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1. Classifying Proposals of Decentralized Autonomous Organizations Using Large Language Models

Author

Ziegler, Christian, Miranda, Marcos, Cao, Guangye, Arentoft, Gustav, and Nam, Doo Wan

Subjects
Computer Science - Computers and Society, H.0
Abstract

Our study demonstrates the effective use of Large Language Models (LLMs) for automating the classification of complex datasets. We specifically target proposals of Decentralized Autonomous Organizations (DAOs), as the clas-sification of this data requires the understanding of context and, therefore, depends on human expertise, leading to high costs associated with the task. The study applies an iterative approach to specify categories and further re-fine them and the prompt in each iteration, which led to an accuracy rate of 95% in classifying a set of 100 proposals. With this, we demonstrate the po-tential of LLMs to automate data labeling tasks that depend on textual con-text effectively.

Published
2024

4. Kapitel 2 Die Finanzgerichtsordnung

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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5. Teil O Vollstreckung wegen Geldforderungen

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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6. Titelei/Inhaltsverzeichnis

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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7. Teil C Die gerichtliche Entscheidung

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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8. Teil B Die Klage

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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9. Vorwort zur 22. Auflage

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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10. Teil H Die Lehre vom Steuerverwaltungsakt

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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11. Teil J Festsetzungsverjährung

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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12. Teil A Grundlagen

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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15. Teil A Die Finanzgerichtsbarkeit

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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16. Teil C Steuerbegünstigte Zwecke

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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17. Teil M Außenprüfung

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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18. Teil F Die Haftung

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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20. Autoren

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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22. Teil E Kosten (§§ 135 ff. FGO)

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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23. Teil K Erhebungsverfahren

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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24. Kapitel 1 Die Abgabenordnung

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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25. Teil D Datenschutz und Steuergeheimnis

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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27. Teil E Steuerschuldrecht

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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28. Teil L Korrektur von Steuerverwaltungsakten

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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33. Ultra-Low-Power High PSRR Sub-1 V Voltage Reference Circuit in 22 nm FDSOI CMOS

Author

Dossanov, Adilet, Ziegler, Christian, and Issakov, Vadim

Abstract

This brief presents an ultra-low-power sub-1V voltage reference circuit using a self-cascode technique to improve power supply rejection ratio (PSRR) for battery-powered applications. The proposed voltage reference circuit has been fabricated in 22 nm fully-depleted silicon-on-insulator (FDSOI) CMOS technology, and it occupies an active area of 0.0104 $\text {mm}^{{2}}$ . The measured average output voltage $\text {V}_{\text {REF}}$ from 12 samples at room temperature is 598 mV with a standard deviation of 0.37%. The $\text {V}_{\text {REF}}$ shows measured average temperature coefficient $\text {TC}_{\text {avg}}$ of 61 $\text {ppm/}^{\circ }\text {C}$ over the temperature range of −40°C to 120°C, line sensitivity of 0.12%/V from 1.2V to 1.8V supply voltages, and measured PSRR of 66 dB at 10 Hz. A total power consumption is 45.6nW from a 1.2V supply voltage.

Published
2024
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34. Automatisierungspotentialmatrix

Author

Ziegler, Christian and Rößler, Markus Philipp

Abstract

In the age of the digital revolution and high global competitive pressure, it is essential for companies to identify and strategically exploit automation potentials. The Automation Potential Matrix evaluates the suitability for automation and the expected business benefits. Through this holistic analysis approach, groundbreaking strategic decisions for production can be made in a very short time, while simultaneously avoiding the most significant mistakes in the selection of the form of automation.

Published
2024
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35. Datengetrieben ins Zeitalter der Innovation : die evidenzbasierte Revolution

Author

Ziegler, Christian, Feuz, Martin, Yerebakan, Lisa, Kirst, Alyssa, Del Ponte, Paolo, Bosia, Francesco, Walker, Nina, Ziegler, Christian, Feuz, Martin, Yerebakan, Lisa, Kirst, Alyssa, Del Ponte, Paolo, Bosia, Francesco, and Walker, Nina

