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Technological Advances and Innovations in the Treatment of Chronic Respiratory Disorders focuses on 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modeling. The book, written by a team of leading experts in the field, is an essential resource for anyone interested in the future of CRD treatment. Chapters discuss the emerging therapeutic approaches for CRDs, including biologicals and phytoceuticals. Core chapters of the book then cover the application of 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modeling to different CRDs. The book concludes with a discussion of the current clinical trials and future prospects for the management of CRDs.This is a valuable resource for researchers, clinicians, and other healthcare professionals who are interested in the latest technological advances in the field of CRDs. It will also be of interest to students and scientists working in the fields of pharmaceutical sciences, microfluidics, bioinformatics, drug design, drug delivery, and 3D printing. - Provides the most recent and updated perspectives and challenges in the management of chronic respiratory disorders - Covers exciting new technologies such as 3D printing, bioprinting, microfluidics, organ-on-a-chip systems, and molecular modelling - Includes the most recent information on the development of advanced drug delivery systems for the treatment of chronic respiratory disorders

Lung size, function and health: Reappraising the epidemiology of chronic lung disease in adults proposes an alternative perspective to the current dominant explanations for the distribution of chronic lung disease. This book considers the link between chronic respiratory disease and associated mortality with smaller lungs rather than obstructed airways, and explores other factors contributing to poor lung health besides the current emphasis on the roles of air pollution, occupational exposures, and cardio-metabolic disease. It presents the findings of the Burden of Obstructive Lung Disease (BOLD) study, sharing new views on the prevalence of obstructive lung disease and its risk factors across various regions in the world. Lung Size, Function and Health: Reappraising the Epidemiology of Chronic Lung Disease in Adults explores a variety of factors surrounding decreased lung function, including the prevalent views on the impact of both household and external air pollution, occupational exposure, and the prenatal and postnatal/childhood environment in the etiology of impaired lung function and COPD. It then moves on to discussion of the impact poverty and nutrition has on lung health, sharing the findings of the BOLD study regarding its effect on lung function and risk of COPD in lower-income countries. The book closes with a chapter outlining the clinical and public health implications of the findings discussed in the book. This concise volume provides novel insights into the causes of lung impairment and sets a new precedent for future research into potential treatments, making it an ideal resource for those working in the area of respiratory medicine and related fields. - Evaluates the role of environmental and lifestyle risk factors in lung health and disease, including pollution, occupational exposures, early infection in childhood, poverty, and diet - Provides new perspectives on the significance of low lung volumes vs. chronic airflow obstruction, considering lower adult lung function as a predictor of poorer respiratory health, mortality, and potential comorbidities - Shares findings from the international Burden of Obstructive Lung Disease (BOLD) study, including analysis in low-income countries

Advances in Immunology, Volume 158, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. - Presents current developments and comprehensive reviews in immunology - Provides the latest in a longstanding and respected serial on the subject matter - Focuses on recent advances in t cells and HIV infection

Adenosine A2A Receptor Antagonists, Volume 170 in the International Review of Neurobiology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including A2A Adenosine Receptor Agonists, Antagonists, Inverse Agonists and Partial Agonist, Chemistry – agonists, antagonists, partial agonists, inverse agonists, Functional roles of adenosine receptors – biochemistry and neuronal plasticity, A2A and Depression, A2AR and glial function, The adenosine A2A receptor in the basal ganglia: expression in health and disease, heteromerization, functional selectivity and signaling, How and why A2a receptor become to be a therapeutic target in Parkinson's disease therapy, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Neurobiology - Updated release includes the latest information on Adenosine A2A Receptor Antagonists

