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The thickness of a cover significantly influences both the bonding performance and the durability of materials against frost resistance. This research investigates the degradation and damage distribution of fundamental mechanical properties in two specimens of recycled aggregate concrete (RAC), each with varying sizes, following freeze-thaw cycles (FTCs). This comparison is facilitated through non-destructive and damage tests. Subsequently, the influence of freeze-thaw damage (FTD) on the bond strength of specimens with differing cover thicknesses is examined via pull-out tests on 14 groups of center pull-out specimens. Lastly, the bond strength is theoretically analyzed. The test results reveal that FTCs diminish the material strength of RAC, and the FTD distribution within RAC specimens is not uniform. The surface concrete sustains a higher degree of damage compared to the internal concrete, resulting in an average FTD of small-size specimens that surpasses that of large-size specimens. The residual strength of RAC can be assessed using a non-destructive test, specifically the ultrasonic wave velocity test. For center pull-out specimens, FTD not only decreases the material strength but also increases the wedge splitting angle while reducing the critical protective layer thickness. This paper proposes a soft sleeve correction theory that comprehensively accounts for the effects of FTD. When combined with non-destructive test results—namely those from the ultrasonic wave velocity test—this theory can effectively evaluate the bond strength of RAC post-FTD. This approach offers valuable insights for the design and assessment of recycled concrete in cold climates.

Abstract Tislelizumab, an anti‐programmed cell death protein 1 monoclonal antibody, has demonstrated improved survival benefits over standard of care for multiple cancer indications. We present the clinical rationale and data supporting tislelizumab dose recommendation in patients with advanced tumors. The phase I, first‐in‐human, dose‐finding BGB‐A317‐001 study (data cutoff [DCO]: August 2017) examined the following tislelizumab dosing regimens: 0.5–10 mg/kg every 2 weeks (q2w), 2–5 mg/kg q2w or q3w, and 200 mg q3w. Similar objective response rates (ORRs) were reported in the 2 and 5 mg/kg q2w or q3w cohorts. Safety outcomes (grade ≥3 adverse events [AEs], AEs leading to dose modification/discontinuation, immune‐mediated AEs, and infusion‐related reactions) were generally comparable across the dosing range examined. These results, alongside the convenience of a fixed q3w dose, formed the basis of choosing 200 mg q3w as the recommended dosing regimen for further clinical use. Pooled exposure–response (E–R) analyses by logistic regression using data from study BGB‐A317‐001 (DCO: August 2020) and three additional phase I/II studies (DCOs: 2018–2020) showed no statistically significant correlation between tislelizumab pharmacokinetic exposure and ORR across multiple solid tumor types or classical Hodgkin's lymphoma, nor was exposure associated with any of the safety end points evaluated over the dose range tested. Hence, tislelizumab showed a relatively flat E–R relationship. Overall, the totality of data, including efficacy, safety, and E–R analyses, together with the relative convenience of a fixed q3w dose, provided clinical rationale for the recommended dosing regimen of tislelizumab 200 mg q3w for multiple cancer indications.

The J-TEXT capability is enhanced compared to two years ago with several upgrades of its diagnostics and the increase of electron cyclotron resonance heating (ECRH) power to 1 MW. With the application of electron cyclotron wave (ECW), the ECW assisted plasma startup is achieved; the tearing mode is suppressed; the toroidal injection of 300 kW ECW drives around 24 kA current; fast electrons are generated with toroidal injected ECW and the runaway current conversion efficiency increases with ECRH power. The mode coupling between 2/1 and 3/1 modes are extensively studied. The coupled 2/1 and 3/1 modes usually lead to major disruption. Their coupling can be either suppressed or avoided by external resonant magnetic perturbation fields and hence avoids the major disruption. It is also found that the 2/1 threshold of external field is significantly reduced by a pre-excited 3/1 mode, which can be either a locked island or an external kink mode. The disruption control is studied by developing prediction methods capable of cross tokamak application and by new mitigation methods, such as the biased electrode or electromagnetic pellet injector. The high-density operation and related disruptions are studied from various aspects. Approaching the density limit, the collapse of the edge shear layer is observed and such collapse can be prevented by applying edge biasing, leading to an increased density limit. The density limit is also observed to increase, if the plasma is operated in the poloidal divertor configuration or the plasma purity is increased by increasing the pre-filled gas pressure or ECRH power during the start-up phase.

According to current regulations, welding is strictly prohibited for prestressed and tension cables. In response, this article proposes the use of a portable spot-welding machine to spot weld steel strands. This method generates a small current during spot welding, with a voltage of only 3 V to 5 V, and does not damage the internal structure of the steel strand. To effectively monitor cable tension in cable-supported structures, a novel approach utilizing a chip-based, encapsulated spot-welded strain sensor was investigated. The strain sensing capability, temperature sensitivity, stress relaxation, and static load responses were investigated on the proposed smart steel strand cables with spot-welded strain sensors. The theoretical analyses and finite element simulations revealed that the strain transfer efficiency of the spot-welded strain sensor exceeded 96%. The experimental results demonstrated that the load-strain relationship of the smart steel strand cable had a fitting degree greater than 0.999, and the tension errors obtained under different loads were within 1.26%. The tension full capacity errors measured at different temperatures were generally within 1.0%. The relaxation rate of the smart steel strand cable after 120 h was 3.78% and reduced the sensor accuracy error by 3.97%. Thus, the proposed strain sensor equipped with a smart steel strand cable is suitable for use in long-term tension monitoring.

Most cable arch bridge damage accidents are caused by bridge collapse due to fracture of the short sling of the arch bridge. The service life of the short sling is much lower than the design life, mainly resulting from the action of vehicles and temperature, and the arch rib and the bridge floor will have relative displacement along the bridge direction, which leads to the emergence of bending stress due to the different axes at both ends of the short sling, forming local stress concentration. The stress concentration is coupled with corrosion to accelerate the damage to the sling. To study the influence of shaft deflection on the mechanical properties of short slings of steel strands in arch bridges, this study analyzes the distribution law of the shaft deflection angle of arch bridge slings under the action of vehicle and temperature loads for a medium-bearing arch bridge with a main span of 560 m. The results show that under different vehicle and temperature loads, the axial deflection angle of the short sling is the largest, and the closer it is to the center of the span, the smaller the axial deflection angle. The static and fatigue properties of 1, 3, 7, 9, 12, 19, and 27 strands of whole bunch extruded strand slings were simulated and analyzed under a 0.45σb force when the axial deflection angle of the strand slings was 0 mrad, 10 mrad, 20 mrad, and 30 mrad. The results show that the ultimate tensile properties, breaking strength, and fatigue life of the strand slings decreased to a certain extent with increasing shaft deflection angle. The accuracy of the finite element models is verified by the ultimate tensile test and the fatigue test. This study explores the bending deflection results of the short slings of arch bridges due to the different axes of the upper and lower anchorages and provides the necessary theoretical support for the design and fatigue life estimation of the short slings of arch bridges.