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Foodborne and Microorganisms: Spoilage and Pathogens and their Control, Volume 110 in the Advances in Food and Nutrition Research series, updates on the latest developments in this evolving science. Chapters in this new release include Understanding the potential of fresh produce as vehicles of Salmonella enterica, Modeling and Optimization of Non-thermal Technologies for Animal-origin Food Decontamination, Space food production on safety and quality: Hazard Analysis and Critical Control Points (HACCP) plan and quality control methods, Inactivation of foodborne pathogens by nonthermal Technologies, Foodborne sporeforming bacteria: challenges and opportunities for their control through food production chain, and more.Additional sections focus on Spoilage microorganisms in the dairy industry, Foodborne pathogens in the pork production chain, Food spoilage fungi: main sources and controlling strategies, Advanced data analytics and'omics'techniques to control enteric foodborne pathogens, and Prevention of foodborne virus and pathogens in fresh produce and root vegetables. - Key features of key microorganisms causing food spoilage and of relevance for food safety - Focus on intervention/ controlling strategies to avoid microbiological food safety and to ensure food safety - New insights into management tools and omics for studying foodborne microorganisms

Microbial Biostimulants for Plant Growth, Development and Abiotic Stress Amelioration provides readers with insights into the major role of biostimulants in plant growth and development while under abiotic stress. The term biostimulants is broadly used to reference a group of diverse substances and microorganisms that stimulate life or that promote favorable plant responses. They stimulate natural processes to enhance/benefit nutrient uptake, nutrient efficiency, tolerance to abiotic stress, and crop quality. Many biostimulants improve nutrition and they do so regardless of their own nutrient contents. Further, recently microbe-based biostimulants have emerged as important plant protectors under a range of adverse conditions. Microbial Biostimulants for Plant Growth, Development and Abiotic Stress Amelioration is the latest volume in the Biostimulants and Protective Biochemical Agents series. - Presents the potential for more environmentally sustainable interventions against abiotic stresses - Highlights the variety of applications for which biostimulants are proving effective - Includes coverage of commercialization and role in addressing Sustainability Development Goals

Sustainable Agriculture under Drought Stress: Integrated Soil, Water and Nutrient Management seamlessly blends cutting-edge research with practical applications, offering a unique perspective on tackling this urgent challenge. Through a multidisciplinary lens, this book provides a cohesive and comprehensive understanding of both the current landscape and future prospects. Readers will find this book equips them with the knowledge and strategies required to manage soil nutrients and water effectively, ensuring the health of both soil and plants, especially in arid and semi-arid regions, where solutions are urgently needed. This book offers actionable insights into mitigating the impacts of climate change on agricultural systems, making it essential reading for anyone invested in sustainable land management and food security. - Clarifies mechanisms and proposes solutions for enhancing soil health and fertility, irrigation management, and crop production in drought-stressed environments - Presents a diverse array of options for responding to drought stress, optimizing plant health and furthering sustainability - Explores emerging cropping systems and opportunities

Advances in Agronomy, Volume 180, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Chapters in this new release include The Socio-Economic Impact of Fungicide Resistance in West Australia's Wheatbelt, Microbial Inoculant Carriers: Soil Health Improvement and Moisture Retention in Sustainable Agriculture, Response Network of Plant-Soil-Rhizosphere Environment to Drought Stress and their Regulatory Measures, and Agricultural Residues Management: Life Cycle Assessment Implications for Sustainable Agricultural Practices and Reduction of Greenhouse Gases Emissions, An Analysis of Earth Temperature and Related Series in Air and Soil. - Includes numerous, timely, state-of-the-art reviews on the latest advancements in agronomy - Features distinguished, well recognized authors from around the world - Builds upon this venerable and iconic review series - Covers the extensive variety and breadth of subject matter in the crop and soil sciences

Rhizosphere Engineering is a guide to applying environmentally sound agronomic practices to improve crop yield while also protecting soil resources. Focusing on the potential and positive impacts of appropriate practices, the book includes the use of beneficial microbes, nanotechnology and metagenomics. Developing and applying techniques that not only enhance yield, but also restore the quality of soil and water using beneficial microbes such as Bacillus, Pseudomonas, vesicular-arbuscular mycorrhiza (VAM) fungi and others are covered, along with new information on utilizing nanotechnology, quorum sensing and other technologies to further advance the science. Designed to fill the gap between research and application, this book is written for advanced students, researchers and those seeking real-world insights for improving agricultural production. - Explores the potential benefits of optimized rhizosphere - Includes metagenomics and their emerging importance - Presents insights into the use of biosurfactants