Pulmonary Pharmacology, Volume 98 provides in-depth reviews on the latest progresses about respiratory drug discovery and development. Topics covered in this volume include corticosteroids, monoclonal antibodies, tyrosine kinase inhibitors and phosphodiesterase inhibitors for the treatments of asthma, COPD or pulmonary fibrosis, with perspective on the development of novel therapeutic strategies such as renin-angiotensin system modulators, mitochondrial function modulators, and non-antibacterial macrolides. Part of the volume is devoted to senotherapy for lung ageing in respiratory diseases, and novel pulmonary delivery technologies, including inhaled biologics. - Provides accurate reviews from leading experts on the topic of pulmonary pharmacology - Each chapter of the volume provides consolidated graphical materials for ease of reading for the audience - Provides the latest insights and future perspectives on the drug discovery and development for respiratory diseases

The South African Herbal Pharmacopeia: Monographs of Medicinal and Aromatic Plants is a collection of 25 original monographs of medicinal plants that are currently under commercialization or have the potential for commercialization into herbal medicinal products for the global marketplace. Chapters include a general overview covering synonyms, common names, conservation status, botany, geographical distribution, ethnopharmacology, commercialization, pharmacological evaluation, chemical profiling and quality control, including HPTLC fingerprint analysis, UPLC analysis, gas chromatography and mid-infrared spectroscopy analysis. Academics researching pharmacy and analytical chemistry will benefit from the detailed chemical profile on each species presented. Industrial manufacturers of herbal products, herbal medicines, cosmetics, food supplements, and national and international policymakers and regulators will benefit from the overview provided at the beginning of each chapter. - Provides a comprehensive, up-to-date literature review on 25 medicinal plants of South Africa - Documents quality control protocols for chemical fingerprinting and biomarker identification in plant material - Includes updated safety profiles of medicinal plants

••Selected for Doody's Core Titles® 2024 in Allergy/Clinical Immunology••Allergic and Immunologic Diseases: A Practical Guide to the Evaluation, Diagnosis and Management of Allergic and Immunologic Diseases is a valuable resource for researchers and others involved in the day-to-day practice of allergy and immunology, with specific information, protocols and algorithms to guide their thinking. The book provides practical information and an explanation of why and how we do things, while also addressing the limitations of testing and treatment. Other sections focus on scientific based practices and the known pathophysiology of allergic and immunologic diseases, along with mechanisms of action in various treatment modalities. This book is unique in that it explains the rationale behind everything we do in allergy and immunology, hence it offers readers specific information on procedures and how to order tests and treat allergic and immunologic diseases. - Contains useful information on allergic and immunologic diseases, from why we do things the way we do, to methodologies, interpretation of the results and management of diseases - Provides information that can be immediately downloadable for any specific procedure or treatment algorithm for immediate use - Evaluates scientific merit and evidence or lack thereof

The reduction in nutritional quality of food due to microbial contamination is a problem faced by much of the developing world. To address contamination-related hunger and malnutrition, it is crucial to enforce quantitative and qualitative protection of agri-food commodities after harvesting, as well as to create low cost, rational strategies to protect post-harvest losses and nutritional properties of food products in a sustainable manner. Research and Technological Advances in Food Science provides readers with a systematic and in-depth understanding of basic and advanced concepts in food science and post-harvest technology, including the most up-to-date information about different natural food source sources (of microbial, plant, and animal origin) and their health benefits. It also highlights current research and technological advances in food science related to health, such as personalized food and nutrition, seafood nutraceuticals, meat processing and product development, microbial enzymes for the tenderization of meat, feruloylated oligosaccharides for human health, and the role of microbial antagonistic in post-harvest management of fruit. In addition, the book explores the role of modern tools and techniques such as instrumentation, nanotechnology, biotechnology, ultrasound in food processing and food-omics in food science. Research and Technological Advances in Food Science is an excellent resource for researchers, food scientists, biochemists, pharmacologists, nutritionists, policymakers, and students working in the food science domain. - Includes information about different natural sources of food (microbes, plants and animal origin), and their health benefits - Highlights current research and technological advances in food science related to health - Brings the role of microbial antagonistic, plant volatiles and technological advances in the post-harvest management of food commodities

