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Advances in Host Genetics and Microbiome in Colorectal Cancer-Related Phenotypes, Volume 112 in the Advances in Genetics series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as What we need in colorectal cancer research, and why?, Host Genetics and Microbiota procedures in colorectal cancer research, Host Genetics-associated mechanisms in colorectal cancer, Microbiota-associated mechanisms in colorectal cancer, Inflammation regulation in colorectal cancer, Microbiota and detrimental protein metabolites in colorectal cancer, Microbiota and other detrimental metabolites in colorectal cancer, Microbiota and beneficial metabolites in colorectal cancer, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Genetics series - Includes the latest information on new advancements in the study of genetics

Foot and Ankle Biomechanics is a one source, comprehensive and modern reference regarding foot and ankle biomechanics. This text serves as both a master reference for foot biomechanics, presenting a clear state of the research and capabilities in the field. The customers for this book will be those looking for information on foot and ankle biomechanics for a range of applications; for example, designers of orthotics. - Provides a comprehensive overview of the science of foot and ankle biomechanics that is presented in an easily accessible format - Presents normative data and descriptions relating to the structure and function of the foot and ankle, along with comparisons to pathological conditions - Includes multimedia content to support modeling and simulation chapters

This completely updated and expanded 2nd edition of Systemic Lupus Erythematosus, A Manual includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter is short and is presented critically with selected references, which should be valuable to a wider audience. This book combines basic with clinical science to help internists and specialists in the diagnosis and management of patients with SLE. It is a quick referral for people in the pharmaceutical industry in their efforts to bring much-needed drugs. It provides all the needed information to basic researchers old and new alike, who wish to enter the field of lupus and systemic autoimmunity in general. - Focused state-of-the-art chapters prepared by top-notch experts in the field - Latest understanding of cellular, molecular, biochemical aspects of disease pathogenesis - Advanced aspects of genetic, microbiome, environmental, hormonal, and immunological contribution to the expression of the disease - Current understanding of clinical features of the disease - Recent efforts to develop new treatments

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. - Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations - Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics - Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

Data Processing Handbook for Complex Biological Data provides relevant and to the point content for those who need to understand the different types of biological data and the techniques to process and interpret them. The book includes feedback the editor received from students studying at both undergraduate and graduate levels, and from her peers. In order to succeed in data processing for biological data sources, it is necessary to master the type of data and general methods and tools for modern data processing. For instance, many labs follow the path of interdisciplinary studies and get their data validated by several methods. Researchers at those labs may not perform all the techniques themselves, but either in collaboration or through outsourcing, they make use of a range of them, because, in the absence of cross validation using different techniques, the chances for acceptance of an article for publication in high profile journals is weakened. - Explains how to interpret enormous amounts of data generated using several experimental approaches in simple terms, thus relating biology and physics at the atomic level - Presents sample data files and explains the usage of equations and web servers cited in research articles to extract useful information from their own biological data - Discusses, in detail, raw data files, data processing strategies, and the web based sources relevant for data processing

Systemic Lupus Erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. - Provides the very latest overview of the pathogenesis of SLE - Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease - Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more - Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage - Discusses the latest treatment options on disease modifying or disease controlling agents - Provides'one stop'coverage of all the latest scientific and clinical developments in SLE

Stiehm's Immune Deficiencies focuses on immunodeficiencies in children and adults. This book covers the many advances in the study of immunodeficiency. Stiehm's Immune Deficiencies includes 62 chapters covering topics such as newly described syndromes, genetic diagnosis, molecular abnormalities, newborn screening, and current therapies. - Provides practical guidance to practitioners dealing with the day-to-day issues of diagnosis and management of immune deficient patients - Covers both clinical management and scientific advances in one place - Includes newly described disorders in various periodic updates to maintain the breadth of the reference