Objective To explore the coordination relationship and spatial pattern of health resource allocation and socio- economic development in Sichuan Province, to provide references for promoting the high-quality development of health and social economy. Methods Entropy method, comprehensive evaluation index, and coupling coordination degree model were used to evaluate the level and coupling coordination degree of health resources and socio-economic development. Hot spot analysis was used to explore the characteristics of spatial agglomeration. Results From 2017 to 2021, the development level of health resource allocation in different economic regions of Sichuan Province was in the following order: northwest Sichuan Ecological Demonstration Zone (0.59), Panxi Economic Zone (0.35), Chengdu Plain Economic Zone/Southern Sichuan Economic Zone (0.30), and Northeast Sichuan Economic Zone (0.23). The order of social and economic development level was as the follows: Chengdu Plain Economic Zone (0.25), Panxi Economic Zone (0.16), South Sichuan Economic Zone (0.15), Northeast Sichuan Economic Zone (0.10), and Northwest Sichuan Ecological demonstration Zone (0.08). In the past five years, most of the coupling coordination degree of different economic regions showed an increasing trend. Only the average coupling coordination degree of northeast Sichuan economic zone was less than 0.4, which was in a maladjusted recession, while the average coupling coordination degree of the remaining four economic zones was between 0.4 and 0.5, which was in transition. harmony and generally subject to the lag of social and economic development. The level of coupling coordination showed a spatial pattern of "high in the west and low in the east", and the agglomeration characteristics were mainly "high-high" agglomeration area in western Sichuan and "low-low" agglomeration area in northeastern Sichuan. Conclusion There are obvious regional differences in the allocation of health resources and the level of socio-economic development in Sichuan Province. The trend of coupling and coordination between the two systems is gradually improving, but the degree of coordination is not high. In addition, the coupling coordination level has significant spatial characteristics, and the local area shows agglomeration effect. [ABSTRACT FROM AUTHOR]