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The self-circulating casing treatment can effectively expand the stable working range of the compressor, with little impact on its efficiency. With a single-stage transonic axial flow compressor NASA (National Aeronautics and Space Administration) Stage 35 as the research object, a multi-channel unsteady numerical calculation method was used here to design three types of self-circulating casing treatment structures: 20% Ca (axial chord length of the rotor blade tip), 60% Ca, and 178% Ca (at this time, the bleed position is at the stator channel casing) from the leading edge of the blade tip. The effects of these three bleed positions on the self-circulating stability expansion effect and compressor performance were studied separately. The calculation results indicate that the further the bleed position is from the leading edge of the blade tip, the weaker the expansion ability of the self-circulating casing treatment, and the greater the negative impact on the peak efficiency and design point efficiency of the compressor. This is because the air inlet of the self-circulating casing with an air intake position of 20% Ca is located directly above the core area of the rotor blade top blockage, which can more effectively extract low-energy fluid from the blockage area. Compared to the other two bleed positions, it has the greatest inhibitory effect on the leakage vortex in the rotor blade tip gap and has the strongest ability to improve the blockage at the rotor blade tip. Therefore, 20% Ca from the leading edge of the blade tip has the strongest stability expansion ability, achieving a stall margin improvement of 11.28%. [ABSTRACT FROM AUTHOR]

Rice stripe mosaic virus (RSMV) is an emerging pathogen which significantly reduces rice yields in the southern region of China. It is transmitted by the leafhopper Recilia dorsalis, which overwinters in rice fields. Our field investigations revealed that RSMV infection causes delayed rice heading, resulting in a large number of green diseased plants remaining in winter rice fields. This creates a favorable environment for leafhoppers and viruses to overwinter, potentially contributing to the rapid spread and epidemic of the disease. Next, we explored the mechanism by which RSMV manipulates the developmental processes of the rice plant. A rice heading‐related E3 ubiquitin ligase, Heading date Associated Factor 1 (HAF1), was found to be hijacked by the RSMV‐encoded P6. The impairment of HAF1 function affects the ubiquitination and degradation of downstream proteins, HEADING DATE 1 and EARLY FLOWERING3, leading to a delay in rice heading. Our results provide new insights into the development regulation‐based molecular interactions between virus and plant, and highlights the importance of understanding virus‐vector‐plant tripartite interactions for effective disease management strategies. [ABSTRACT FROM AUTHOR]

We study a class of Approximate Message Passing (AMP) algorithms for symmetric and rectangular spiked random matrix models with orthogonally invariant noise. The AMP iterates have fixed dimension |$K \geq 1$|⁠ , a multivariate non-linearity is applied in each AMP iteration, and the algorithm is spectrally initialized with |$K$| super-critical sample eigenvectors. We derive the forms of the Onsager debiasing coefficients and corresponding AMP state evolution, which depend on the free cumulants of the noise spectral distribution. This extends previous results for such models with |$K=1$| and an independent initialization. Applying this approach to Bayesian principal components analysis, we introduce a Bayes-OAMP algorithm that uses as its non-linearity the posterior mean conditional on all preceding AMP iterates. We describe a practical implementation of this algorithm, where all debiasing and state evolution parameters are estimated from the observed data, and we illustrate the accuracy and stability of this approach in simulations. [ABSTRACT FROM AUTHOR]

Multilingualism is becoming increasingly common worldwide, with multilingual studies becoming more popular and accelerating interpersonal language contacts; however, it remains controversial and ambiguous in China. The current study aims to explore code-switching (CS) patterns and factors among Mandarin-dominated mainland Chinese speakers and investigate multilingual development in China through CS, as it is a multilingual practice. Conversational analysis was conducted to analyse daily interactions in short videos posted online, categorise language varieties and frequencies, identify CS patterns, and examine the factors influencing CS patterns. The results revealed that foreign languages and dialects other than Mandarin were spoken by Mandarin-dominated speakers. Three of four CS patterns were also pinpointed regarding language practices in China. Insertion was the most predominant pattern, followed by backflagging and alternation. The CS patterns employed by Mandarin-dominated mainland Chinese speakers were influenced primarily by participant-related factors, followed by linguistic-related factors, sociopsychological factors, convenience, and situational factors. The prevalence of the insertional CS pattern and the influence of personal factors suggest that China's Mandarin-speaking community is in an early phase of multilingual development. [ABSTRACT FROM AUTHOR]

