1. Impaired N-cadherin-mediated adhesion increases the risk of inducible ventricular arrhythmias in isolated rat hearts
- Author
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Xiao-Mei Ding, Hongjun Zhu, Ke-jiang Cao, Jian-gang Zou, and Xiao-feng Hou
- Subjects
medicine.medical_specialty ,Cadherin ,Chemistry ,General Engineering ,Effective refractory period ,General Physics and Astronomy ,Connexin ,General Medicine ,Anatomy ,General Biochemistry, Genetics and Molecular Biology ,Nerve conduction velocity ,Adherens junction ,Endocrinology ,Internal medicine ,medicine ,Action potential duration ,Repolarization ,General Agricultural and Biological Sciences ,Perfusion - Abstract
Recent studies suggest that cadherin-mediated adherens junctions may be impaired in diseases and pathologic processes related to ventricular arrhythmias, which are concomitant with decreased connexin 43 (Cx43). In this study, we evaluated the acute arrhythmogenic effects of adherens junction impairment in isolated rat hearts. A total of 56 hearts isolated from adult male rats were perfused with 0.2 mM AHAVD, a synthetic peptide that specifically inhibits N-cadherin (n = 18); 0.2 mM IPPINL, a nonsense peptidase that contains the highly conserved cadherin sequence (n = 18), and oxygenated Krebs–Henseleit buffer as the control (n = 20). Under programmed stimuli, ventricular tachyarrhythmias were induced more in the AHAVD-perfused hearts (9/18) than the IPPINL-perfused hearts (4/18) and those in the control (3/20) group (P
- Published
- 2012