Encyclopedia of Respiratory Medicine, Second Edition, Six Volume Set explores the key processes of lung diseases and their diagnosis and management. The book dissects the molecular and cellular biology, physiology and immunology that underpin normal lung function, along with the aberrations that occur in respiratory diseases, from common disorders such as asthma and COPD to rarer lung diseases such as cystic fibrosis, interstitial lung diseases and pulmonary hypertension. Written in at a time when the globe is in the grip of respiratory pandemic, lung disease has never been so prominent in the public and political conscious. This new edition will provide new researchers in respiratory medicine with a solid foundation in unfamiliar topics and will update more experienced researchers seeking to step outside their core areas of research to put their work into a broader context. - Presents a'one-stop'resource covering the entire scope of modern respiratory medicine - Brings together a truly global collaboration of some of the most authoritative voices in respiratory medicine - Provides chapters that are concise and accessible, with an authoritative introduction for non-specialists, as well as up-to-date, foundational content for those familiar with the field - Includes multimedia-rich content, including hundreds of clear and helpful illustrations that can be used as teaching aids

In recent years, researchers around the globe have deep dived into the fascination world of the Macrophage and its diverse role in tissue development, angiogenesis, and wound healing, and above all the untapped mystery of the wondering immune system within our body. Macrophages and their role in inflammation includes all the latest information of macrophages and inflammation as well as it provides an in-depth understanding of this complex and rapidly progressing field of study. - Outlines the role of macrophages in inflammation - Contains chapters by leading authors on the basic and translational aspects of macrophage biology - Deals with internal and external treats

Advances in Genetics, Volume 107, provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, with this new release including chapters on Advances in Asthma Genetics: Filling persistent gaps, Nutritional control of postembryonic development progression and arrest in Caenorhabditis elegans, Genetic determinants of climate-resilience traits in millets, Founder variants and population genomes - towards precision medicine, and much more. - Critically analyzes future directions for the study of clinical genetics - Written and edited by recognized leaders in the field - Presents new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics

Growing consumer interest in organic and herbal-based products has led to great demand in the botanicals industry in the past few years. However, the growing number of products utilizing medicinal and aromatic plants (MAPs) has threatened an estimated 9,000 medicinal plant species worldwide, making it critical to reevaluate their research and development, production, and utilization. Continuing advances in Omics methodologies and instrumentation are essential to understanding how plants cope with the dynamic nature of their growing environment, how yields and characteristics can be improved, and how to most effectively direct conservation efforts. With a focus on metabolomics, genomics, proteomics, transcriptomics, and more, Medicinal and Aromatic Plants: Expanding Their Horizons through Omics illustrates the genetic mechanisms of MAPs, providing a better understanding of MAPs conservation and methods to improve characteristics for medical applications. With an introduction on the role of MAPs in human health, subsequent chapters discuss using proteomics to increase MAP yields and plant quality, genome editing, and CRISPR/Cas9. A valuable resource for farmers, scientists, chemists, biochemists, pharmacists, and students interested in medicinal and aromatic plants and plant biology, Medicinal and Aromatic Plants: Expanding Their Horizons through Omics ensures readers have the background knowledge to put the necessary methodologies into practice themselves. - Includes in-depth analysis of Omics technologies for the enhancement of MAPs - Discusses applications of MAPs including their role in human healthWritten by world-wide leading experts in the field

Mucosal Vaccines: Innovation for Preventing Infectious Diseases discusses basic knowledge and discovery in the area of mucosal immunology and its related scientific fields. This completely updated, revised and authoritative treatise covers all aspects of mucosal vaccines, including their development, mechanisms of action, molecular/cellular aspects and practical applications. The book is organized in a unique format with basic, clinical and practical aspects described and discussed. The accumulated knowledge and new discoveries on the development of mucosal vaccines are logically introduced and discussed in an easy-to-understand format. - Provides the latest views on mucosal vaccines - Applies basic and current principles in the field of mucosal immunology and related scientific fields (e.g., microbiology, infectious diseases, systems biology, medicine, dentistry, veterinary medicine and translational research) to the development of new vaccines - Links basic, clinical and practical aspects of mucosal vaccines to different infectious diseases - Presents user-friendly organization using attractive illustrations

