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We have previously proposed a technique for estimating the static gain values and impulse response of the arterial and cardiopulmonary total peripheral resistance (TPR) baroreflex by mathematical analysis of beat-to-beat fluctuations in arterial blood pressure, cardiac output, and stroke volume. In this study, we evaluated the technique with respect to spontaneous hemodynamic variability measured from seven conscious dogs before and after chronic arterial baroreceptor denervation. Our results show that the technique correctly predicted the alterations in TPR baroreflex functioning that are known to occur following the baroreceptor denervation.