Search

Your search keyword '"Cystadenoma ultrastructure"' showing total 4 results
Start Over Descriptor "Cystadenoma ultrastructure" Publisher academic press
4 results on '"Cystadenoma ultrastructure"'

3. Characterization of a hormone-producing ovarian carcinoma cell line.

Author

Poels LG, Jap PH, Ramaekers FF, Scheres JM, Thomas CM, Vooijs PG, Croes HJ, and Mungyer G

Subjects
Adult, Animals, Chromosome Aberrations, Cystadenoma genetics, Cystadenoma ultrastructure, Female, Humans, Immunohistochemistry, Keratins analysis, Mice, Mice, Inbred BALB C, Neoplasm Transplantation, Ovarian Neoplasms genetics, Ovarian Neoplasms ultrastructure, Transplantation, Heterologous, Tumor Cells, Cultured, Cystadenoma pathology, Estradiol biosynthesis, Ovarian Neoplasms pathology
Abstract

An ovarian carcinoma cell line (OTN 11) was produced from the ascitic fluid of a patient with a moderately to well differentiated papilliferous cystadenocarcinoma of the ovary. The cell line was characterized using electron microscopy karyotyping, immunohistochemical techniques with monoclonal antibodies against keratins as epithelial markers, and the monoclonal antibodies OV-TL 3 and OC 125 as ovarian carcinoma markers. These techniques revealed the epithelial and adenocarcinomatous nature of the cell line and the presence of ovarian carcinoma-related surface markers. The adenocarcinomatous nature of the cell line also became apparent after heterotransplantation of cell suspensions into nude mice and nude rats, in which adenomatous tumor structures were formed. These xenografts had the same ultrastructural and immunohistochemical properties as the cell line. Despite the adenocarcinomatous character of the tumor the cultured cells release estradiol into the culture medium. We may conclude that OTN 11 is an ovarian carcinoma cell line which has retained highly differentiated functions, such as the production of an ovarian hormone.

Published
1989
Full Text
View/download PDF

4. Serous tumors of the ovary. I. Ultrastructural and histochemical studies of the epithelium of the benign serous neoplasms, serous cystadenoma and serous cystadenofibroma.

Author

Fenoglio CM, Castadot MJ, Ferenczy A, Cottral GA, and Richart RM

Subjects
Adenofibroma etiology, Adenofibroma metabolism, Cystadenoma etiology, Cystadenoma metabolism, Epithelium ultrastructure, Female, Glycosaminoglycans metabolism, Humans, Microscopy, Electron, Microvilli ultrastructure, Ovarian Neoplasms etiology, Ovarian Neoplasms metabolism, Adenofibroma ultrastructure, Cystadenoma ultrastructure, Ovarian Neoplasms ultrastructure
Published
1977
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results