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Objective: to assess the specific features of the hemorheological profile and lipid spectrum in patients in the acute phase of ischemic stroke inthe presence of arterial hypertension (AH). Subjects and methods. Fifty patients divided into 2 groups were examined. Group 1 included 30 patients (mean age 67 .0± 10.1 years) with acute ischemic stroke. They all were diagnosed as having grade 2 AH as evidenced by medical records. Group 2 comprised 20 apparentlyhealthy individuals (50 ± 48 years) without AH. The parameters of the hemorheological profile and lipid spectrum were determined in allthe enrolled patients.Results. Among the blood macrorheological characteristics, there was a rise in plasma viscosity in the study group, which was 17 % greaterthan in group 2 (2.10 ± 0.25 and 1.80 ± 0.23 mPas, respectively; p < 0.01). The most important results were obtained in the study of bloodmicrorheological characteristics. All the study parameters were considerably higher in the patients with acute ischemic stroke than those in the apparently healthy individuals. Thus, the formation rate for aggregates (0.50 ± 0.24 and 0.32 ± 0.20 relative units in Groups 1 and 2, respectively; p < 0.01) and their sizes (7.30 ± 1.02 and 6.20 ± 0.63 relative units, respectively; p < 0.01) were more in the study group thanthose in the control one. At the same time, in the study group the integral aggregation index was 80 % higher (p < 0.01) than that in the control. However, in the patients with acute ischemic stroke, the erythrocyte rigidity index was lower than that in apparently healthy patients (0.71 ± 0.07 and 0.76 ± 0.09 relative units, respectively; p < 0.05). In Group 1 patients, impairments of the hemorheological profile were accompanied by changes in the lipid spectrum. Despite the fact that no differences in total cholesterol levels were recorded in the study groups (4.7 ± 1.5 and 5.20 ± 1.02 mmole/l in Groups 1 and 2, respectively), there was a substantial change in the other parameters of the lipid spectrum. Thus, in the patients with acute ischemic stroke, the levels of high-density lipoprotein cholesterol were 62 % lower than in the control group (p < 0.01) and the atherogenicity coefficient was 1.5-fold higher in the study group than in the control one (p < 0.01). At the same time, there were increases in triglycerides in Groups 1 and 2 (1.33 ± 0.74 and 0.96 ± 0.55 mmol/l, respectively; p < 0.05) and low-density lipoprotein cholesterol in these groups (3.10 ± 0.78 and 1.96 ± 0.60 mmol/l, respectively; p < 0.01).Conclusion. The changes in the lipid spectrum and hemorheological profile can provide a more detailed insight into the pathogenic processesoccurring in the patients in the acute phase of ischemic stroke.

Objective — to study therapeutic equivalence (efficacy, safety and tolerability) and hemorheological activity of original clopidogrel and itsgeneric in patients of high cardiovascular risk.Materials and methods. 50 patients with stable angina pectoris were randomized into 2 groups of consecutive 2-week treatment by original(plavix) and generic (plagril) clopidogrel and vice versa. ADP-induced platelet aggregation was measured at baseline and after treatment byeach of the drugs. Physical examination and adverse events were evaluated at visits.Results. After the first treatment period a significant decrease of platelet aggregation was determined in both groups. After switching to anotherdrug the decrease continued but not significantly in both groups. There were registered no adverse events associated with antiplatelet therapy.Conclusion. Equal antiplatelet activity established for plavix and plagril demonstrates their therapeutic equivalence.

Aim – to evaluate macro-and microrheology hemorheological characteristics parameters in patients with COPD, and their dependence on the severity of COPD.Materials and methods. The study included 107 people, 80 patients with chronic obstructive pulmonary disease I, II, III, IV degree and 27 persons as a control group. Rheological examination included determination of the viscosity of whole blood and erythrocyte suspensions with a hematocrit (HT) 40 % in plasma and nonggregating environment, the plasma viscosity. Measuring the effectiveness of oxygen delivery to tissues produced by the formula: TO2 = Ht/η, where η — viscosity of blood. The degree of erythrocyte aggregation was evaluated by microscopy with video recording of diluted blood, and computer image analysis. Indices of rigidity of the red blood cells were calculated, indicators of internal viscosity of red blood cell content and efficiency of transport of oxygen to the tissues.Results. In patients with COPD were identified expressed disturbances of macro-and microrheology of blood parameters were identified. Blood viscosity at all shear stresses were increased by 23–27% compared with the control group, plasma viscosity – 21.5 % (p < 0.001). Indicators of hemoglobin and hematocrit (by 9.7 % and 8.8 % respectively, p < 0,001) were Significantly higher in patients with COPD. The viscosity of erythrocyte suspension to a standard hematocrit of 40 % in saline and in autologous plasma at different shear stresses were increased by 19,5–25,3 % (p < 0,001) and 22–24 % (p < 0,001), respectively. Revealed significant changes in properties of the blood stream, which in turn led to a marked reduction in oxygen-function of the blood in 27.5 % (p < 0.001).Conclusions. In patients with COPD, there are marked disturbances of macro-and microrheology of blood parameters, the viscosity of whole blood and plasma increases greatly, red blood cell deformability is reduced, and changing of the properties of the blood stream leads to decrease in its oxygenfunction. However, with increasing severity of COPD, there is no corresponding worsening of blood rheology.