Handbook of Opium: History and Basis of Opioids in Therapeutics traces the history of poppy from its prehistory, its use in Greek and Egyptian medicine through the European Renaissance, and the opioid epidemic of the present day. The book explores the discovery of morphine and its alkaloids, reviews its biosynthetic process, and covers the evolution of synthetic opioids. Further, it reviews the biological effects of opium and the molecular basis of its actions, including future perspectives in clinical applications with therapeutic targets. The book is interspersed with numerous notes on the events and great minds in history and medicine who advocated, analyzed and advanced opium through history. The book is a comprehensive review on opium, covering a breadth of topics, including its history, botany, chemistry, trade, physiology, clinical use and molecular biology, with numerous references, tables, vignettes and illustrations included for additional understanding. - Presents a comprehensive review on opium, covering a range of topics - Filled with historical vignettes, tables and illustrations to aid understanding - Authored by practicing clinicians who integrate clinical information in the context of history and pharmacology

Treatise on Geomorphology, Second Edition, Eleven Volume Set is organized into eleven volumes built on the outstanding success of the first edition. This comprehensive introduction to the large and diverse discipline of geomorphology provides a key reference tool for undergraduate geology students looking for term paper topics, graduate students starting a literature review for their thesis work, and for professionals seeking a concise summary of a particular topic. The tools available to understand geomorphology have greatly advanced in recent years, hence this new release will complement the work of a variety of professionals who are interested in topics such as GIScience, Remote Sensing and Karst. - Authoritative, authored and edited by recognized experts in the field, with a range of different expertise that ensures a high-quality standard for all chapters - Provides up-to-date information in a field that has seen significant progress in past years, including key advances in Remote Sensing and GIScience - Offers users a'one-stop', comprehensive resource for access to a wealth of information and critical summaries, thus bridging the gap between different specialties

The microbial ecosystem provides an indigenous system for improving plant growth, health and stress resilience. Plant microbiota, including isolated microbial communities, have been studied to further understand the functional capacities, ecological structure and dynamics of the plant-microbe interaction. Due to climatic changes, there is an urgent need to bring microbial innovations into practice. Mitigation of Plant Abiotic Stress by Microorganisms: Applicability and Future Directions is a comprehensive review of the different strategies available to improve the plant microbiome. Chapters include key topics such as: harnessing endophytic microbial diversity, microbial genes for improving abiotic stress tolerance, and microbial bioformulations. Putting these strategies into practice can have varying success in the field, so it is crucial that scientists are equipped with the knowledge of which microorganisms are needed, as well as the use and suitability of delivery approaches and formulations. This title will be an essential read for researchers and students interested in plant microbial technologies and plant bio stimulants, plant pathology, biocontrol, agronomy, and environmental mediation. - Discusses adaptive mechanisms of plant against multiple stresses - Highlights diversity of symbiotic microorganisms associated with insects and their impact on host plants - Provides functional genomics tools for studying microbe-mediated stress tolerance

Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics is an essential read for anyone working in pain management. The book addresses the onset of pain, the cause of the pain, and the administration of analgesia or anesthesia. The etiology of pain is complex and multi-factorial, which is made more complex with the use of analgesics and local or general anesthetics. This volume works to clarify all of the subjects pertinent to anesthesia and the brain, from their variety, modes of action, and adverse effects. - Provides a broad range of topics related to the neuroscience of analgesics and anesthetics - Contains chapter abstracts, key facts, a dictionary of terms, and summary points to aid in understanding - Discusses anesthesia types, mechanisms of action and affiliated effects - Helps readers navigate key areas for research and further clinical recommendations

