1. 長崎県油症患者における制御性T細胞(Treg細胞)の検討
- Author
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Yoshiko, Mine, Yutaka, Kuwatsuka, and Atsushi, Utani
- Subjects
Treg ,Porphyrias ,制御性T細胞 ,油症 ,Humans ,chemical and pharmacologic phenomena ,Prospective Studies ,Neutral fat ,T-Lymphocytes, Regulatory ,Yusho ,Aged ,中性脂肪 - Abstract
Dioxin and dioxin-like compounds receptor (Ahr) mainly expressed on the surface of regulatory T (Treg) cell and Th17 cell could regulate immunological functions in the Yusho patients. We prospectively analyzed data obtained in a total of 56 cases of Yusho, which include patients identified ('Nintei' ) or non-identified ( 'Minintei') or identified as a family member, at the annual health check in 2014. The number of Treg cell showed lower among identified patients compared with non-identified group or family identified group (p = 0.4184 and p = 0.291, respectively). There was also a strong correlation between serum levels of neutral fat and the number of Treg cells (p = 0.0313). These results suggest that Treg cell plays a principal role in the immune response among Yusho patients. more...
- Published
- 2015