This completely updated and expanded 2nd edition of Systemic Lupus Erythematosus, A Manual includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter is short and is presented critically with selected references, which should be valuable to a wider audience. This book combines basic with clinical science to help internists and specialists in the diagnosis and management of patients with SLE. It is a quick referral for people in the pharmaceutical industry in their efforts to bring much-needed drugs. It provides all the needed information to basic researchers old and new alike, who wish to enter the field of lupus and systemic autoimmunity in general. - Focused state-of-the-art chapters prepared by top-notch experts in the field - Latest understanding of cellular, molecular, biochemical aspects of disease pathogenesis - Advanced aspects of genetic, microbiome, environmental, hormonal, and immunological contribution to the expression of the disease - Current understanding of clinical features of the disease - Recent efforts to develop new treatments

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. - Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases - Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases - Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)

Drug Safety in Developing Countries: Achievements and Challenges provides comprehensive information on drug safety issues in developing countries. Drug safety practice in developing countries varies substantially from country to country. This can lead to a rise in adverse reactions and a lack of reporting can exasperate the situation and lead to negative medical outcomes. This book documents the history and development of drug safety systems, pharmacovigilance centers and activities in developing countries, describing their current situation and achievements of drug safety practice. Further, using extensive case studies, the book addresses the challenges of drug safety in developing countries. - Provides a single resource for educators, professionals, researchers, policymakers, organizations and other readers with comprehensive information and a guide on drug safety related issues - Describes current achievements of drug safety practice in developing countries - Addresses the challenges of drug safety in developing countries - Provides recommendations, including practical ways to implement strategies and overcome challenges surrounding drug safety

Advances in Immunology, Volume 148 offers the latest release in a long-established and highly respected publication, presenting current developments and comprehensive reviews in immunology. Sections in this new volume include chapters on histone deacetylases as targets in autoimmune and autoinflammatory diseases, the role of NK cell as central communicators in cancer immunity, and the mechanism and regulation of class switch recombination by transcriptional control element. - Presents current developments and comprehensive reviews in immunology - Provides the latest in a longstanding, respected serial on the subject matter - Focuses on recent advances in the advancing area of the mechanisms involved in the evolution of HIV-1 neutralizing antibodies

Rhinovirus Infections: Rethinking the Impact on Human Health and Disease provides a timely review of the impact of rhinovirus infections on human health. It identifies disease mechanisms relating to the virus, human host and environmental factors. This viewpoint allows us to look forward to the development of treatments for a virus for which treatment options are currently non-existent. By providing detailed insights into this virus, its host and the environmental factors that play into rhinovirus induced diseases, this book explains disease mechanisms and summarizes existing and developing therapeutic approaches for better research, diagnosis and potential treatments. - Provides insight into viral diversity and identification of virulence factors, showing how the subtype of rhinovirus affects susceptibility to diseases - Explores host and environmental factors, explaining how age, health status, genotype, lifestyle and environment influence the outcome of a rhinovirus infection - Covers vaccines and treatments, discussing the health burden associated with rhinovirus infections and the driving development of an increasing array of treatment approaches

Mechanisms and Manifestations of Obesity in Lung Disease is a complete resource on the epidemiology and molecular mechanisms related to obesity and lung disease. Obesity has not simply changed the epidemiology of pulmonary disease, it has had a profound impact on the pathophysiology of common pulmonary diseases. As the obesity epidemic has taken hold throughout the developed world, scientists and clinicians are now challenged with identifying the mechanisms by which obesity alters lung health and the pathogenesis of lung diseases. This book is an important new resource for both clinicians and scientists dealing with these new health problems in pulmonary medicine. - Presents an all-in-one resource that describes the impact of obesity on the development and severity of lung disease - Details the molecular and immunologic mechanisms by which obesity impacts the pathogenesis and outcomes of lung disease - Includes contributions from authors who are internationally recognized as leaders in the area of obesity and lung disease