The Neuroscience of Pain, Anesthetics and Analgesics examines the syndromes of pain and how they interlink with anesthesia and analgesics. The book covers assessments, screening and resources, and provides applications to related areas of medicine. It explores how the perception of pain results from a multifaceted interaction between illness beliefs, age, gender, time of onset, stress, socioeconomic status, and other factors. In addition, it scrutinizes how the neuroscience of pain in one condition may be relevant to understanding pain observed in other conditions. Sections address the onset of pain, the cause of pain, and the administration of analgesia or anesthesia. The book works to clarify all of the subjects pertinent to anesthesia and the brain. Featuring chapters on neurotransmitters, pharmacology and brain imaging, this volume discusses the mechanisms of pain and experimental studies undertaken to better understand the pathways involved. - Includes content on the features and assessments of pain, anesthesia and analgesia - Provides a mini-dictionary of terms and summary points that succinctly encapsulate each chapter - Covers a broad range of topics related to the neuroscience of analgesics and anesthetics - Helps readers navigate key areas for research and further clinical recommendations - Features chapters on molecular pathways, imaging and a deep look at behavior associated with the experience of pain

Advances in Applied Microbiology, Volume 115 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology, with this release focusing on the preparation of functional oligosaccharides using microbial coupling fermentation. - Contains contributions from leading authorities in the field - Informs and updates on the latest developments in the field of microbiology - Includes discussions on the role of specific molecules in pathogen life stages, interactions, and much more

Neurobiology of Addiction and Comorbid Disorders, Volume 156, in the International Review of Neurobiology series, highlights new advances in the field of neurobiology, with this new volume presenting interesting chapters on topics such as Pain + Alcohol, Pain + Opioids, Traumatic Stress + Alcohol, Traumatic Stress + Cannabinoids, Traumatic Brain Injury and the Misuse of Alcohol, Opioids, and Cannabis, Depression + Addiction, Microbiome/cytokines + Addiction, Cognitive disorders + Alcohol, Neural stem cells, Neurogenesis and Addiction, Food Addiction, and Poly-drug Addiction. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Neurobiology series - Updated release includes the latest information on the Neurobiology of Addiction and Co-Morbid Disorders

Advances in Agronomy, Volume 169, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors. - Includes numerous, timely, state-of-the-art reviews on the latest advancements in agronomy - Features distinguished, well recognized authors from around the world - Builds upon this venerable and iconic review series - Covers the extensive variety and breadth of subject matter in the crop and soil sciences

The Senses: A Comprehensive Reference, Second Edition, Seven Volume Set is a comprehensive reference work covering the range of topics that constitute current knowledge of the neural mechanisms underlying the different senses. This important work provides the most up-to-date, cutting-edge, comprehensive reference combining volumes on all major sensory modalities in one set. Offering 264 chapters from a distinguished team of international experts, The Senses lays out current knowledge on the anatomy, physiology, and molecular biology of sensory organs, in a collection of comprehensive chapters spanning 4 volumes. Topics covered include the perception, psychophysics, and higher order processing of sensory information, as well as disorders and new diagnostic and treatment methods. Written for a wide audience, this reference work provides students, scholars, medical doctors, as well as anyone interested in neuroscience, a comprehensive overview of the knowledge accumulated on the function of sense organs, sensory systems, and how the brain processes sensory input. As with the first edition, contributions from leading scholars from around the world will ensure The Senses offers a truly international portrait of sensory physiology. The set is the definitive reference on sensory neuroscience and provides the ultimate entry point into the review and original literature in Sensory Neuroscience enabling students and scientists to delve into the subject and deepen their knowledge. - All-inclusive coverage of topics: updated edition offers readers the only current reference available covering neurobiology, physiology, anatomy, and molecular biology of sense organs and the processing of sensory information in the brain - Authoritative content: world-leading contributors provide readers with a reputable, dynamic and authoritative account of the topics under discussion - Comprehensive-style content: in-depth, complex coverage of topics offers students at upper undergraduate level and above full insight into topics under discussion

Food Quality and Shelf Life covers all aspects and challenges of food preservation, packaging and shelf-life. It provides information on the most important pillars in the field, starting with active and smart packaging materials, novel technologies, and control tools in all stages between production and consumer. The book gives emphasis to methodological approaches for sensory shelf-life estimation and the impact of packaging on sensorial properties. Researchers and professionals alike will find this reference useful, especially those who are interested in the performance evaluation of future packaging for fresh produce in the cold chain and temperature management in the supply chain. - Presents insights regarding new trends in emerging technologies in the field - Includes hot topics, such as modified atmosphere packaging and active materials to improve shelf-life - Provides shelf-life assessment and modeling methodologies and accelerated shelf-life testing

Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract. As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students. - Discusses the multiple processes governing gastrointestinal function - Presents new information on the brain-gut axis and microbiome - Edited by preeminent scientists in the field - Includes coverage of issues, such as food allergies, constipation, chronic liver disease, IBS, Crohn's disease, and more