Novel therapeutic strategies against difficult-to-treat bacterial infections are desperately needed, and the faster and cheaper way to get them might be by repurposing existing antibiotics. Nanodelivery systems enhance the efficacy of antibiotics by guiding them to their targets, increasing the local concentration at the site of infection. While recently described nanodelivery systems are promising, they are generally not easy to adapt to different targets, and lack biocompatibility or specificity. Here, nanodelivery systems are created that source their targeting proteins from bacteriophages. Bacteriophage receptor-binding proteins and cell-wall binding domains are conjugated to nanoparticles, for the targeted delivery of rifampicin, imipenem, and ampicillin against bacterial pathogens. They show excellent specificity against their targets, and accumulate at the site of infection to deliver their antibiotic payload. Moreover, the nanodelivery systems suppress pathogen infections more effectively than 16 to 32-fold higher doses of free antibiotics. This study demonstrates that bacteriophage sourced targeting proteins are promising candidates to guide nanodelivery systems. Their specificity, availability, and biocompatibility make them great options to guide the antibiotic nanodelivery systems that are desperately needed to combat difficult-to-treat infections. Zhao et al. demonstrate a strategy that delivers antibiotics to the site of infection using proteins from bacteriophages, which naturally target bacteria. This approach helps the antibiotic regain activity against conventionally resistant strains. [ABSTRACT FROM AUTHOR]

Introduction: Nowadays, the training of implant placement has shifted from once entirely instructor–student teaching to the increasing use of computer‐assisted simulation. Based on computerized virtual planning, dynamic navigation has been used for implant placement with higher accuracy than the traditional freehand protocol. However, whether dynamic navigation benefits to the training of dental students in implant placement remains controversial. This study aimed to compare the surgical performance of dental students in implant placement using computer‐assisted dynamic navigation and freehand approaches. Materials and Methods: A total of 20 dental students (6 males, 14 females, age: 25.6 ± 0.5 years) were enrolled in this study. With the traditional freehand approach (training 1) as the control protocol, computer‐assisted dynamic navigation (training 2) was used in the training of dental students in implant placement. For each training, both the operating time (OT) of students and placement accuracy represented by the linear (at the implant platform, Dpl, and apex, Dap) and angular (Dan) deviations between the virtually planned and placed implants were recorded. Statistical comparisons were made between the two training protocols as well as male and female surgeons. Results: OT2 was around twice of OT1 (p <.0001), whereas Dan1 was almost three times of Dan2 (p <.0001). Dap1 and Dpl1 were significantly higher than Dap2 (p =.014) and Dpl2 (p =.033) respectively. Besides, male students showed statistically higher Dpl1 (p =.033) and Dan1 (p =.002) than females. No significant difference was found between male and female students in OT1, OT2, Dpl2, Dap1, Dap2 and Dan2. Conclusions: Within the limitations of this study, the use of computer‐assisted dynamic navigation in the preclinical training could improve the surgical performance of the dental students in implant placement. The combination of dynamic navigation with the traditional preclinical surgical training may benefit to dental students and could be applied in dental education. [ABSTRACT FROM AUTHOR]