Genomic and Precision Medicine: Infectious and Inflammatory Disease, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. - Offers comprehensive coverage of infectious and inflammatory disease genomics - Provides succinct commentary and key learning points to assist providers with the implementation of genomic and personalized medicine - Presents an up-to-date overview on major opportunities for genomic and personalized medicine - Includes case studies that highlight the practical use of genomics in the management of patients

Advances in Immunology, Volume 142, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release focusing on the advancing area of the mechanisms involved in the evolution of HIV-1 neutralizing antibodies. - Presents current developments and comprehensive reviews in immunology - Provides the latest in a longstanding, respected serial on the subject matter - Focuses on recent advances in the advancing area of the mechanisms involved in the evolution of HIV-1 neutralizing antibodies

Theory of Endobiogeny, Volume 3: Advanced Concepts for Treatment of Complex Clinical Conditions explains complex and multi-factorial disorders and diseases using the theory of endobiogeny. It provides detailed applications of biological modeling, in-depth assessment into common disorders, an endobiogenic analysis, guidance on using biological modeling tools, and suggestions for treatment using standard of care treatments that also take into account diet, lifestyle and medicinal plants. This approach is an evolution in thinking from reductionism to holism, offering advice for symptomatic treatments that can be used in conjunction with a new way of thinking about diseases and disease management. - Covers complex and multi-factorial disorders and diseases using the theory of endobiogeny - Provides detailed applications of biological modeling that can be used within current clinical practice - Extends systems biology from the cell level to the physiology level using pattern recognition

Marine enzymes and specialized metabolism - Part B, Volume 605 in the Methods in Enzymology series, highlights experimental methods on diverse marine enzymes involved in the construction of bioactive natural product molecules. Unique sections in this new release include discussions on polysaccharide-degrading enzymes from marine gastropods, radical SAM epimerases from sponge microbes, DMS/P demethylase in bacteria, reconstitution of particulate methane monooxygenase into membrane mimetics, the structure and function of cyanobactin enzymes, marine cyanobacterial polyketide beta-branching enzymology, marine cyanobacterial PKS-NRPS enzymology and structural biology, biochemical profiling of DMSP lyases, and more. - Subject not before covered in a methods book - Authority and expertise of the contributors

The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment. - Provides the accurate and cutting-edge information on autoimmunity epigenetics - Wide coverage appeals to those interested in fundamental epigenetics and inheritance to those with more clinical interests - Critical reviews of the mean of deriving and analysing autoimmunity epigenetics information as well as its translational potential - Up-to-date coverage of emerging topics in autoimmunity epigenetics

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. - Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease - Explains the practice of'molecular medicine and the translational aspects of molecular pathology - Teaches from the perspective of'integrative systems biology - Enhanced digital version included with purchase

Advances in Immunology, Volume 138, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release including chapters on Eosinophil Development, Disease Involvement, and Therapeutic Suppression, Immunoglobulin A responses to the microbiota, Unexpected roles for intracellular complement in the regulation of TH1 responses, Magnesium in T cell signaling, and immunological synapse and T cell signaling. - Contains contributions from leading authorities in immunology - Informs and updates on the latest developments in the field of immunology

G Protein-Coupled Receptors in Immune Response and Regulation, Volume 136 presents emerging concepts related to the role of GPCRs in immune response and regulation. Users will find updated chapters on a variety of topics, including Beta-adrenergic signaling in the onset and progression of asthma, the Emerging roles of Regulators of G protein signaling (RGS) proteins in the immune system, information on Kinin receptors in immune response and pathogenic infections, and sections on GPCR signaling in C. elegans and its implications in immune response, GPCR Kinases in Inflammatory response and signaling, and GRK2 in Inflammation: Regulation of T cell receptors and IgE signaling. Chapters in this book discuss not only the well-known aspects of GPCR signaling in immunology, but also presents many emerging paradigms that have not yet been reported in classical textbooks. Each chapter presents a forward-looking discussion, providing a glimpse of the tremendous potential associated with the specific receptor systems discussed. - Brings together contributions from leading experts in the area of GPCR biology - Discusses current paradigms and the future potential of understanding GPCR signaling in immune response and regulation - Presents the first of its kind book to focus on specific GPCR systems in various aspects of immunology, all brought together in one volume

