1. Regulatory mechanisms of stem cell differentiation: Biotechnological applications for neurogenesis.
- Author
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Marques BL, Maciel GF, Brito MR Júnior, Dias LD, Scalzo S, Santos AK, Kihara AH, da Costa Santiago H, Parreira RC, Birbrair A, and Resende RR
- Subjects
- Cell Differentiation, Neurogenesis physiology, Neurons, Neural Stem Cells, MicroRNAs genetics
- Abstract
The world population's life expectancy is growing, and neurodegenerative disorders common in old age require more efficient therapies. In this context, neural stem cells (NSCs) are imperative for the development and maintenance of the functioning of the nervous system and have broad therapeutic applicability for neurodegenerative diseases. Therefore, knowing all the mechanisms that govern the self-renewal, differentiation, and cell signaling of NSC is necessary. This review will address some of these aspects, including the role of growth and transcription factors, epigenetic modulators, microRNAs, and extracellular matrix components. Furthermore, differentiation and transdifferentiation processes will be addressed as therapeutic strategies showing their significance for stem cell-based therapy., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022. Published by Elsevier Ltd.)
- Published
- 2023
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