Innovative Technologies for Food Preservation: Inactivation of Spoilage and Pathogenic Microorganisms covers the latest advances in non-thermal processing, including mechanical processes (such as high pressure processing, high pressure homogenization, high hydrodynamic pressure processing, pressurized fluids); electromagnetic technologies (like pulsed electric fields, high voltage electrical discharges, Ohmic heating, chemical electrolysis, microwaves, radiofrequency, cold plasma, UV-light); acoustic technologies (ultrasound, shockwaves); innovative chemical processing technologies (ozone, chlorine dioxide, electrolysis, oxidized water) and others like membrane filtration and dense phase CO2. The title also focuses on understanding the effects of such processing technologies on inactivation of the most relevant pathogenic and spoilage microorganisms to ensure food safety and stability. Over the course of the 20th century, the interest and demand for the development and application of new food preservation methods has increased significantly. The research in the last 50 years has produced various innovative food processing technologies and the use of new technologies for inactivation of spoilage and/or pathogenic microorganisms will depend on several factors. At this stage of development there is a need to better understand the mechanisms that govern microbial inactivation as induced by new and innovative processing technologies, as well as suitable and effective conditions for inactivating the microorganism. - Serves as a summary of relevant spoilage and pathogenic microorganisms for different foods as influenced by the application of innovative technologies for their preservation - Provides readers with an in-depth understanding on how effective innovative processing technologies are for controlling spoilage and pathogenic microorganisms in different foods - Integrates concepts in order to find the optimum conditions for microbial inactivation and preservation of major and minor food compounds

Modern Techniques for Food Authentication, Second Edition presents a comprehensive review of the novel techniques available to authenticate food products, including various spectroscopic technologies, methods based on isotopic analysis and chromatography, and other techniques based on DNA, enzymatic analysis and electrophoresis. This new edition pinpoints research and development trends for those working in research, development and operations in the food industry, giving them readily accessible information on modern food authentication techniques to ensure a safe and authentic food supply. It will also serve as an essential reference source to undergraduate and postgraduate students, and for researchers in universities and research institutions. - Presents emerging imaging techniques that have proven to be powerful, non-destructive tools for food authentication - Includes applications of hyperspectral imaging to reflect the current trend of developments in food imaging technology for each topic area - Provides pixel level visualization techniques needed for fast and effective food sample testing - Contains two new chapters on Imaging Spectroscopic Techniques

Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. - Comprehensive set of critical reviews covering the field - Presents state-of-the-art topics in science and translational medicine - Written by international leaders in the field of neural transplantation

Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. - Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications - Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system - Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine

Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers “General Considerations” and Volume II is devoted to “Specific Metals.” A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals. Contains 61 peer reviewed chapters dealing with the effects of metallic elements and their compounds on biological systems Includes information on sources, transport and transformation of metals in the environment and on certain aspects of the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health Covers the toxicology of metallic nanomaterials in a new comprehensive chapter Metal toxicology in developing countries is dealt with in another new chapter emphasizing the adverse effects on human health by the inadequate handling of'ewaste” Other new chapters in the 4th edition include: Toxic metals in food; Toxicity of metals released from medical devices; Gene-environment interactions; Neurotoxicology of metals; Cardiovascular disease; Renal effects of exposure to metals; Gold and gold mining; Iridium; Lanthanum; Lithium and Rhodium

The second edition of Emerging Technologies in Food Processing presents essential, authoritative, and complete literature and research data from the past ten years. It is a complete resource offering the latest technological innovations in food processing today, and includes vital information in research and development for the food processing industry. It covers the latest advances in non-thermal processing including high pressure, pulsed electric fields, radiofrequency, high intensity pulsed light, ultrasound, irradiation, and addresses the newest hurdles in technology where extensive research has been carried out. - Provides an extensive list of research sources to further research development - Presents current and thorough research results and critical reviews - Includes the most recent technologies used for shelf life extension, bioprocessing simulation and optimization