Tetracyclines are currently the most commonly used class of antibiotics, and their residue issue significantly impacts public health safety. In this study, a surface modification of perovskite with cetyltrimethylammonium bromide led to the generation of stable electrochemiluminescence (ECL) emitters in aqueous systems and improved the biocompatibility of perovskite. A perovskite quantum dot‐based ECL sensing strategy was developed. Utilizing the corresponding aptamer of the antibiotics, strain displacement reactions were triggered, disrupting the ECL quenching system composed of perovskite and Ag nanoclusters (Ag NCs) on the electrode surface, generating a signal to achieve quantitative detection of several common tetracycline antibiotics. The perovskite quantum dot provided a strong and stable initial signal, while the efficient catalytic activity of the silver cluster enhanced the recognition sensitivity. Tetracycline, chlortetracycline, and oxytetracycline were used as examples to demonstrate the differentiation and quantitative detection through this method. In addition, the aptasensor exhibited analytical performance with the linear range (0.1–10 μM OTC) and good recovery rates of 94.7% to 101.6% in real samples. This approach has the potential to become a sensitive and practical approach for assessing antibiotic residues. [ABSTRACT FROM AUTHOR]

Insufficient selenization and uneven distribution of elements caused by the poor diffusion and reaction activity of selenium clusters is one of the main issues limiting the efficiency of Cu2ZnSn(S,Se)4 (CZTSSe) solar cells. Here, this work designs a simple and feasible strategy to improve the activity of selenium (Se) by implementing high‐temperature treatment on graphite boxes loaded with Se pellets. The rapid adsorption/desorption characteristics of graphite on active gaseous small‐molecule selenium have successfully introduced hyperactive Se4, Se3, and Se2 into the selenization process. The results indicate that the adsorbed non‐toxic gaseous active Se3 and Se4 can quickly and uniformly diffuse into the precursor film at low temperatures, thereby inducing nucleation and grain growth at both surface and back interface simultaneously, which inhibits the upward migration and aggregation of cations, especially Cu, and promotes the homogenization of elements. The overall relatively Cu‐poor chemical environment suppresses the formation of CuZn defects and [2CuZn+SnZn] defect clusters, and also promotes the generation of favorable VCu. The band tail states and non‐radiative recombination are then optimized. Finally, the CZTSSe solar cells achieve a power conversion efficiency (PCE) of 14.5%, with VOC/VOCSQ of 67% being one of the highest in the literature. [ABSTRACT FROM AUTHOR]

With the high incidence rate, distinctive implant characteristic and unique infection pattern, peri-implantitis (PI) requires a specially designed implant animal model for the researches on the pathogenesis and treatments. Previous small-animal PI models exhibit variability in implant site selection, design, and surgical procedures resulting in unnecessary tissue damage and less effectivity. Herein, a quantitative-analysis-based standardized rat model for transmucosal PI-related research was proposed. After dissecting the anatomic structures of the rat maxilla, we determined that placing the implant anterior to the molars in the rat maxilla streamlined the experimental period and enhanced animal welfare. We standardized the model by controlling the rat strain, gender, and size. The customized implant and a series of matched surgical instruments were appropriately designed. A clear, step-by-step surgical process was established. These designs ensured the success rate, stability, and replicability of the model. Each validation method confirmed the successful construction of the model. This study proposed a quantitative-analysis-based standardized transmucosal PI rat model with improved animal welfare and reliable procedures. This model could provide efficient in vivo insights to study the pathogenesis and treatments of PI and preliminary screening data for further large-animal and clinical trials., Competing Interests: Competing interests: The authors declare that they have no competing interests., (Copyright © 2024 Xingchen Liu et al.)

