1. Association between Dietary Total Antioxidant Capacity and Odds of Preeclampsia: A Case-control Study
- Author
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Mahshid Taherkhani, Farzaneh Montazerifar, Azita Hekmatdoost, Bahram Rashidkhani, Abolfazl Payandeh, and Mansour Karajibani
- Subjects
hypertension ,antioxidants ,oxidative stress ,preeclampsia ,oxygen radical absorbance capacity ,diet. ,Agriculture ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Background: Preeclampsia may cause maternal and child morbidity and mortality. Evidence suggests that oxidative stress may be involved in the development of preeclampsia; however, the role of dietary total antioxidant capacity (DTAC) on preeclampsia risk has not yet been elucidated. Thus, this study aims to assess the relationship between DTAC and odds of preeclampsia. Methods: This case-control study was conducted on 240 pregnant women (preeclampsia, n=60; controls, n=180) in Qazvin, Iran. Controls were 3:1 ratio matched with cases in terms of participants’ age and gestational age. Dietary intakes were assessed using a validated food frequency questionnaire evaluating the preceding year. DTAC was measured by two methods: ferric reducing antioxidant potential (FRAP) and oxygen radical absorbance capacity (ORAC). Multivariable logistic regression was employed to evaluate the association between preeclampsia and DTAC and also selected antioxidants. Results: After controlling for potential confounders, a significant inverse relationship was found between ORAC and preeclampsia; individuals in the highest tertile of ORAC were 67% less likely to have preeclampsia than those in the lowest tertile of ORAC (OR: 0.33; 95% CI: 0.11-0.97; P-trend
- Published
- 2025