New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury. - Comprehensive overview of basic approaches and translational development of new therapies for TBI - Edited by a prominent TBI researcher that includes contributions by leading global researchers in the field - Presents a great resource for researchers and practitioners to learn more about the many evolving preclinical studies and clinical trials currently underway, and the challenges of bringing translational studies in TBI to the clinic

Chromatin Proteins and Transcription Factors as Therapeutic Targets, the latest volume in the Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. - Provides cutting-edge developments in the field - Contains chapters written by authorities - Targeted to a wide audience of researchers, specialists, and students

Advances in Immunology, Volume 135, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this latest update including chapters on GPCR Biology, the Role of Caveolin-1 in BCR and TCR Receptors, New Developments in the Chemokine Field, and The Complement System in Developmental Neurobiology and Neurodegeneration. Readers will find comprehensive information on molecular and cellular activation mechanisms, phylogeny and molecular evolution and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. - Contains contributions from leading authorities in immunology Informs and updates on all the latest developments in the field of immunology

Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. - Contains tables, pictures, and multimedia features that enhance the learning process - In-depth coverage allows readers from a range of backgrounds to benefit from the material - Provides handy cross-referencing between articles to improve readability, including easy access from portable devices

Nutraceuticals: Efficacy, Safety and Toxicity brings together all current knowledge regarding nutraceuticals and their potential toxic effects as written by the scientists at the forefront of their study. Users will find an introduction to nutraceuticals, herbal medicines, ayurvedic medicines, prebiotics, probiotics, and adaptogens, along with their use and specific applications. This essential reference then discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and their interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered, providing a comprehensive overview of the most effective tools for the evaluation, safety, and toxicity of nutraceuticals, prebiotics, probiotics, and alternative medicines. - Grants an overview of the current state-of-the-science of nutraceuticals, their use and applications, and known adverse effects - Provides effective tools to evaluate the potential toxicity of any nutraceutical - Includes details of regulatory issues as written by international experts

Systemic Lupus Erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. - Provides the very latest overview of the pathogenesis of SLE - Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease - Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more - Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage - Discusses the latest treatment options on disease modifying or disease controlling agents - Provides'one stop'coverage of all the latest scientific and clinical developments in SLE

Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March provides valuable insights on the atopic diseases, including asthma, allergic rhinitis, atopic dermatitis, and food allergies, which have developed into major health problems in most parts of the world. As the natural history of these chronic diseases has been extensively studied, including their major genetic, environmental, and lifestyle determinants and potential protective factors, the book presents tactics on how pediatric allergists can provide early intervention. In addition, the book unites key, global experts in the field who summarize their collective, and current, knowledge of the early stage of the'Atopic March', along with novel ideas for potential options of prevention. - Summarizes the current knowledge of the epidemiological, genetic, and cellular basis of allergic diseases - Ideal reference for the study of allergies in young children, atopic dermatitis, allergic rhinitis, childhood asthma, and food allergies - Provides landmark findings in the field of immunology and allergy development - Fulfills the need for a book that focuses on primary and secondary allergy prevention, especially during the first years of life - Unites key, global experts in the field who summarize their collective, and current, knowledge, along with novel ideas for potential options of prevention

Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency. - The most comprehensive text on mucosal immunology from internationally recognized experts in the field - Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases - Contains nine new chapters and an expanded appendix

Comparative Biology of the Normal Lung, Second Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung. - Edited and authored by experts in the field to provide an excellent and timely review of cross-species comparisons that will help you interpret and compare data from animal studies to human findings - Incorporates lung anatomy and physiology, cell specific interactions and immunological responses to provide you with a single and unique multidisciplinary source on the comparative biology of the normal lung - Includes new and expanded content on neonatal and aged lungs, developmental processes, cell signaling, antioxidants, airway cells, safety pharmacology and much more - Section IV on Physical and Immunological Defenses has been significantly updated with 9 new chapters and an increased focus on the pulmonary immunological system