Objective: To observe the effect and mechanism of electroacupuncture (EA) on non-canonical pathway of hepatocellular pyroptosis in nonalcoholic fatty liver disease (NAFLD)., Methods: Sixty male SD rats were randomly divided into a normal diet group ( n =15) and a high fat modeling group ( n =45). The rats in the high fat modeling group were fed with customized high fat diet for 8 weeks to establish NAFLD model. Thirty successfully modeled rats were selected and randomly divided into a model group ( n =10), an EA group ( n =10) and a non-acupoint with shallow needling group ( n =10), and 10 rats were randomly selected from the normal diet group as the control group additionally. In the EA group, EA was applied at bilateral "Fenglong" (ST 40) and "Ganshu" (BL 18), with disperse-dense wave, in frequency of 4 Hz/20 Hz and in intensity of 3 mA. In the non-acupoint with shallow needling group, shallow needling was delivered at points 5 mm from bilateral "Fenglong" (ST 40) and "Ganshu" (BL 18), the EA stimulation parameters were same as the EA group. The intervention was given once a day, 20 min a time, 5 days a week for 4 weeks in the two groups. After intervention, the liver morphology was observed by oil red "O" staining, the serum levels of lipopolysaccharide (LPS), interleukin (IL)-1β, IL-18 and tumor necrosis factor-α (TNF-α) were detected by ELISA, the protein expression of gasdermin D (GSDMD), GSDMD-N, cysteine aspartic acid specific protease-11 (Caspase-11), IL-1β, IL-18 and TNF-α in liver tissue were detected by Western blot, the mRNA expression of GSDMD, Caspase-11, IL-1β, IL-18 and TNF-α in liver tissue was detected by real-time PCR in rats of each group., Results: In the model group, vacuoles in different size were found in the hepatocellular cytoplasm, and the fat droplets were in schistose accumulation. Compared with the model group, the hepatocellular fat droplets and the degree of hepatic steatosis were reduced in the EA group and the non-acupoint with shallow needling group. Compared with the control group, the serum levels of LPS, IL-1β, IL-18 and TNF-α were increased ( P <0.01), the protein and mRNA expression of GSDMD, Caspase-11, IL-1β, IL-18, TNF-α as well as the protein expression of GSDMD-N in the liver tissue were increased ( P <0.01) in the model group. Compared with the model group, the serum levels of LPS, IL-1β, IL-18 and TNF-α were decreased ( P <0.01), the protein and mRNA expression of GSDMD, IL-1β, IL-18 and TNF-α in the liver tissue were decreased ( P <0.01), the protein expression of GSDMD-N and the mRNA expression of Caspase-11 in the liver tissue were decreased ( P <0.01) in the EA group and the non-acupoint with shallow needling group. Compared with the model group, the protein expression of Caspase-11 in the liver tissue was decreased ( P <0.01) in the EA group. Compared with the non-acupoint with shallow needling group, the serum levels of LPS, IL-1β, IL-18 and TNF-α were decreased ( P <0.01), the protein and mRNA expression of GSDMD, Caspase-11, IL-1β and IL-18 in the liver tissue were decreased ( P <0.01), the protein expression of GSDMD-N and the mRNA expression of TNF-α in the liver tissue were decreased ( P <0.01) in the EA group., Conclusion: EA can inhibit hepatocellular pyroptosis in NAFLD rats, and its mechanism may be related to reducing the serum level of LPS, and down-regulating the expression of the non-canonical pathway related factors i.e. GSDMD, GSDMD-N, Caspase-11, IL-1β, IL-18 and TNF-α.

Tetracyclines are currently the most commonly used class of antibiotics, and their residue issue significantly impacts public health safety. In this study, a surface modification of perovskite with cetyltrimethylammonium bromide led to the generation of stable electrochemiluminescence (ECL) emitters in aqueous systems and improved the biocompatibility of perovskite. A perovskite quantum dot-based ECL sensing strategy was developed. Utilizing the corresponding aptamer of the antibiotics, strain displacement reactions were triggered, disrupting the ECL quenching system composed of perovskite and Ag nanoclusters (Ag NCs) on the electrode surface, generating a signal to achieve quantitative detection of several common tetracycline antibiotics. The perovskite quantum dot provided a strong and stable initial signal, while the efficient catalytic activity of the silver cluster enhanced the recognition sensitivity. Tetracycline, chlortetracycline, and oxytetracycline were used as examples to demonstrate the differentiation and quantitative detection through this method. In addition, the aptasensor exhibited analytical performance with the linear range (0.1-10 μM OTC) and good recovery rates of 94.7% to 101.6% in real samples. This approach has the potential to become a sensitive and practical approach for assessing antibiotic residues., (© 2024 John Wiley & Sons Ltd.)