The changing focus and approach of geomorphic research suggests that the time is opportune for a summary of the state of discipline. The number of peer-reviewed papers published in geomorphic journals has grown steadily for more than two decades and, more importantly, the diversity of authors with respect to geographic location and disciplinary background (geography, geology, ecology, civil engineering, computer science, geographic information science, and others) has expanded dramatically. As more good minds are drawn to geomorphology, and the breadth of the peer-reviewed literature grows, an effective summary of contemporary geomorphic knowledge becomes increasingly difficult. The fourteen volumes of this Treatise on Geomorphology will provide an important reference for users from undergraduate students looking for term paper topics, to graduate students starting a literature review for their thesis work, and professionals seeking a concise summary of a particular topic. Information on the historical development of diverse topics within geomorphology provides context for ongoing research; discussion of research strategies, equipment, and field methods, laboratory experiments, and numerical simulations reflect the multiple approaches to understanding Earth's surfaces; and summaries of outstanding research questions highlight future challenges and suggest productive new avenues for research. Our future ability to adapt to geomorphic changes in the critical zone very much hinges upon how well landform scientists comprehend the dynamics of Earth's diverse surfaces. This Treatise on Geomorphology provides a useful synthesis of the state of the discipline, as well as highlighting productive research directions, that Educators and students/researchers will find useful. - Geomorphology has advanced greatly in the last 10 years to become a very interdisciplinary field. Undergraduate students looking for term paper topics, to graduate students starting a literature review for their thesis work, and professionals seeking a concise summary of a particular topic will find the answers they need in this broad reference work which has been designed and written to accommodate their diverse backgrounds and levels of understanding - Editor-in-Chief, Prof. J. F. Shroder of the University of Nebraska at Omaha, is past president of the QG&G section of the Geological Society of America and present Trustee of the GSA Foundation, while being well respected in the geomorphology research community and having won numerous awards in the field. A host of noted international geomorphologists have contributed state-of-the-art chapters to the work. Readers can be guaranteed that every chapter in this extensive work has been critically reviewed for consistency and accuracy by the World expert Volume Editors and by the Editor-in-Chief himself - No other reference work exists in the area of Geomorphology that offers the breadth and depth of information contained in this 14-volume masterpiece. From the foundations and history of geomorphology through to geomorphological innovations and computer modelling, and the past and future states of landform science, no'stone'has been left unturned!

New discoveries in the field of stem cells increasingly dominate the news and scientific literature revealing an avalanche of new knowledge and research tools that are producing therapies for cancer, heart disease, diabetes, and a wide variety of other diseases that afflict humanity. The Handbook of Stem Cells integrates this exciting area of life science, combining in two volumes the requisites for a general understanding of adult and embryonic stem cells. Organized in two volumes entitled Pluripotent Stem Cells and Cell Biology and Adult and Fetal Stem Cells, this work contains contributions from the world's experts in stem cell research to provide a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations as well as a the latest information of what is known about each specific organ system. - Provides comprehensive coverage on this highly topical subject - Contains contributions by the foremost authorities and premiere names in the field of stem cell research - Companion website - http://booksite.elsevier.com/9780123859426/ - contains over 250 color figures in presentation format

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure.• Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology• The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine• New discoveries from leading researchers on restoration of diseased tissues and organs

There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. - Provides detailed description of clinical trials in cell transplantation - Review of current therapeutic approaches - Coverage of the broad range of diseases addressed by cell therapeutics - Discussion of stem cell biology and its role in transplantation

Advances in Heat Transfer fills the information gap between regularly scheduled journals and university-level textbooks by providing wide-ranging and in-depth review articles. Put simply, this book is essential reading for all mechanical, chemical and industrial engineers working in the field of heat transfer in graduate schools or industry. The articles, which serve as a broad review for experts in the field, will also be of great interest to non-specialists who need to keep up-to-date with the results of the latest research. - Provides an overview of review articles on topics of current interest - Bridges the gap between academic researchers and practitioners in industry - A long-running and prestigious series

The purpose of the book is to bring together in one place the different facets of regenerative biology and medicine while providing the reader with an overview of the basic and clinically-oriented research that is being done. Not only does the content cover a plethora tissues and systems, it also includes information about the developmental plasticity of adult stem cells and the regeneration of appendages.As part of its balanced presentation, Regenerative Biology and Medicine does address the biological/bioethical issues and challanges involved in the new and exciting field of regenerative biology and medicine.•Tissues covered include skin, hair, teeth, cornea, and central neural types•Systems presented are digestive, respiratory, urogenital, musculoskeletal, and cardiovascular•Includes amphibians as powerful research models•Discusses appendage regeneration in amphibians and mammals