Nutritional supplement research concerning brain health and neurological disease is becoming an important focus. While nutritional supplements are very popular for general health and well being, the effectiveness of common supplements and their impact on general brain health and for the treatment or prevention of neurological disease is not clearly understood. This comprehensive introduction to bioactive nutraceuticals for brain and neurological provides a foundation review for research neuroscientists, clinical neurologists, pharmacology researchers and nutrition scientists on what we know now about these supplements and the brain and where focused research is still necessary. - Foundational review content covering nutrition and brain and neurological health - Reviews known nutritional supplements and impact on brain and neurological health - Comprehensive coverage ideal for research scientists and clinical practitioners

Developing Costimulatory Molecules for Immunotherapy of Diseases highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy using either humanized antibodies against CD80, CD86, and other costimulatory molecules or CD28 fusinogenic proteins in the treatment of diseases, including allergies, asthma, rheumatoid arthritis, multiple sclerosis, lupus nephritis, severe psoriasis, vulgaris tuberculosis, thopoid, transplantation therapeutic, cancer, and inflammation. The text aims to provide the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families, with the hope that targeting these families will yield new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases. - Highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy - Provides the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families - Targets new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. - Contributions from leading authorities - Informs and updates on all the latest developments in the field

Animal Biotechnology introduces applications of animal biotechnology and implications for human health and welfare. It begins with an introduction to animal cell cultures and genome sequencing analysis and provides readers with a review of available cell and molecular tools. Topics here include the use of transgenic animal models, tissue engineering, nanobiotechnology, and proteomics. The book then delivers in-depth examples of applications in human health and prospects for the future, including cytogenetics and molecular genetics, xenografts, and treatment of HIV and cancers. All this is complemented by a discussion of the ethical and safety considerations in the field.Animal biotechnology is a broad field encompassing the polarities of fundamental and applied research, including molecular modeling, gene manipulation, development of diagnostics and vaccines, and manipulation of tissue. Given the tools that are currently available and the translational potential for these studies, animal biotechnology has become one of the most essential subjects for those studying life sciences. - Highlights the latest biomedical applications of genetically modified and cloned animals with a focus on cancer and infectious diseases - Provides firsthand accounts of the use of biotechnology tools, including molecular markers, stem cells, and tissue engineering

Measures of Personality and Social Psychological Constructs assists researchers and practitioners by identifying and reviewing the best scales/measures for a variety of constructs. Each chapter discusses test validity, reliability, and utility. Authors have focused on the most often used and cited scales/measures, with a particular emphasis on those published in recent years. Each scale is identified and described, the sample on which it was developed is summarized, and reliability and validity data are presented, followed by presentation of the scale, in full or in part, where such permission has been obtained. Measures fall into five broad groups. The emotional disposition section reviews measures of general affective tendencies, and/or cognitive dispositions closely linked to emotion. These measures include hope and optimism, anger and hostility, life satisfaction, self-esteem, confidence, and affect dimensions. Emotion regulation scales go beyond general dispositions to measure factors that may contribute to understanding and managing emotions. These measures include alexithymia, empathy, resiliency, coping, sensation seeking, and ability and trait emotional intelligence. The interpersonal styles section introduces some traditional social–psychological themes in the context of personality assessment. These measures include adult attachment, concerns with public image and social evaluation, and forgiveness. The vices and virtues section reflects adherence to moral standards as an individual characteristic shaped by sociocultural influences and personality. These measures include values and moral personality, religiosity, dark personalities (Machiavellianism,narcissism, and subclinical psychopathy), and perfectionism. The sociocultural interaction and conflict section addresses relationships between different groups and associated attitudes. These measures include cross-cultural values, personality and beliefs, intergroup contact, stereotyping and prejudice, attitudes towards sexual orientation, and personality across cultures. - Encompasses 25 different areas of psychology research - Each scale has validity, reliability info, info on test bias, etc - Multiple scales discussed for each construct - Discussion of which scales are appropriate in which circumstances and to what populations - Examples of scales included

