigating chromatin three-dimension ultra-structure is presented with two choices to address the technical limitations of SEM at different levels, namely, (1) electron microscope modality and (2) specimen preparation procedures. Another paper explains the extensive postmortem changes in properties occurring in nuclear preparations during purification and handling. The analysis of the digestion products when mammalian nuclei are digested with endogenous and exogenous nucleases can show the organization structure of the cell nucleus. When treated with Ca-Mg or micrococcal endo-nuclease, the different nuclear or chromatic preparations present near identical digestion patterns. Another paper reviews the occurrence of phase-specific nuclear proteins in the Physarum mitotic cycle, as well as their possible role in the control of DNA replication order in Physarum. The collection can prove valuable to bio-chemists, cellular biologists, micro-biologists, developmental biologists, and scientists involved in cellular investigations.

Neuroendocrine Peptide Methodology

Modulation of Protein Function, Volume XIII, presents the proceedings of the ICN-UCLA Symposium on Molecular and Cellular Biology held in Keystone, Colorado, from February 25-March 2, 1979. The symposium aimed to bring together workers from several fields, all of which deal with the modulation of protein function. The discussion of representative metabolic control systems, ranging from single enzyme responses to complex regulatory cascades, and the control of photosynthesis and of protein synthesis and enzyme inactivation, dealt with the general topic at perhaps its most fundamental cellular level. Modulations and conformational changes in proteins that underlie higher-level interactions, such as those involved in cyclic nucleotide function, sensing and chemotactic response to foreign materials, and the complement system, were also described. Two talks dealt with potential clinical relevance of phenomena of the types described by other participants. The book is organized into nine parts with papers covering the following topics: modulation of enzymes of intermediary metabolism (Part I); modulation and inactivation (Part II); photosynthesis and storage polysaccharides (Part III); cascade systems (Part IV); protein phosphorylation (Part V); methylation in chemotaxis (Part VI); cyclic GMP and cyclic CMP (Part VII); protein synthesis (Part VIII); and clinical implications (IX).

Biomolecular Structure and Function covers the proceedings of the 1977?Cellular Function and Molecular Structure: Biophysical Approaches to Biological Problems? symposium. It summarizes the application of several biophysical techniques to molecular research in biology. This book starts by describing the use of deuterium-labeled lipids, as monitors of the degree of organization of membrane lipids. It also describes the use of carbon-13-labeled lipids, as indicators of molecular mobility. It explains the lipid-protein interactions involving two integral membrane proteins, mitochondrial cytochrome oxidase and calcium-dependent ATPase of muscle sarcoplasmic reticulum. The book goes on to present NMR studies on the organization and conformation of phospholipids, chloroplast membranes, and erythrocyte membranes. It also presents the ESR study of spectrin-phospholipid associations. It discusses the use of fluorescence probes, electrokinetics, neutron diffraction and ion theory studies of phospholipid-protein association, hormone disease, and senescence effects on prokaryotic and eukaryotic cells. Moreover, this book presents the experiments and phosphorus-31 NMR methodology to simultaneously monitor the intracellular pH and phosphate metabolism in a beating heart, functioning kidney, or an intact living microorganism. This book then describes physical probing of intracellular fluidity and structural changes attending tissue or cell cycles. It also relates relatively narrow lines in the hydrogen-1 NMR spectrum of the extremely viscous complex of the muscle protein troponin and highly polymerized tropomyosin. Structure-function studies of fibrous proteins, such as collagen, actin, and myosin, and active site analysis of enzymes are also presented. Finally, a wide variety of methodologies and technologies is exemplified. This includes proton, carbon, fluorine, phosphorus, and lithium NMR spectroscopy; spin labeling and EPR spectroscopy; chemical studies; light scattering and fluorescence; and electron microscopy.

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. Volume 40, GeneTherapy, features important new research on gene transfers and therapy in the herpes simplex virus, anti-tumor immunity, steroid receptors, cystic fibroses, and more.Key Features• It provides an excellent overview on a series of topics on gene therapy for the serious investigator

Advances in Agronomy

Water Renovation and Reuse focuses on the general principles and technological developments of water reuse and renovation. This book provides documented case studies of reuse practices and experiences throughout the world. Organized into two parts encompassing 15 chapters, this book starts with an overview of the different aspects of the problem to conserve, reuse, and recycle the limited water resources. This text proceeds to discuss the initial phase of water renovation and reuse, which is based on the conservationists'concept that society's wastes should be utilized and conserved to preserve the fertility of the soil. Other chapters explore the second phase of water renovation and reuse, which is motivated by the need to conserve and reuse water in arid areas. This book discusses as well the policy of zero pollution in the United States, which led to programs of land disposal. This book is intended for biologists, engineers, chemists, agronomists, public health officers, and water resources authorities.

International Review of Neurobiology

Current Topics in Developmental Biology, Volume 29 surveys the major issues at the forefront of developmental biology. This volume, like others in the serial, is valuable to researchers in the fields of animal and plant development, and to students and other professionals who want an introduction to current topics in cellular and molecular approaches to developmental biology. Volume 29s chapters on the nervous system, reproductive system, and flowering introduce new models and concepts for understanding these processes.Essential reading for anyone interested in: - Development of the nervous system - Development of the reproductive system - Flowering in plants - Roles of homeobox-related transcription factors, and growth factors in axis and organ development

International Review of Cytology

Chemical and Biological Generation of Excited States discusses major aspects of chemical and biological generation of electronic excitation. This book is organized into 11 chapters that focus on both chemi- and bioenergized processes. This book first discusses some of the fundamental aspects of the description of excited state behavior in condensed media. It then examines the field of gas-phase dioxetane chemiluminescence both by itself and in relation to solution-phase studies. The presented analysis is based on statistical mechanics and supported by a very simple limiting case calculation. Chapter 4 describes the state-of-the-art of how excitation yields are determined experimentally in chemienergized processes. This is followed by a discussion on activation parameters and stability trends, focusing on solution-phase data. Chapters 6 and 7 examine solution-phase chemiluminescence resulting from high-energy electron-transfer reaction, often involving aromatic radical ions, and the mechanism of excitation step. The next chapters cover the generation of electronic excited states in bioluminescence and the evaluation of luminescent oxidation mechanisms using oxygen tracers. The chapters also explain the formation of electronically excited products in dark biological processes and the mechanism of chemiexcitation as it relates to redox metabolism. Specific examples of biological oxygenation reactions yielding luminescence are also presented. Furthermore, this book discusses the concept and applicability of chemiluminigenic probing for the quantification and differentiation of oxygenation activities in mammalian phagocytes. The concluding chapter is devoted to the possible formation of singlet oxygen in various systems and processes that mimic singlet oxygen reactions. The book intends to attract young scientists as well as established research workers to broaden the horizons of this rapidly growing and potentially very important field.