This is the second of three planned volumes in the Methods in Enzymology series on the topic of stem cells. This volume is a unique anthology of stem cell techniques focusing on adult stem cells, and written by experts from the top laboratories in the world. The contributors not only have hands-on experience in the field but often have developed the original approaches that they share with great attention to detail. The chapters provide a brief review of each field followed by a'cookbook and handy illustrations. The collection of protocols includes the isolation and maintenance of stem cells from various species using'conventional and novel methods, such as derivation of ES cells from single blastomeres, differentiation of stem cells into specific tissue types, isolation and maintenance of somatic stem cells, stem cell-specific techniques and approaches to tissue engineering using stem cell derivatives. The reader will find that some of the topics are covered by more than one group of authors and complement each other. Comprehensive step-by-step protocols and informative illustrations can be easily followed by even the least experienced researchers in the field, and allow the setup and troubleshooting of these state-of-the-art technologies in other laboratories. - Provides complete coverage spanning from derivation/isolation of stem cells, and including differentiation protocols, characterization and maintenance of derivatives and tissue engineering - Presents the latest most innovative technologies - Addresses therapeutic relevance including FDA compliance and tissue engineering

Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology. Volume 67, covers innovative topics such as Control of Food-intake through Regulation of camp, regeneration of deer antlers, factors affecting male song evolution in drosophila montana, skeletal stem cells in regenerative medicine, and so much more. - Contains 10 vital contributions from leading minds in developmental biology - Presents an analysis of contemporary topics such as regeneration of stem cells, drosophila montana, and programmed cell death in plants - Offers 17 full color figures in detail of the chapters

New discoveries in the field of stem cell research have frequently appeared in the news and in scientific literature. Research in this area promises to lead to new therapies for cancer, heart disease, diabetes, and a wide variety of other diseases. This two-volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system. The editors of the Handbook of Stem Cells include: Robert Lanza, Helen Blau, John Gearhart, Brigid Hogan, Douglas Melton, Malcolm Moore, Roger Pedersen, E. Donnall Thomas, James Thomson, Catherine Verfaillie, Irving Weissman, and Michael West. The Editorial Board includes: W. French Anderson, Peter Andrews, Anthony Atala, Jose Cibelli, Giulio Cossu, Robert Edwards, Martin Evans, Elaine Fuchs, Margaret Fuller, Fred Gage, Richard Gardner, Margaret Goodell, Ronald Green, William Haseltine, Joseph Itskovitz-Eldor, Rudolf Jaenisch, Ihor Lemischka, Dame Anne McLaren, Richard Mulligan, Stuart Orkin, Martin Pera, Benjamin Reubinoff, Janet Rossant, Hans Scholer, Austin Smith, Evan Snyder, Davor Solter, Alan Trounson, and Leonard Zon.This comprehensive set should be a much-needed addition to the library of students and researchers alike.• Provides comprehensive coverage on this highly topical subject• Contains contributions by the foremost authorities and premiere names in the field of stem cell research• The accompanying CD-ROM includes over 250 color figures

Tay-Sachs disease is a rare hereditary disease caused by a genetic mutation that leaves the body unable to produce an enzyme necessary for fat metabolism in nerve cells, producing central nervous system degeneration. In infants, it is characterized by progressive mental deterioration, blindness, paralysis, epileptic seizures, and death by age four. Adult-onset Tay-Sachs occurs in persons who have a genetic mutation that is similar but allows some production of the missing enzyme. There is no treatment for Tay-Sachs.A test to determine whether an infant is carrying the Tay-Sachs disease was introduced in 1969. However, work continues to be done to help find a cure. Because there is no cure for this deadly disease, genetic research is essential. Advances in Genetics presents an eclectic mix of articles of use to all human and molecular geneticists. They are written and edited by recognized leaders in the field and make this an essential series of books for anyone in the genetics field.

CNS Regeneration focuses on some of the leading current neurological disease models and methods for promoting central nervous system regeneration. Editors and authors are experts in the field, with experience in basic as well as applied neuroscience. In a comprehensive, logical manner, the book unites important basic science advances in neuroscience with novel medical strategies. - The first comprehensive, authoritative volume on the topic of CNS regeneration - Reviews current therapeutic approaches - Editors and authors are experts in the field - Appeals to those interested in basic science as well as those concerned with its medical application