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies. - Reviews on hot topics of interest in small molecule drug discovery heavily pursued by industrial research organizations - Provides preclinical information in the context of chemical structures - Knowledgeable section editors who evaluate invited reviews for scientific rigor

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. - Provides information on cancer research - Oustanding and original reviews - Suitable for researchers and students

Women and Health is a comprehensive reference that addresses health issues affecting women of all ages — from adolescence through maturity. It goes far beyond other books on this topic, which concentrate only on reproductive health, and has a truly international perspective. It covers key issues ranging from osteoporosis to breast cancer and other cancers, domestic violence, sexually transmitted diseases, occupational hazards, eating disorders, heart disease and other chronic illnesses, substance abuse, and societal and behavioral influences on health. In this second edition of Women and Health, chapters thoughtfully explore the current state of women's health and health care, including the influences of sex and gender on the occurrence of a wide variety of diseases and conditions. All chapters have been extensively updated and emphasize the epidemiology of the condition — the etiology, occurrence, primary and secondary prevention (screening), risk factors, surveillance, changing trends over time, and critical analysis of the diagnostic and treatment options and controversies. Treatment sections in each chapter have been expanded to create a stronger dialogue between epidemiologists and women's health practitioners. - Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of women's health issues, as opposed to searching through thousands of journal articles - Provides a common language for epidemiologists, public health practitioners, and women's health specialists to discuss the behavioral, cultural, and biological determinants of women's health - Researchers and medical specialists will learn how the gender-specific risks and features of one organ system's diseases affect the health of other organ systems - For example: Hormone replacement therapy used to treat imbalance within the endocrine system is also being used to prevent and treat cardiovascular disease; Drugs developed for type 2 diabetes are now being used in chemoprevention - Orients the non-gerontologist about the importance of considering the entire life cycle of women within research designs and treatment plans - Professors teaching courses in women's health will use slides and additional materials to structure lectures/courses; students will use slides as a unique resource to study for exams

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. - Contributions from leading authorities - Informs and updates on all the latest developments in the field

Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development. With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development. - Provides case studies in applications of pharmacodynamic and predictive markers in drug development in oncology, autoimmunity, respiratory diseases and infectious diseases - Shows how to identify potential new therapeutic targets in different diseases and provides examples of potential new disease indications for life cycle management of drugs - Authored by leading international experts from industry and academia

This new volume of Advances in Pharmacology explores the current state of Alzheimer's disease research and therapeutics. Chapters cover such topics as the B cell targeted therapies, Lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. - Explores the current state of Alzheimer's disease research and therapeutics - Chapters cover a variety of topics such as the B cell targeted therapies, lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin - With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike

For decades, Emery and Rimoin's Principles and Practice of Medical Genetics has provided the ultimate source for practicing clinicians to learn how the study of genetics can be integrated into practice. With almost 5,000 pages of detailed coverage, this fully online sixth edition of the classic reference adds the latest information on prenatal diagnosis, genetic screening, genetic counseling, and treatment strategies to complete its coverage of the growing field for medical students, residents and physicians involved in the care of patients with genetic conditions. Clinically oriented information is supported by expanded sections on basic principles of genetics, research approaches, and analytics to embrace the evolving population of students, researchers, and practitioners who are integrating their work to provide advanced diagnosis, prevention and treatment of human disease. With advances in high-throughput technologies propelling the closer integration of lab and clinical work, this edition bridges the gap between high-level molecular genetics and clinical application. - Features 174 review-length contributions that encompass traditional and new areas of the field - including in cancer genetics, genomic technologies, and molecular assays - Provides many thousands of pertinent literature references guiding the reader in identifying related topics - Fully illustrated with hundreds of color images, supporting identification, concept illustration and method processing