1. Shape Effects of Cylindrical versus Spherical Unimolecular Polymer Nanomaterials on in Vitro and in Vivo Behaviors
- Author
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Cheng Li, Zhengkui Zhang, Wei Wu, Changren Liu, and Xiqun Jiang
- Subjects
chemistry.chemical_classification ,Multidisciplinary ,Materials science ,Science ,Nanoparticle ,02 engineering and technology ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Tissue penetration ,0104 chemical sciences ,Nanomaterials ,Chemical engineering ,chemistry ,In vivo ,Biological property ,0210 nano-technology ,Nanoscopic scale ,Research Article - Abstract
To date, how the shape of nanomaterials influences their biological properties is poorly understood, due to the insufficient controllability of current preparative methods, especially in the shape and size of nanomaterials. In this paper, we achieved the precise syntheses of nanoscale unimolecular cylindrical polymer brushes (CPBs) and spherical polymer nanoparticles (SPNPs) with the same volume and surface chemistry, which ensured that shape was essentially the only variable when their biological performance was compared. Accurate shape effects were obtained. Impressively, the CPBs had remarkable advantage in tissue penetration over the SPNPs. The CPBs also exhibited higher cellular uptake and rapider body clearance than the SPNPs, whereas the SPNPs had longer blood circulation time, rapider tumor vascular extravasation, and higher tumor accumulation than the CPBs. Additionally, this work also provided a controllable synthesis strategy for nanoscale unimolecular SPNPs by integrating 21 CPBs to a β -cyclodextrin core, whose diameter in dry state could be up to 45 nm.
- Published
- 2019