Abstract

Innovationen haben die Kraft, ein Unternehmen als Vorreiter und Marktbereiter erfolgreich zu machen – oder zum Grab für Investitionen, Zukunftspläne und Karrieren zu werden. Entsprechend gross sind oft Druck und Unsicherheit für alle Beteiligten: - Führungsetagen tun sich schwer damit, sich auf Innovationsvorhaben festzulegen, da zu viele Köche im Entscheidungsbrei mitrühren wollen. - Innovationen, die beim ersten Kontakt mit dem Markt implodieren, schüren Versagensängste auf persönlicher und Organisationsebene. - Verwaltungsrat, Geschäftsleitung und Investoren pushen Innovationstätigkeit, in der Hoffnung, dass R&D Investitionen zu neuen Produkten mit starken Verkaufszahlen führen. Und mittendrin stehen die eigentlichen Projektverantwortlichen, die den Innovationsprozess vorantreiben und dabei die richtigen Entscheidungen treffen sollen, aber nur selten über das verfügen, was sie dazu überhaupt befähigt: eine ausreichende Evidenzgrundlage. Willkommen in einer Welt, in der es nicht überrascht, dass immer noch zu viele Innovationsprojekte scheitern. Aber auch: Willkommen in einer Welt, in der sich genau das ändern lässt. In der für erfolgskritische Entscheidungen eine Basis aus empirisch erhobenen, gut strukturierten und sauber ausgewerteten Daten geschaffen werden kann. Und in der Innovationserfolg kein Glückstreffer mehr ist, sondern die Konsequenz evidenzbasierter Entscheidungssicherheit. Genau dafür steht der Ansatz der Evidence-based Innovation (EBI). Teil 1 unserer Whitepaper Serie zu EBI zeigt, wo etablierte Innovationstechniken offene Flanken haben und erklärt, wie diese durch die effektive Anwendung des EBIAnsatzes geschlossen werden können.

Published
2024

36. Improving susceptibility of neuroendocrine tumors to radionuclide therapies: personalized approaches towards complementary treatments

Author

Richter, Susan, Steenblock, Charlotte; https://orcid.org/0000-0002-9635-4860, Fischer, Alessa; https://orcid.org/0000-0003-4555-8334, Lemm, Sandy, Ziegler, Christian G, Bechmann, Nicole; https://orcid.org/0000-0002-6932-333X, Nölting, Svenja; https://orcid.org/0000-0002-7064-590X, Pietzsch, Jens; https://orcid.org/0000-0002-1610-1493, Ullrich, Martin; https://orcid.org/0000-0001-6104-6676, Richter, Susan, Steenblock, Charlotte; https://orcid.org/0000-0002-9635-4860, Fischer, Alessa; https://orcid.org/0000-0003-4555-8334, Lemm, Sandy, Ziegler, Christian G, Bechmann, Nicole; https://orcid.org/0000-0002-6932-333X, Nölting, Svenja; https://orcid.org/0000-0002-7064-590X, Pietzsch, Jens; https://orcid.org/0000-0002-1610-1493, and Ullrich, Martin; https://orcid.org/0000-0001-6104-6676

Abstract

Radionuclide therapies are an important tool for the management of patients with neuroendocrine neoplasms (NENs). Especially [$^{131}$I]MIBG and [$^{177}$Lu]Lu-DOTA-TATE are routinely used for the treatment of a subset of NENs, including pheochromocytomas, paragangliomas and gastroenteropancreatic tumors. Some patients suffering from other forms of NENs, such as medullary thyroid carcinoma or neuroblastoma, were shown to respond to radionuclide therapy; however, no general recommendations exist. Although [$^{131}$I]MIBG and [$^{177}$Lu]Lu-DOTA-TATE can delay disease progression and improve quality of life, complete remissions are achieved rarely. Hence, better individually tailored combination regimes are required. This review summarizes currently applied radionuclide therapies in the context of NENs and informs about recent advances in the development of theranostic agents that might enable targeting subgroups of NENs that previously did not respond to [$^{131}$I]MIBG or [$^{177}$Lu]Lu-DOTA-TATE. Moreover, molecular pathways involved in NEN tumorigenesis and progression that mediate features of radioresistance and are particularly related to the stemness of cancer cells are discussed. Pharmacological inhibition of such pathways might result in radiosensitization or general complementary antitumor effects in patients with certain genetic, transcriptomic, or metabolic characteristics. Finally, we provide an overview of approved targeted agents that might be beneficial in combination with radionuclide therapies in the context of a personalized molecular profiling approach.

Published
2024

39. Abgabenordnung und Finanzgerichtsordnung

Author

Große, Thomas, primary, Melchior, Jürgen, additional, Lotz, Anja, additional, Ziegler, Christian, additional, Henk, Stefan, additional, Hudasch, Claudia, additional, and Tenberger, Christian, additional

Published
2024
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41. Muscle forces acting on the greater trochanter lead to a dorsal warping of the apophyseal growth plate.

Author

Ziegler, Christian Max, Wagner, Ferdinand, Alleborn, Karoline, Geith, Tobias, Holzapfel, Boris Michael, and Heimkes, Bernhard

Subjects
*GROWTH plate, *HUMAN growth, *MAGNETIC resonance imaging, *FEMUR
Abstract

