1. The Association of Cytokines with Severe Dengue in Children
- Author
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Tran Van Dat, Vu Thi Que Huong, Julia N.A. Mangione, Nguyen Thi Phuong Lan, Tran Thi Ngoc Ha, Evaristus Chibunna Mbanefo, Cao Thi Phi Nga, Tran Thi Thuy, Lam Quoc Bao, Vo Van Tuong, Nguyen Tien Huy, Ha Manh Tuan, and Kenji Hirayama
- Subjects
Original Paper ,business.industry ,medicine.medical_treatment ,Public Health, Environmental and Occupational Health ,Case-control study ,shock ,Dengue virus ,medicine.disease ,medicine.disease_cause ,Virology ,Severity ,Dengue fever ,Pathogenesis ,Association ,Dengue ,Infectious Diseases ,Cytokine ,Immune system ,Interferon ,Immunology ,medicine ,Cytokine storm ,business ,medicine.drug - Abstract
Background: Dengue virus infection is a major public health problem. A hypothesis put forward for severe dengue is the cytokine storm, a sudden increase in cytokines that induces vascular permeability. Previous studies and our recent meta-analysis showed that IL-6, IL-8, IFNγ, TNFα, VEGF-A and VCAM-1 are associated with dengue shock syndrome. Therefore, in this study we aim to validate the association of these cytokines with severe dengue. Methods & Findings: In a hospital based-case control study in Vietnam, children with dengue fever, other febrile illness and healthy controls were recruited. Dengue virus infection was confirmed by several diagnostic tests. Multiplex immunoassay using Luminex technology was used to measure cytokines simultaneously. A positive association with dengue shock syndrome was found for VCAM-1, whereas a negative association was found for IFNγ. Furthermore, multivariate logistic analysis also showed that VCAM-1 and IFNγ were independently correlated with dengue shock syndrome. Conclusion: IFNγ and VCAM-1 were associated with dengue shock syndrome, although their role in the severe dengue pathogenesis remains unclear. Additional studies are required to shed further light on the function of these cytokines in severe dengue., Tropical Medicine and Health, 42(4), pp.137-144; 2014
- Published
- 2014