The apophyseal growth plate of the greater trochanter, unlike most other growth plates of the human body, exhibits a curved morphology that results in a divergent pattern resembling an open crocodile mouth on plain antero‐posterior radiographs. To quantify the angular alignment of the growth plate and to draw conclusions about the function of the muscles surrounding it, we analyzed 57 MRI images of 51 children and adolescents aged 3–17 years and of six adults aged 18–52 years. We measured the angulation of the plate relative to the horizontal plane (AY angle) and the trajectories of the muscles attaching to the greater trochanter of the proximal femur. From anterior to posterior, the AY angle shows a decrease of 33.44°. In the anterior third, the cartilage is angled at a mean of 51.64°, and in the posterior third, the mean angulation is 18.6°. This indicates that the cartilage in the anterior region of the greater trochanteric apophysis is subject to more vertically oriented force vectors compared to the posterior region, as the growth plates align perpendicular to the force vectors acting on them. Combining the measured muscle trajectories with the physiological cross‐sectional areas (PCSA) available from the literature revealed that, in addition to the known internal and external lateral traction ligament systems, a third, dorsally located traction ligament system exists that may be responsible for the dorsal deformation of the AY angle. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Intrainstitutional Changes of the Treatment of Supracondylar Humerus Fracture in Children over a Period of 9 Years.

Author

Wagner, Ferdinand, Boeriu, Amalia, Eberz, Pascal, Weigert, Annabelle, Holzapfel, Boris Michael, Böcker, Wolfgang, Hubertus, Jochen, Muensterer, Oliver, Bergmann, Florian, and Ziegler, Christian Max

Subjects
ARM physiology, EVALUATION of medical care, DIAGNOSIS related groups, TEACHING methods, ACADEMIC medical centers, HUMERAL fractures, CHILDREN'S hospitals, TREATMENT duration, ACQUISITION of data, RETROSPECTIVE studies, ORGANIZATIONAL change, FRACTURE fixation, QUALITY of life, QUESTIONNAIRES, MEDICAL records, DESCRIPTIVE statistics, ELBOW fractures, PHYSICIAN practice patterns, HEALTH equity, DATA analysis software, EVALUATION, CHILDREN
Abstract

To assess changes in treatment modalities for supracondylar humerus fractures (SCHFs) at a large pediatric university hospital, we analyzed patient data from 2014 to 2022. A total of 233 SCHFs treated surgically at our hospital were included. To evaluate postoperative outcome and quality of life, DASH and EuroQol-5D-Y questionnaires were sent to patients. In addition to a significant fluctuation in fracture severity, we found an increase in training interventions (more surgeries were performed by trainees) and a significant decrease in surgery times after 2016. From 2020, there was a significant shift in the type of surgical method away from closed reduction with elastic stable intramedullary nailing (ESIN) and towards closed reduction and crossed K-wire osteosynthesis (CRK). Surgeries performed in the morning and evening hours increased, while those performed in the afternoon and after midnight decreased. After a mean follow-up of 4 years, there was no difference in elbow function between ESIN and open reduction and K-wires (ORK). Treatment with ESIN was equivalent to ORK in terms of function, at least in the medium-term follow-up. In summary, the combination of shifting treatment from SCHF to daytime hours, increasing trainee participation and using cross K-wire fixation instead of ESIN had no negative impact on surgery times. In our setting, these measures have reduced resource utilization and increased efficiency without compromising patient care. [ABSTRACT FROM AUTHOR]

Published
2024
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43. GLP-1 and PYY for the treatment of obesity: a pilot study on the use of agonists and antagonists in diet-induced rats.

Author

Oertel M, Ziegler CG, Kohlhaas M, Nickel A, Kloock S, Maack C, Sequeira V, Fassnacht M, and Dischinger U

Abstract

Objective: Combination therapies with gut hormone analogs represent promising treatment strategies for obesity. This pilot study investigates the therapeutic potential of modulators of the glucagon-like peptide 1 (GLP-1) and neuropeptide Y (NPY) system using GLP-1 receptor agonists (semaglutide) and antagonists (exendin 9-39), as well as non-selective and NPY-Y2-receptor selective peptide tyrosine tyrosine (PYY) analogs (PYY3-36/NNC0165-0020 and NNC0165-1273) and an NPY-Y2 receptor antagonist (JNJ31020028)., Methods: High-fat diet (HFD)-induced obese rats were randomized into following treatment groups: group 1, nonselective PYY analog + semaglutide (n = 4); group 2, non-selective and NPY-Y2 receptor selective PYY analog + semaglutide (n = 2); group 3, GLP-1 receptor antagonist + NPY-Y2 receptor antagonist (n = 3); group 4, semaglutide (n = 5); and group 5, control (n = 5). Animals had free access to HFD and low-fat diet. Food intake, HFD preference and body weight were measured daily., Results: A combinatory treatment with a non-selective PYY analog and semaglutide led to a maximum body weight loss of 14.0 ± 4.9% vs 9.9 ± 1.5% with semaglutide alone. Group 2 showed a maximum weight loss of 20.5 ± 2.4%. While HFD preference was decreased in group 2, a strong increase in HFD preference was detected in group 3., Conclusions: PYY analogs (especially NPY-Y2 selective receptor agonists) could represent a promising therapeutic approach for obesity in combination with GLP-1 receptor agonists. Additionally, combined GLP-1 and PYY3-36 receptor agonists might have beneficial effects on food preference.

Published
2024
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